Plant Stress,
Год журнала:
2024,
Номер
12, С. 100435 - 100435
Опубликована: Март 15, 2024
Climatic
changes
and
global
warming
produce
abiotic
stressors
that
affect
plant
development
productivity.
Abiotic
stressors,
such
as
drought,
salt,
cold,
heat,
significantly
impair
agricultural
crop
yields.
The
endophyte
is
a
type
of
endosymbiont,
usually
bacteria
or
fungus
lives
inside
cells
doesn't
cause
disease
in
the
host
plant.
This
review
scrutinizes
integral
contribution
endophytes
to
augmenting
stress
tolerance
plants.
core
analysis
investigates
regulatory
role
mechanism
pivotal
physiological
aspects
plants
under
conditions.
includes
their
involvement
managing
water
uptake
maintaining
balance
during
drought
salinity
stress,
regulating
osmotic
scavenging
reactive
oxygen
species
(ROS).
Additionally,
explores
outlines
diverse
strategies
for
inoculating
applying
enhance
Endophytes
secondary
active
compounds
defend
from
diseases
extracellular
enzymes
help
colonize
hosts.
Microbial
may
thrive
poor
soil
conditions
through
phytohormone
production
hazardous
chemical
degradation.
use
many
processes
survive
nutritional
deficiency,
heavy
metal
temperature.
These
findings
suggest
rhizobacteria
cope
with
stress.
Still,
more
research
needed
understand
mechanisms
side
effects
maximize
sustainable
climate-smart
agriculture.
Biomolecules,
Год журнала:
2023,
Номер
13(7), С. 1038 - 1038
Опубликована: Июнь 25, 2023
The
seminal
discovery
of
paclitaxel
from
endophytic
fungus
Taxomyces
andreanae
was
a
milestone
in
recognizing
the
immense
potential
fungi
as
prolific
producers
bioactive
secondary
metabolites
use
medicine,
agriculture,
and
food
industries.
Following
paclitaxel,
research
community
has
intensified
efforts
to
harness
putative
lead
molecules
with
anticancer,
anti-inflammatory,
antimicrobial,
antioxidant,
cardio-protective,
immunomodulatory
properties.
Endophytic
have
been
valuable
source
compounds
over
last
three
decades.
Compounds
such
taxol,
podophyllotoxin,
huperzine,
camptothecin,
resveratrol
effectively
isolated
characterized
after
extraction
fungi.
These
findings
expanded
applications
medicine
related
fields.
In
present
review,
we
systematically
compile
analyze
several
important
derived
fungi,
encompassing
period
2011
2022.
Our
systematic
approach
focuses
on
elucidating
origins
exploring
structural
diversity
biological
activities
exhibited
by
these
compounds,
giving
special
emphasis
pharmacological
mechanism
action
certain
compounds.
We
highlight
tremendous
alternate
sources
metabolites,
implications
for
combating
major
global
diseases.
This
underscores
significant
role
that
can
play
development
novel
therapeutic
agents
address
challenges
posed
prevalent
diseases
worldwide.
Antibiotics,
Год журнала:
2024,
Номер
13(3), С. 271 - 271
Опубликована: Март 18, 2024
Infectious
diseases
are
a
significant
challenge
to
global
healthcare,
especially
in
the
face
of
increasing
antibiotic
resistance.
This
urgent
issue
requires
continuous
exploration
and
development
new
antimicrobial
drugs.
In
this
regard,
secondary
metabolites
derived
from
endophytic
microorganisms
stand
out
as
promising
sources
for
finding
antimicrobials.
Endophytic
microorganisms,
residing
within
internal
tissues
plants,
have
demonstrated
capacity
produce
diverse
bioactive
compounds
with
substantial
pharmacological
potential.
Therefore,
numerous
been
isolated
endophytes,
particularly
fungi
actinomycetes.
However,
only
limited
number
these
subjected
comprehensive
studies
regarding
their
mechanisms
action
against
bacterial
cells.
Furthermore,
investigation
effects
on
antibiotic-resistant
bacteria
identification
biosynthetic
gene
clusters
responsible
synthesizing
conducted
subset
compounds.
Through
analysis
current
research
findings,
review
describes
drugs
antibacterial
activities
natural
endophytes
bacteria,
synthesis
metabolites.
Applied Sciences,
Год журнала:
2025,
Номер
15(7), С. 3516 - 3516
Опубликована: Март 23, 2025
This
research
explored
the
potential
of
plant
antimicrobial
compounds
as
natural
alternatives
to
synthetic
antimicrobials
in
food
and
pharmaceutical
industries,
emphasizing
urgent
need
combat
resistance.
It
detailed
various
mechanisms
by
which
these
plant-derived
inhibit
microbial
growth,
including
disrupting
cell
membrane
integrity,
impeding
wall
protein
synthesis,
preventing
biofilm
formation,
ultimately
leading
bacterial
death.
study
highlighted
specific
effects
on
cells,
such
inhibiting
cellular
respiration,
motility,
while
also
modulating
oxygen
consumption
reactive
species
generation,
are
vital
addressing
biofilm-mediated
infections.
Additionally,
can
regulate
expression
virulence
factors
efflux
pumps,
enhancing
antibiotic
efficacy.
A
bibliometric
analysis
revealed
a
growing
trend
output
international
collaboration,
particularly
from
China
United
States,
with
key
journals
“Frontiers
Microbiology”
“Antimicrobial
Agents
Chemotherapy.”
