Inverse U-shaped association between weight-adjusted waist index and femur bone mineral density in the older adults:NHANES 2005-2018 DOI Creative Commons
Jun Wang, Xin Lv, Jianjun Huang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract The weight-adjusted waist Index (WWI) emerges as a novel metric for assessing obesity. aim of this research was to explore the association between WWI and total femoral Bone Mineral Density (BMD) in older adults United States. This study involving individuals aged 60 years utilized data from National Health Nutrition Examination Survey (NHANES) across five survey cycles (from 2005–2010, 2013–2014, 2017–2018) examine femur BMD. In research, we employed suite statistical methods both linear nonlinear associations. Additionally, threshold effect analysis conducted ascertain saturation WWI. Analysis via multivariate regression uncovered notably positive correlation BMD among 7292 US seniors [β: 0.0138, 95% CI: (0.0069, 0.0206), P: 0.0003]. Consistent correlations were observed various demographic subgroups. Furthermore, smooth curve fitting ,an inverse U-shaped identified BMD.And analysis, critical inflection point established at 11.93 cm/√kg. So, an adults,and maintaining certain level may have protective on

Язык: Английский

Impact of Central Obesity on Bone Mineral Density Across Life Stages: A Genetic Epidemiology and Cross-Sectional Study DOI Creative Commons

Camilo Alberto Pinzon Galvis,

yuhong jiang,

Xianhao Huang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Abstract Introduction: This study aimed to investigate the association and causality between central obesity bone mineral density (BMD). Methods We utilized linkage disequilibrium score regression (LDSC) Mendelian randomization (MR) assess genetic correlations causal relationships waist circumference adjusted for BMI (WCadjBMI) total body less head BMD (TB-BMD). Additionally, a cross-sectional analysis of 7,452 participants evaluated relationship A shape index (ABSI) TB-BMD using weighted multivariable linear smooth curve fitting. Results LDSC MR confirmed negative WCadjBMI (β=-0.16; 95% CI: -0.26, -0.07). The indicated that an increase 0.01 ABSI corresponded decrease 0.035 (g/cm2), with this effect being particularly pronounced in males older adults. An inflection point was identified at = 0.076: below threshold, positively correlated pelvis BMD, whereas above it, became negative. Conclusions Central is significantly negatively related BMD. Maintaining within 0.058–0.078 crucial individuals mass accrual (20–30 years) stabilization (30–45 periods. In contrast, managing people experiencing early loss (45–60 presents greater complexity warrants further investigation.

Язык: Английский

Процитировано

0
Commentary: Negative association between Body Roundness Index and bone mineral density: insights from NHANES DOI Creative Commons
Chenglong Wang, Xuelei Zhang

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 28, 2025

We read with great interest the article by Ding et al. (1) entitled "Negative association between Body Roundness Index and bone mineral density: insights from NHANES." In this study, authors explored relationship body roundness index (BRI) total density (BMD) in U.S. adults. BRI, a newer anthropometric measure, has been shown to more comprehensively reflect visceral fat distribution compared other traditional indices. With weight is not part of equation, waist circumference measured along height plugged into formula estimate adipose tissue. The constructed three weighted multivariate regression models explore BRI BMD: Model 1 was unadjusted, 2 adjusted for key demographic variables, 3 all covariates. findings demonstrate notable inverse BMD, thus concluded that higher associated lower BMD potentially greater risk developing osteoporosis, advocating use as valuable marker early intervention. commend their rigorous study design analytical efforts; however, we would like raise several concerns offer suggestions further consideration help improve investigations. adverse effects inflammation on bones. detailed discussion 57 potential mechanisms through which accumulation promotes osteoporosis. 58The suggest using clinically assessing osteoporosis 60 achieving However, diagnostic ability evaluated 61 study. encourage perform receiver operating characteristic curve analysis compare 62 predictive obesity assessment indicators (not limited BMI) 63 novel measures, such Weight-adjusted Waist (6), A Shape (7), 64Abdominal Volume (8), Visceral Adiposity (9), Lipid Accumulation Product 65 (10). Beyond analysis, incorporating additional metrics 66 net reclassification establish whether provides incremental value 67 over thereby highlighting significance 68Discussion 69This an innovative exploration adults; 70 believe should be interpreted caution. Specifically, emphasize 71 when investigating measures it 72 crucial consider collinearity BMI. addition, longitudinal studies examine 73 impact loss or redistribution across tertiles provide 74 causal relationships. hope our will assist readers interpreting 75 effectively perspectives future research. 76

