Investigation of antituberculosis, antimicrobial, anti-inflammatory efficacies of newly synthesized transition metal(II) complexes of hydrazone ligands: structural elucidation and theoretical studies

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 23, 2023

Tuberculosis disease is a serious threat to humans and spreading quickly worldwide, therefore, find potent drug, the synthesis of hydrazone ligands endowed Co(II), Ni(II), Cu(II), Zn(II) metal complexes were carried out well characterized by numerous spectral analytical techniques. The octahedral geometry was confirmed analysis. Further, in vitro antituberculosis efficacy compounds (1-10) revealed that (6), (9), (10) have highest potency control TB malformation with 0.0028 ± 0.0013-0.0063 0.0013 µmol/mL MIC value while complex (0.0028 µmol/mL) has nearly four time suppress comparison streptomycin (0.0107 0.0011 µmol/mL). antimicrobial anti-inflammatory evaluations more active lowest (0.0057-0.0114 IC50 (7.14 0.05 µM) values, correspondingly which are comparable their respective standard drugs. Furthermore, theoretical studies such as molecular docking, DFT, MESP ADMET employed authenticate HL2 ligand (2) its (7-10) zinc(II) might be utilized novel drug candidate for tuberculosis dysfunctions. So, present research gives new insight vivo investigation compounds.

Язык: Английский

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Fe(III), Ni(II), and Cu(II)-moxifloxacin-tri-substituted imidazole mixed ligand complexes: Synthesis, structural, DFT, biological, and protein-binding analysis

Inorganic Chemistry Communications, Год журнала: 2023, Номер 158, С. 111486 - 111486

Опубликована: Сен. 24, 2023

Язык: Английский

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A review on ‘sulfonamides’: their chemistry and pharmacological potentials for designing therapeutic drugs in medical science

Journal of Coordination Chemistry, Год журнала: 2023, Номер 76(5-6), С. 546 - 580

Опубликована: Март 19, 2023

The discovery of new chemical entities having enhanced bioactivities and improved functionalities to overcome the prevailing antibiotic resistance emerging diseases has evolved as one most needed research areas in pharmaceutical field. Intensive been done on metal-based drugs a result, metal complexes various Schiff bases are acknowledged potential area bioinorganic chemistry account their promising applicable uses several fields science. base sulfonamides versatile pharmacophores forming stable compounds by coordinating with metals oxidation states. As therapeutic candidates, they have actively used many applications including antifungal, analgesic, anti-inflammatory, antiviral, antitumor, antibacterial more. There worldwide risk drug medical field pathogenic microbes capable deactivating substances. This review summarizes developments that taken place from 2008 2022 activities derived compounds.

Язык: Английский

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A review on the antimicrobial assessment of triazole-azomethine functionalized frameworks incorporating transition metals

Journal of Molecular Structure, Год журнала: 2023, Номер 1288, С. 135744 - 135744

Опубликована: Май 9, 2023

Язык: Английский

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Development of tripodal imine metal chelates: Synthesis, physicochemical inspection, theoretical studies and biomedical evaluation

Inorganic Chemistry Communications, Год журнала: 2024, Номер 162, С. 112248 - 112248

Опубликована: Фев. 28, 2024

Язык: Английский

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Applications of metal complexes in analytical chemistry: A review article

Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215568 - 215568

Опубликована: Ноя. 24, 2023

Язык: Английский

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Design, structural inspection of some new metal chelates based on benzothiazol- pyrimidin-2-ylidene ligand: Biomedical studies and molecular docking approach

Inorganic Chemistry Communications, Год журнала: 2023, Номер 158, С. 111587 - 111587

Опубликована: Окт. 14, 2023

Язык: Английский

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A promising acetylcholinesterase and butyrylcholinesterase inhibitors: In vitro enzymatic and in silico molecular docking studies of benzothiazole-based oxadiazole containing imidazopyridine hybrid derivatives

Results in Chemistry, Год журнала: 2024, Номер 7, С. 101503 - 101503

Опубликована: Янв. 1, 2024

Alzheimer's dementia (AD), the most prevalent neurodegenerative disorder adversely affecting elderly citizens worldwide, is an incurable with no effective medication found till date. Taking into account seriousness of this issue, imidazopyridine-based benzothiazole-oxadiazole hybrid derivatives were synthesized as anti-Alzheimer's agents. The efficacy these scaffolds was compared standard Donepezil (IC50 = 14.47 ± 1.20 μM for AChE and 19.90 2.40 BuChE). All novel exhibited biological activity covering a range IC50 6.70 1.65 41.65 7.20 6.40 1.80 44.65 7.40 BuChE. Analog 6p having BuChE lead candidate series maximum inhibition due to presence small sized highly electronegative fluoro moieties, inhibiting enzymes through hydrogen bonds. These interactions also studied in molecular docking investigations compounds. Furthermore, ADME analysis conducted study assisted drug likeness potent analogs. Synthetic structural confirmation achieved 13C NMR, 1H NMR HREI-MS.

Язык: Английский

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Synthesis and characterization of indazole derived Schiff base ligands and their metal complexes: Biological and computational studies

Inorganic Chemistry Communications, Год журнала: 2024, Номер 166, С. 112585 - 112585

Опубликована: Май 25, 2024

Язык: Английский

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Hydrazone-containing organotin(IV) complexes: synthesis, characterization, antimicrobial, antioxidant activity and molecular-docking studies

BioMetals, Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Язык: Английский

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