Comparison of sinonasal symptoms in upper respiratory tract infections during the infectious diseases season of November 2023 to March 2024—a cross-sectional study DOI Creative Commons
Marcin Straburzyński, Anna Romaszko–Wojtowicz

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Авг. 29, 2024

Introduction Upper respiratory tract infections (URTIs) are among the most common reasons for patients consulting a general practitioner (GP) during infectious diseases season, with viruses being predominant cause. The COVID-19 pandemic has significantly impacted GPs’ perception of these infections. pandemic’s progression, especially emergence Omicron variant, complicated diagnosis and treatment URTIs, evolving symptoms. Aim aim this study was to assess differences in symptoms reported by various infections, such as COVID-19, influenza, cold, post-viral rhinosinusitis, season November 2023 March 2024. Materials methods conducted primary health care clinic, providing population approximately 10,000 people, adult presenting URTI 2023/2024 season. Patients qualified were swabbed SARS-CoV-2, influenza A B syncytial virus (RSV) antigens. Symptoms assessed use semi-structured questionnaire. Results Of 1810 276 included study. Among nasal obstruction ( p = 0.005) discharge 0.001) less than those or cold. However, more frequent who had confirmed previous immunization (COVID-19 history vaccination) 0.028). Conclusion incidence individual sinonasal varies depending on aetiological agent URTI. This observation may not only help clinicians make correct diagnosis, but also suggests an inflammatory response mucosa paranasal sinuses that is dependent agent. indicates altered within same species following immunization. Limitations study’s limitations include small sample size (276 patients), focus one GP practice, reliance clinical signs antigen tests. Nonetheless, findings provide valuable insights. Further research larger patient groups extended follow-up periods required confirm findings.

Язык: Английский

Prevalence of Olfactory Dysfunction with the Omicron Variant of SARS-CoV-2: A Systematic Review and Meta-Analysis DOI Creative Commons
Christopher S. von Bartheld,

Lingchen Wang

Cells, Год журнала: 2023, Номер 12(3), С. 430 - 430

Опубликована: Янв. 28, 2023

The omicron variant is thought to cause less olfactory dysfunction than previous variants of SARS-CoV-2, but the reported prevalence differs greatly between populations and studies. Our systematic review meta-analysis provide information regarding regional differences in as well an estimate global based on 62 studies reporting 626,035 patients infected with variant. omicron-induced European ancestry 11.7%, while it significantly lower all other populations, ranging 1.9% 4.9%. When ethnic population sizes are considered, adults estimated be 3.7%. Omicron's effect olfaction twofold tenfold that alpha or delta according meta-analyses our analysis directly compared variants. profile ethnicities mirrors results a recent genome-wide association study connected gene locus encoding odorant-metabolizing enzyme, UDP glycosyltransferase, extent COVID-19-related loss smell. consistent hypothesis this enzyme contributes observed differences.

Язык: Английский

Процитировано

43
The immune mechanism of the nasal epithelium in COVID-19–related olfactory dysfunction DOI Creative Commons
Shunmei Chen,

Shufen Wang

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 17, 2023

During the first waves of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection, olfactory dysfunction (OD) was reported as a frequent clinical sign. The nasal epithelium is one front-line protections against viral infections, and immune responses mucosa may be associated with OD. Two mechanisms underlying OD occurrence in COVID-19 have been proposed: infection sustentacular cells inflammatory reaction epithelium. former triggers latter likely prolongs These two alternative act parallel; more important for because are to entry point SARS-CoV-2 than neurons susceptible early injury. Furthermore, abundantly express transmembrane protease, serine (TMPRSS2) play major role has revealed crucial roles cells. This review aims elucidate how contribute COVID-19–related Understanding aid development improved medical treatments

Язык: Английский

Процитировано

11
SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology DOI Creative Commons
Serigne Fallou Wade, Abou Abdallah Malick Diouara,

Babacar Ngom

и другие.