The
identified
six
clusters
related
research,
underscoring
for
further
investigation
into
applications
bioactive
compounds.
In
conclusion,
understanding
action
is
important
their
effective
application
combating
Encyclopedia,
Год журнала:
2023,
Номер
3(2), С. 759 - 780
Опубликована: Июнь 19, 2023
There
has
been
renewed
interest
in
the
application
of
endophytic
fungi
to
control
phytopathogenic
fungi,
which
cause
significant
damage
crop
health,
ultimately
leading
losses
agricultural
productivity.
Endophytic
inhibit
pathogens
via
different
modes
action—mycoparasitism,
competition
(for
nutrients
and
ecological
niches),
antibiosis,
induction
plant
defense—thus
demonstrating
ability
a
wide
range
growth
phases
habitats.
However,
many
studies
have
conducted
under
laboratory
conditions,
there
is
huge
lack
real
field
testing
was
performed.
Aspergillus,
Clonostachys,
Coniothyrium,
Trichoderma,
Verticillium
proven
be
most
effective
fungal
biocontrol
agents.
Trichoderma
regarded
as
promising
group
commercial
formulations.
In
this
study,
we
attempted
emphasize
significance
endophytes
controlling
while
reporting
recent
advances
biology
application.
Critical Reviews in Biotechnology,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Май 6, 2024
The
rapid
increase
in
antimicrobial
resistance
(AMR)
projects
a
"global
emergency"
and
necessitates
need
to
discover
alternative
resources
for
combating
drug-resistant
pathogens
or
"superbugs."
One
of
the
key
themes
"One
Health
Concept"
is
based
on
fact
that
interconnected
network
humans,
environment,
animal
habitats
majorly
contribute
selection
spread
AMR.
Moreover,
injudicious
overuse
antibiotics
healthcare,
associated
disciplines,
further
aggravates
concern.
prevalence
persistence
AMR
global
economic
burden
are
constantly
witnessing
an
upsurge
due
fewer
therapeutic
options,
rising
mortality
statistics,
expensive
healthcare.
present
decade
has
witnessed
extensive
exploration
utilization
bio-based
harnessing
potential
efficacies.
discovery
characterization
diverse
chemical
entities
from
endophytes
as
potent
antimicrobials
define
important
yet
less-explored
area
natural
product-mediated
drug
discovery.
Endophytes-produced
show
efficacies
targeting
microbial
synthetic
biology
(SB)
mediated
engineering
yield
enhancement,
forms
prospective
research.
In
keeping
with
urgent
requirements
new/novel
growing
concerns
about
pathogenic
microbes
AMR,
this
paper
comprehensively
reviews
emerging
trends,
prospects,
challenges
their
effective
production
via
SB.
This
literature
review
would
serve
platform
novel
bioactive
biological
organisms
"novel
therapeutics"
address
Archives of Phytopathology and Plant Protection,
Год журнала:
2025,
Номер
unknown, С. 1 - 26
Опубликована: Фев. 2, 2025
Blight
disease
caused
by
Alternaria
brassicae
reduces
the
production
of
Brassica
juncea
L.
to
great
extent.
Biological
control
agents
can
be
used
as
good
substitutes
for
chemical
pesticides.
In
present
study,
thirty-eight
endophytic
bacteria
were
isolated
from
B.
Isolate
SS7
identified
Pseudomonas
azotoformans
was
selected
based
on
its
biocontrol
and
plant
growth-promoting
characteristics.
Scanning
electron
microscopy
showed
structural
abnormalities
in
A.
bacterial
isolate.
FTIR
GCMS
revealed
presence
17
active
compounds
that
involved
activity.
Pot
experiment
a
significant
increase
growth
phytochemical
parameters
reduced
incidence
up
32%
plants
treated
with
isolate
brassicae.
effective
promoting
agent
infection
via
diffusible
volatile
antifungal
compounds.
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 161 - 161
Опубликована: Март 31, 2024
Bacillus
cereus,
a
common
food-borne
pathogen,
forms
biofilms
and
generates
virulence
factors
through
quorum
sensing
(QS)
mechanism.
In
this
study,
six
compounds
(dankasterone
A,
demethylincisterol
A3,
zinnimidine,
cyclo-(L-Val-L-Pro),
cyclo-(L-Ile-L-Pro),
cyclo-(L-Leu-L-Pro))
were
isolated
from
the
endophytic
fungus
Pithomyces
sacchari
of
Laurencia
sp.
in
South
China
Sea.
Among
them,
sterol
derivative,
exhibited
strong
QS
inhibitory
activity
against
B.
cereus.
The
A3
was
evaluated
experiments.
minimum
concentration
(MIC)
cereus
6.25
μg/mL.
At
sub-MIC
concentrations,
it
significantly
decreased
biofilm
formation,
hindered
mobility,
diminished
production
protease
hemolysin
activity.
Moreover,
RT-qPCR
results
demonstrated
that
markedly
inhibited
expression
QS-related
genes
(plcR
papR)
exposure
to
resulted
downregulation
(comER,
tasA,
rpoN,
sinR,
codY,
nheA,
hblD,
cytK)
associated
with
factors.
Hence,
is
potentially
effective
compound
pipeline
innovative
antimicrobial
therapies.
