Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 27, 2024

Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.

Язык: Английский

PIM1 enhances insulin secretion and inhibits ferroptosis of high glucose-induced pancreatic β-cells through strengthening PINK1/Parkin-mediated mitophagy via inactivating JNK/p38 signaling pathway

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102722 - 102722

Опубликована: Янв. 7, 2025

Язык: Английский

Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis

Redox Biology, Год журнала: 2025, Номер unknown, С. 103619 - 103619

Опубликована: Март 1, 2025

Язык: Английский