Microorganisms, Год журнала: 2024, Номер 12(3), С. 540 - 540

Опубликована: Март 7, 2024

Acute respiratory viruses (ARVs) are the leading cause of diseases in humans worldwide. High-risk individuals, including children and elderly, could potentially develop severe illnesses that result hospitalization or death worst case. The most common ARVs Human syncytial virus, Metapneumovirus, Parainfluenza Virus, rhinovirus, coronaviruses (including SARS MERS CoV), adenoviruses, Bocavirus, enterovirus (-D68 71), influenza viruses. olfactory deficits due to ARV infection a symptom among patients. This review provides an overview role SARS-CoV-2 other development human pathophysiology. We highlight critical need understand signaling underlying dysfunction therapeutics for this wide-ranging category AVRs restore altered loss smell affected

Язык: Английский

Процитировано

3
Prediction and Evaluation of Coronavirus and Human Protein–Protein Interactions Integrating Five Different Computational Methods DOI
Binghua Li, Xiaoyu Li, Xian Tang

и другие.

Proteins Structure Function and Bioinformatics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

ABSTRACT The high lethality and infectiousness of coronaviruses, particularly SARS‐Cov‐2, pose a significant threat to human society. Understanding especially the interactions between these viruses humans, is crucial for mitigating coronavirus pandemic. In this study, we conducted comprehensive comparison evaluation five prevalent computational methods: interolog mapping, domain‐domain interaction methodology, domain‐motif structure‐based approaches, machine learning techniques. These methods were assessed using unbiased datasets that include C1, C2h, C2v, C3 test sets. Ultimately, integrated methodologies into unified model predicting protein–protein (PPIs) coronaviruses proteins. Our final demonstrates relatively better performance, with C2v sets, which are frequently used in practical applications. Based on model, further established high‐confidence PPI network consisting 18,012 3843 proteins 129 reliability our predictions was validated through current knowledge framework analysis. This study anticipated enhance mechanistic understanding coronavirus‐human relationship while facilitating rediscovery antiviral drug targets. source codes accessible at https://github.com/covhppilab/CoVHPPI .

Язык: Английский

Процитировано

0
Prevalence of Olfactory Dysfunction with the Omicron Variant of SARS-CoV-2: A Systematic Review and Meta-analysis DOI Creative Commons
Christopher S. von Bartheld,

Lingchen Wang

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Дек. 16, 2022

Abstract The omicron variant is thought to cause less olfactory dysfunction than previous variants of SARS-CoV-2, but the reported prevalence differs greatly between populations and studies. Our systematic review meta-analysis provide information about regional differences in as well an estimate global based on 62 studies reporting 626,035 patients infected with variant. omicron-induced European ancestry 11.7%, while it significantly lower all other populations, ranging 1.9% 4.9%. When ethnic population sizes are taken into account, adults estimated at 3.7%. Omicron’s effect olfaction twofold tenfold that alpha or delta variant, according meta-analyses our analysis directly compared variants. profile ethnicities mirrors results a recent genome-wide association study implicated gene locus encoding odorant-metabolizing enzyme, UDP glycosyltransferase, be linked extent COVID-related loss smell. consistent hypothesis this enzyme contributes observed differences.

Язык: Английский

Процитировано

8
Neuropsychiatric Burden of SARS-CoV-2: A Review of Its Physiopathology, Underlying Mechanisms, and Management Strategies DOI Creative Commons

Aliteia-Maria Pacnejer,

Anca Butucă, Carmen Maximiliana Dobrea

и другие.

Viruses, Год журнала: 2024, Номер 16(12), С. 1811 - 1811

Опубликована: Ноя. 21, 2024

The COVID-19 outbreak, caused by the SARS-CoV-2 virus, was linked to significant neurological and psychiatric manifestations. This review examines physiopathological mechanisms underlying these neuropsychiatric outcomes discusses current management strategies. Primarily a respiratory disease, frequently leads issues, including cephalalgia migraines, loss of sensory perception, cerebrovascular accidents, impairment such as encephalopathy. Lasting neuropsychological effects have also been recorded in individuals following infection. These include anxiety, depression, cognitive dysfunction, suggesting lasting impact on mental health. neuroinvasive potential inflammatory responses, role angiotensin-converting enzyme 2 (ACE2) neuroinflammation are critical factors In addition, highlights importance monitoring biomarkers assess Central Nervous System (CNS) involvement. Management strategies for conditions supportive therapy, antiepileptic drugs, antithrombotic psychotropic emphasizing need multidisciplinary approach. Understanding long-term implications is essential developing effective treatment protocols improving patient outcomes.

Язык: Английский

Процитировано

1
Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 during Omicron variant pandemic in China DOI Creative Commons
Ying Chen, Yuying Chen, Lixin Chen

и другие.

