Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment

Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер 51, С. 104472 - 104472

Опубликована: Янв. 5, 2025

Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma. To systematically evaluate existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality strength while performing updated to refine outcomes. PubMed, EMBASE, Cochrane Library, Web Science were searched up September 18, 2024, identify clinical patients The random-effects model was employed re-synthesize meta-analyses, comprehensive evaluation methodological quality. Updated data conducted, including subgroup analyses stratified by cholangiocarcinoma type intervention modality. A total 5 21 included. findings indicated that combining stenting or chemotherapy can significantly improve overall reduce mortality rate, without increasing risk adverse events (AEs) such as cholangitis abscess formation. For extrahepatic adding notable improvement 2-year rate. Meanwhile, hilar addition showed more pronounced enhancement 1-year Current indicates combined decreases enhances OS incidence AEs. Adding may be beneficial long-term efficacy.

Язык: Английский

---

Biliary tract cancers: a descriptive study in the population treated at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) between 2009 and 2021

Academia oncology., Год журнала: 2025, Номер 2(1)

Опубликована: Фев. 19, 2025

Introduction: Biliary tract cancers (BTCs) are associated with a poor prognosis and lack of standardized management guidelines in Canada, resulting variable care influenced by age, ethnicity, region. This study analyzes BTC demographics, diagnostics, treatment modalities, survival outcomes at the Centre Hospitalier Universitaire de Sherbrooke (CHUS), Quebec. Methods: A retrospective from 2009 to 2021 included patients aged 18 older diagnosed carcinoma-type BTCs treated CHUS. Results: total 218 were our study. The median age diagnosis was 70.7 years, 48.6% being male 51.4% female. In population, extrahepatic cholangiocarcinomas most frequently (31.7%), followed intrahepatic (29.8%), gallbladder carcinomas (19.7%), Ampulla Vater (16.1%). Identifiable risk factors very rare. Computed tomography (CT) scans primary diagnostic tool (98.1%). Surgical resection performed 35.3% patients, 40.4% received chemotherapy. overall 10.2 months, 1-year rate 46%. Patients cancer had longest 55 months. improved for all biliary subtypes, reaching 52 Conclusions: CHUS show diverse demographics types, mirroring national trends. Early detection surgical enhance survival. Ongoing research is essential improve explore its complex causes.

Язык: Английский

---

Pancreatic neuroendocrine neoplasms coexisting with biliary intraductal papillary mucinous neoplasm: A case report and review of literature

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(4)

Опубликована: Март 24, 2025

Pancreatic neuroendocrine neoplasms (pNENs) are rare, heterogeneous tumors accounting for 1%-2% of pancreatic tumors, with significant malignant potential. Intraductal papillary mucinous neoplasm the bile duct (IPMN-B) is a rare precancerous lesion in system, potential malignancy. The combination pNENs and IPMN-B exceptionally often leads to misdiagnosis. This study aims report case combined treated at Yanbian University Hospital improve understanding management this unusual tumor combination. We retrospectively analyzed from Hospital. reviewed clinical records, imaging findings, endoscopic retrograde cholangiopancreatography, surgical exploration, histopathological examination. patient was diagnosed IPMN-B. Surgical treatment performed, follow-up showing effective no recurrence. represents first It highlights need thorough diagnostic evaluation prevent misdiagnosis strategies.

Язык: Английский

---

Prognosis of patients with advanced bile tract carcinoma: assessment using the modified-Gustave Roussy Immune Score (mGRIm-s) as a clinico-immunological tool

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(5)

Опубликована: Май 9, 2024

The emergence of immune checkpoint inhibitors (ICIs) has enhanced survival outcomes for certain patients with advanced biliary tract carcinoma (BTC). Pinpointing those who would benefit most from immunotherapy remains elusive. We investigated the predictive value modified Gustave Roussy Immune Score (mGRIm-s) in BTC treated ICIs.

Язык: Английский

---

Residual biliary intraepithelial neoplasia without malignant transformation at resection margin for perihilar cholangiocarcinoma does not require expanded resection: a dual center retrospective study

World Journal of Surgical Oncology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 21, 2024

Additional resection for invasive cancer at perihilar cholangiocarcinoma (pCCA) margins has become a consensus. However, controversy still exists regarding whether additional is necessary residual biliary intraepithelial neoplasia (BilIN).

Язык: Английский

---

Gut Microbiome and Bile Acid Interactions: Mechanistic Implications for Cholangiocarcinoma Development, Immune Resistance, and Therapy

American Journal Of Pathology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

---

Prognostic Significance of CD11b-, CD8-, and CD163-Positive Tumor-Infiltrating Immune Cells in Distal Bile Duct Cancer

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(10), С. 1033 - 1033

Опубликована: Сен. 27, 2024

: Distal bile duct cancer is an aggressive malignancy. Tumor-infiltrating immune cells (TIICs) in the tumor microenvironment are crucial for predicting prognosis various cancers. In this study, we analyzed TIICs based on CD11b, CD163, and CD8 expression, evaluated their association with clinicopathologic factors distal cancer.

Язык: Английский

---