Old and New Biomarkers in Idiopathic Recurrent Acute Pericarditis (IRAP): Prognosis and Outcomes

Current Cardiology Reports, Год журнала: 2025, Номер 27(1)

Опубликована: Янв. 11, 2025

Abstract Purpose of Review To outline the latest discoveries regarding utility and reliability serum biomarkers in idiopathic recurrent acute pericarditis (IRAP), considering recent findings on its pathogenesis. The study highlights predictive role these potential short- (cardiac tamponade, recurrences) long-term complications (constrictive pericarditis, death). Recent Findings pathogenesis has been better defined years, focusing autoinflammatory pathway. New studies have demonstrated pivotal classical inflammatory distinguishing phenotypes (high-grade vs. low-grade inflammation) defining outcomes this condition. Summary Pericarditis involves intense activity, which causes elevation different markers, such as C-reactive protein, erythrocyte sedimentation rate, neutrophils platelets, amyloid A D-Dimer. Conversely, lymphocytes are often reduced, well hemoglobin during phase. Cardiac troponins T I elevated up to 30% cases. Biomarker for CRP-negative cases is needed. Other markers proposed diagnosis prognosis IRAP, anti-heart antibodies anti-intercalated disk antibodies, but we need further validate them.

Язык: Английский

Exploring the potential of D-dimer as a diagnostic and prognostic biomarker for acute pericarditis

Biomarkers in Medicine, Год журнала: 2024, Номер unknown, С. 1 - 3

Опубликована: Дек. 28, 2024

Язык: Английский