Heliyon, Год журнала: 2023, Номер 9(10), С. e20715 - e20715

Опубликована: Окт. 1, 2023

Chemosensory disorders (including smell, taste and chemesthesis) are among the established symptoms of COVID-19 infection; however, new data indicate that changes in chemosensory sensation caused by may differ populations variants. To date, few studies have focused on influence SARS-CoV-2 Omicron variant qualitative quantitative reductions function China. We conducted a cross-sectional study patients with variant, to investigate prevalence before during infection, using an online questionnaire. A total 1245 completed survey. The rates taste, chemesthesis were 69.2%, 67.7%, 31.4%, respectively. Our sex, age, smoking, COVID-19-related symptoms, such as lack appetite, dyspnea, fatigue, be associated COVID-19. Self-rating revealed experienced general decline function. Further longitudinal research needed generate additional based objective assessment factors influencing

Язык: Английский

Процитировано

3
Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China DOI Open Access
Ying Chen, Yuying Chen, Xiang Liu

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Фев. 23, 2023

SUMMARY Background Chemosensory disorders (including smell, taste and chemesthesis) are among the established symptoms of COVID-19 infection; however, new data indicate that changes in chemosensory sensation caused by may differ populations variants. To date, few studies have focused on influence SARS-CoV-2 Omicron variant qualitative quantitative reductions function China. Methodology We conducted a cross sectional study patients with variant, to investigate prevalence before during infection, using an online questionnaire. Results A total 1245 completed survey. The rates taste, chemesthesis were 69.2%, 67.7%, 31.4%, respectively. Our sex, age, smoking, COVID-19-related symptoms, such as lack appetite, dyspnea, fatigue, be associated COVID-19. Conclusions Self-rating revealed experienced general decline function. Further longitudinal research needed generate additional based objective assessment factors influencing

Язык: Английский

Процитировано

2
SARS-CoV-2 and Other Respiratory Viruses in Human Olfactory Pathophysiology DOI Open Access
Serigne Fallou Wade, Abou Abdallah Malick Diouara,

Babacar Ngom

и другие.

Опубликована: Окт. 16, 2023

Acute respiratory viruses (ARVs) are leading cause of diseases in human worldwide. High risk individuals including children and elderly could potentially develop severe illness that result hospitalization or death the worst case. Most common ARVs Human syncytial virus, Metapneumovirus, Parainfluenza Virus, rhinovirus, coronaviruses (including SARS MERS CoV), adenoviruses, Bocavirus, enterovirus (-D68 71), influenza viruses. The olfactory deficits due to infection is a symptom among patients. This mini review provides an overview role SARS-CoV-2 other development pathophysiology. We highlight critical need for understanding signaling underlying dysfunction therapeutics this wide-ranging category AVRs restore altered loss smell affected

Язык: Английский

Процитировано

1
Comparison of sinonasal symptoms in upper respiratory tract infections during the infectious diseases season of November 2023 to March 2024—a cross-sectional study DOI Creative Commons
Marcin Straburzyński, Anna Romaszko–Wojtowicz

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Авг. 29, 2024

Introduction Upper respiratory tract infections (URTIs) are among the most common reasons for patients consulting a general practitioner (GP) during infectious diseases season, with viruses being predominant cause. The COVID-19 pandemic has significantly impacted GPs’ perception of these infections. pandemic’s progression, especially emergence Omicron variant, complicated diagnosis and treatment URTIs, evolving symptoms. Aim aim this study was to assess differences in symptoms reported by various infections, such as COVID-19, influenza, cold, post-viral rhinosinusitis, season November 2023 March 2024. Materials methods conducted primary health care clinic, providing population approximately 10,000 people, adult presenting URTI 2023/2024 season. Patients qualified were swabbed SARS-CoV-2, influenza A B syncytial virus (RSV) antigens. Symptoms assessed use semi-structured questionnaire. Results Of 1810 276 included study. Among nasal obstruction ( p = 0.005) discharge 0.001) less than those or cold. However, more frequent who had confirmed previous immunization (COVID-19 history vaccination) 0.028). Conclusion incidence individual sinonasal varies depending on aetiological agent URTI. This observation may not only help clinicians make correct diagnosis, but also suggests an inflammatory response mucosa paranasal sinuses that is dependent agent. indicates altered within same species following immunization. Limitations study’s limitations include small sample size (276 patients), focus one GP practice, reliance clinical signs antigen tests. Nonetheless, findings provide valuable insights. Further research larger patient groups extended follow-up periods required confirm findings.

Язык: Английский

Процитировано

0