Cosmetics,
Год журнала:
2024,
Номер
11(5), С. 162 - 162
Опубликована: Сен. 19, 2024
The
present
study
aimed
to
analyze
the
antifungal,
antioxidant,
and
irritant
potential
of
citronella
oil,
both
isolated
combined
with
caffeic
acid
phenethyl
ester
(CAPE),
for
topical
oral
candidiasis.
antioxidant
was
evaluated
using
two
methods,
DPPH
test
reducing
power
(FRAP),
while
solutions
assessed
through
hen’s
egg
chorioallantoic
membrane
(HET-CAM).
(IC50)
values
CITRO
III
+
CAPE
combination
were
32
±
9
mg/mL,
CAPE,
13
3
mg/mL.
results
from
FRAP
method
revealed
a
low
iron-reducing
1.25
mg/mL
0.0775
(CITRO
III),
showing
no
significant
difference
compared
solution
0.15
CAPE.
antibacterial
activity
in
vitro
against
microorganisms
methods:
microdilution
biofilm
assay.
showed
that
MIC
MFC
0.5
at
tested
times
(24
h
48
h).
For
0.031
assay,
compounds
combinations
1
min
6
significantly
different
controls
(p
<
0.05).
Furthermore,
HET-CAM
demonstrated
absence
irritability.
Based
on
these
premises,
antifungal
actions,
irritability
proven.
Moreover,
this
work
presents
natural
interest
pharmaceutical
industry.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 23, 2023
Tuberculosis
disease
is
a
serious
threat
to
humans
and
spreading
quickly
worldwide,
therefore,
find
potent
drug,
the
synthesis
of
hydrazone
ligands
endowed
Co(II),
Ni(II),
Cu(II),
Zn(II)
metal
complexes
were
carried
out
well
characterized
by
numerous
spectral
analytical
techniques.
The
octahedral
geometry
was
confirmed
analysis.
Further,
in
vitro
antituberculosis
efficacy
compounds
(1-10)
revealed
that
(6),
(9),
(10)
have
highest
potency
control
TB
malformation
with
0.0028
±
0.0013-0.0063
0.0013
µmol/mL
MIC
value
while
complex
(0.0028
µmol/mL)
has
nearly
four
time
suppress
comparison
streptomycin
(0.0107
0.0011
µmol/mL).
antimicrobial
anti-inflammatory
evaluations
more
active
lowest
(0.0057-0.0114
IC50
(7.14
0.05
µM)
values,
correspondingly
which
are
comparable
their
respective
standard
drugs.
Furthermore,
theoretical
studies
such
as
molecular
docking,
DFT,
MESP
ADMET
employed
authenticate
HL2
ligand
(2)
its
(7-10)
zinc(II)
might
be
utilized
novel
drug
candidate
for
tuberculosis
dysfunctions.
So,
present
research
gives
new
insight
vivo
investigation
compounds.
Journal of Coordination Chemistry,
Год журнала:
2023,
Номер
76(5-6), С. 546 - 580
Опубликована: Март 19, 2023
The
discovery
of
new
chemical
entities
having
enhanced
bioactivities
and
improved
functionalities
to
overcome
the
prevailing
antibiotic
resistance
emerging
diseases
has
evolved
as
one
most
needed
research
areas
in
pharmaceutical
field.
Intensive
been
done
on
metal-based
drugs
a
result,
metal
complexes
various
Schiff
bases
are
acknowledged
potential
area
bioinorganic
chemistry
account
their
promising
applicable
uses
several
fields
science.
base
sulfonamides
versatile
pharmacophores
forming
stable
compounds
by
coordinating
with
metals
oxidation
states.
As
therapeutic
candidates,
they
have
actively
used
many
applications
including
antifungal,
analgesic,
anti-inflammatory,
antiviral,
antitumor,
antibacterial
more.
There
worldwide
risk
drug
medical
field
pathogenic
microbes
capable
deactivating
substances.
This
review
summarizes
developments
that
taken
place
from
2008
2022
activities
derived
compounds.
Results in Chemistry,
Год журнала:
2024,
Номер
7, С. 101503 - 101503
Опубликована: Янв. 1, 2024
Alzheimer's
dementia
(AD),
the
most
prevalent
neurodegenerative
disorder
adversely
affecting
elderly
citizens
worldwide,
is
an
incurable
with
no
effective
medication
found
till
date.
Taking
into
account
seriousness
of
this
issue,
imidazopyridine-based
benzothiazole-oxadiazole
hybrid
derivatives
were
synthesized
as
anti-Alzheimer's
agents.
The
efficacy
these
scaffolds
was
compared
standard
Donepezil
(IC50
=
14.47
±
1.20
μM
for
AChE
and
19.90
2.40
BuChE).
All
novel
exhibited
biological
activity
covering
a
range
IC50
6.70
1.65
41.65
7.20
6.40
1.80
44.65
7.40
BuChE.
Analog
6p
having
BuChE
lead
candidate
series
maximum
inhibition
due
to
presence
small
sized
highly
electronegative
fluoro
moieties,
inhibiting
enzymes
through
hydrogen
bonds.
These
interactions
also
studied
in
molecular
docking
investigations
compounds.
Furthermore,
ADME
analysis
conducted
study
assisted
drug
likeness
potent
analogs.
Synthetic
structural
confirmation
achieved
13C
NMR,
1H
NMR
HREI-MS.