Язык: Английский

Процитировано

0
Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005–2018 DOI Creative Commons

Z. Wang,

Guo-Liang Ma,

Bo Xu

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 7, 2025

Despite accumulating evidence on central obesity and osteoporosis, the role of a body shape index (ABSI), nonlinear quantifying via mass (BMI), waist circumference (WC), height, remains controversial underexplored. Although recent meta-analyses suggest may modulate fracture risk bidirectionally, no research has comprehensively compared ABSI with traditional adiposity metrics, such as BMI, WC, waist-to-height ratio (WHtR), to predict site-specific changes in bone mineral density (BMD) across anatomical regions. This study utilized National Health Nutrition Examination Survey (NHANES) data from 2005 2018, involving 12,421 participants. was computed using formula: = WC/(BMI²/³ × Height¹/²). BMD assessed at four sites-the total femur (TF), femoral neck (FN), trochanter (TR), intertrochanter (IN) regions-via dual-energy X-ray absorptiometry (DXA). The association between analyzed multiple regression models generalized additive model (GAM). To compare ABSI's predictive efficacy conventional indices, analyses juxtaposed against WHtR assessing correlations BMD. After full covariate adjustment, significant negative observed regions (P< 0.01). Smoothed curve fitting revealed relationship threshold effect among middle-aged older individuals. Additionally, an inverted J-shaped all Meanwhile, showed associations sites (β -0.27 -0.31, p-trend< 0.000001), whereas exhibited positive (WHtR showing strongest effect: β 0.41-0.69). highlights ability detect adiposity-related loss obscured by metrics. robust inverse -0.31), persisting analyses, establish it novel biomarker skeletal fragility. Unlike indices reflecting mechanical loading benefits (BMI 0.008-0.012; WC 0.003-0.005; 0.41-0.69), specifically captures visceral fat-driven metabolic disorder-a critical pathway for osteoporosis stratification normal-weight obese populations.

Язык: Английский

Процитировано

0
The Role of Sex Steroid Hormones in the Association Between Manganese Exposure and Bone Mineral Density: National Health and Nutrition Examination Survey 2013–2018 DOI Creative Commons
Xiang Zhao,

Jiayi Li,

Jincong Yu

и другие.

Toxics, Год журнала: 2025, Номер 13(4), С. 296 - 296

Опубликована: Апрель 11, 2025

This study investigates the association between blood Mn and bone mineral density (BMD), focusing on mediating role of sex steroids, using data from 8617 participants in National Health Nutrition Examination Survey (NHANES) 2013–2018. Weighted multiple linear regression models were used to examine total BMD, mediation analyses explored roles testosterone (TT), estradiol (E2), hormone-binding globulin (SHBG) Mn-BMD relationship, stratified by menopausal status. Blood was negatively associated with BMD both sexes, a pronounced effect postmenopausal women. SHBG mediated 37.16% men, whereas no effects found E2 exhibited significant indirect effect, suggesting that reduced levels may amplify Mn’s BMD. These findings indicate exposure is decreased potentially through alterations highlighting importance considering hormone status when evaluating impact

Язык: Английский

Процитировано

0
Abdominal Obesity: A Lethal Factor in Elderly Male Osteoporosis Patients—Insights from NHANES DOI

Ziyao Ding,

Xiaoli Qu,

Qingbing Zhu

и другие.

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2024, Номер unknown, С. 103788 - 103788

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Inverse U-shaped association between weight-adjusted waist index and femur bone mineral density in the older adults:NHANES 2005-2018 DOI Creative Commons
Jun Wang, Xin Lv, Jianjun Huang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract The weight-adjusted waist Index (WWI) emerges as a novel metric for assessing obesity. aim of this research was to explore the association between WWI and total femoral Bone Mineral Density (BMD) in older adults United States. This study involving individuals aged 60 years utilized data from National Health Nutrition Examination Survey (NHANES) across five survey cycles (from 2005–2010, 2013–2014, 2017–2018) examine femur BMD. In research, we employed suite statistical methods both linear nonlinear associations. Additionally, threshold effect analysis conducted ascertain saturation WWI. Analysis via multivariate regression uncovered notably positive correlation BMD among 7292 US seniors [β: 0.0138, 95% CI: (0.0069, 0.0206), P: 0.0003]. Consistent correlations were observed various demographic subgroups. Furthermore, smooth curve fitting ,an inverse U-shaped identified BMD.And analysis, critical inflection point established at 11.93 cm/√kg. So, an adults,and maintaining certain level may have protective on

Язык: Английский

Процитировано

0