Development of a novel risk signature revealing prognostic and tumor microenvironmental features in breast cancer

Medicine, Год журнала: 2025, Номер 104(5), С. e41369 - e41369

Опубликована: Янв. 31, 2025

This study aimed to devise a breast cancer (BC) risk signature for based on pyrimidine metabolism-related genes (PMRGs) evaluate its prognostic value and association with drug sensitivity. Transcriptomic clinical data were retrieved from The Cancer Genome Atlas database Gene Expression Omnibus repository. Pyrimidine metabolism-associated identified the Molecular Signatures Database collection. A was constructed through Cox regression Lasso methods. Further, relationship between PMRG-derived feature clinicopathological characteristics, gene expression patterns, somatic mutations, susceptibility, tumor immune microenvironment thoroughly investigated, culminating in development of nomogram. PMRGs displayed differential diverse mutations BC. Univariate analysis 36 significantly associated BC prognosis, leading categorization 2 molecular subtypes discernible differences prognosis. Using regression, composed 16 established, wherein high-risk scores indicative poor also related chemotherapy regimens showed significant correlations sensitivity multiple drugs. Furthermore, distinct properties, profiles, mutation patterns evident across varying scores. Ultimately, nomogram incorporating PMRGs-based alongside stage, status, demonstrating excellent performance prognosis prediction. We successfully developed PMRG-based that effectively combines attributes accurate assessment

Язык: Английский

Healthcare provider perspectives on a clinical decision tool to support individualized exercise prescriptions and discussions for breast cancer survivors

Journal of Cancer Survivorship, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract Purpose We evaluated healthcare providers’ current knowledge, practices, and perspectives on a novel clinical decision tool (beta-version) to facilitate individualized exercise prescriptions discussions in settings. Methods recruited providers who had treated or provided care breast cancer survivors aged ≥ 35-years the past 12 months. The participants were presented with provide recommendations considering women’s individual, clinical, contextual characteristics. Validated reliable pre-existing instruments used survey practices regarding discussions, beta-version (paper-draft) of tool. Results sample consisted complete responses from 177 including oncologists (27.7%), primary physicians (10.7%), specialists (19.8%), occupational/physical therapists (18.1%), advanced providers, nurses, navigators, social workers (23.7%). Median years experience was 8-years (range: 5–13). Overall, 62.1% ( n = 110) reported that they knowledgeable about counseling based guidelines. Among 68), only 39.7% identifying patients for referals. majority agreed would find offering information useful 148, 83.6%), use it regularly inform practice (82.5%). ‘Exercise Readiness’, Resources at Home’, ‘Quality-of-Life’ highest rated items inclusion prescriptions. Provider incorporated into Conclusion A characteristics may support Implications An evidence-based increase provider confidence discuss, educate, encourage, referrals survivors.

Язык: Английский

Exploring Success Factors for Digital Patient Decision Aid Implementation: A Hybrid Fuzzy Delphi and DEMATEL Approach

Опубликована: Май 24, 2024

Язык: Английский