Skin Healing Potential of Bioactive Components From Lycoperdon lividum Mushroom Versus β‐Sitosterol in Rat Model of Burn Wounds

Microscopy Research and Technique, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

ABSTRACT Burn injury elicits an inflammatory response, metabolic abnormalities, and distributional shock leading to diverse organ dysfunctions with remarkable morbidity mortality. Sluggish wound healing, infections, hypertrophic scars still struggle in burn treatment. Lycoperdon lividum , a puffball mushroom enriched polyphenols, has outstanding antioxidative anti‐inflammatory properties. This study aimed assess the benefits of L. on second‐degree lesions rat model at 100°C. Seventy‐five male rats were haphazardly separated into five groups 15 each: Control (without any skin induction/treatment), (skin induction/non‐treated), β‐sitosterol (treated topical 0.25%), Vehicle Vaseline), watery extract 10%). Rats euthanized Days 5, 10, 20 experiment. was analyzed using HPLC techniques. Skin samples collected for microscopical histopathological examinations. Biomarkers involving IL‐6, IL‐10, TGF‐β1, TNF‐α, VEGF homogenates. The chromatogram revealed distinct peaks bioactive compounds including kaempferol, rutin, ferulic acid, caffeic chlorogenic quercetin, gallic acid. greatly alleviated via improving contraction, correcting inflammation, granulation aberrations while boosting fibrosis. outcomes validated by analyses. Further, markedly improved healing wounds regulating cytokines (IL‐6 TNF‐α), (IL‐10 TGF‐β1), angiogenic (VEGF) tissues. potential thanks its antioxidant actions.

Язык: Английский

A Case Study on Complete Pathological Response in Advanced Rectal Cancer Patient with Oxaliplatin-based Chemotherapy without Cumulative Neurotoxicity

Journal of Gastrointestinal Cancer, Год журнала: 2025, Номер 56(1)

Опубликована: Апрель 16, 2025

Язык: Английский

Vildagliptin topical ointment: an effective treatment for imiquimod-induced psoriasis in mice

Journal of Molecular Histology, Год журнала: 2025, Номер 56(3)

Опубликована: Апрель 26, 2025

Язык: Английский