Natural Products as Modulators of Aryl Hydrocarbon Receptor Signaling in Atopic Dermatitis Management DOI Creative Commons
Jangho Lee, Hyo‐Kyoung Choi, Hee Soon Shin

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 5951 - 5951

Опубликована: Дек. 17, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by immune dysregulation, barrier dysfunction, and significant patient burden. Recent studies have highlighted the aryl hydrocarbon receptor (AhR) as promising therapeutic target for AD management because of its pivotal role in modulating responses maintaining integrity. The dysfunction AhR pathway has been linked to pathogenesis, emphasizing need therapies that can restore regulatory functions. Natural products emerged potential modulators are effective safe alternatives conventional treatments. Compounds such curcumin, resveratrol, quercetin, microbial metabolites demonstrated ability activate AhR, reduce inflammation, promote function. These natural agents fewer side effects enhance compliance compared with therapies, making them attractive candidates long-term management. integration targeting provides multifaceted approach alleviates symptoms, addresses underlying disease mechanisms, promotes sustainable improvements health. This review highlights their roles enhancing outcomes through novel integrative treatment strategies.

Язык: Английский

Atopic dermatitis - the review DOI Creative Commons

Joanna Wrona,

Aleksandra Kaźmierczyk, Jędrzej Kęsik

и другие.

Quality in Sport, Год журнала: 2025, Номер 37, С. 56851 - 56851

Опубликована: Янв. 3, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by disrupted epidermal barrier, immune dysregulation, and genetic predisposition. Affecting individuals across all age groups, AD presents with recurrent flare-ups varying clinical patterns depending on age. The pathophysiology involves key elements such as loss-of-function mutations in the filaggrin (FLG) gene, overproduction of cytokines like IL-4 IL-13, colonization Staphylococcus aureus. Management strategies include patient education, topical therapies (e.g., corticosteroids, calcineurin inhibitors, crisaborole, tapinarof), systemic treatments dupilumab methotrexate, phototherapy for refractory cases. Preventive measures, including breastfeeding probiotic supplementation, offer limited benefits, emphasizing need individualized approaches. Innovative further research into pathogenesis hold promise more effective disease control improved quality life patients.

Язык: Английский

Процитировано

0
Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights DOI Creative Commons
Heidi M. Abdel-Mageed

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Язык: Английский

Процитировано

0
Current options and treatment strategies for alopecia ateata in comorbidity with atopic diseases DOI Creative Commons
Н. Н. Потекаев, G. P. Tereshchenko, E. R. Gumennaia

и другие.

Meditsinskiy sovet = Medical Council, Год журнала: 2025, Номер 2, С. 143 - 152

Опубликована: Март 31, 2025

Introduction. Alopecia areata (AA) associated with atopic diseases (AD) is characterized by specific clinical, epidemiological, and immunological features, allowing the identification of an “atopic type” AA. Currently, certain treatment methods may be effective for both AA AD. Aim. To analyze current options “atopic” based on literature clinical experience. Materials methods. Review publications concerning connection between atopy methods; assessment laboratory data outcomes patients Results. Seventy-eight were analyzed, two cases described. In first case, a patient receiving dupilumab showed positive effects universal AA, dermatitis (AtD), bronchial asthma. The second AtD subtotal achieved partial remission through combined therapy, including UVB 311 nm antihistamines. Specific comorbid AD identified. Notably, phototherapy used aid in hair restoration; antihistamines symptoms are potentially particularly during active stage. For systemic therapy needs AtD, oral JAK inhibitors – baricitinib, upadacitinib, abrocitinib should considered. Dupilumab choice severe respiratory allergies, younger pediatric patients. Conclusions. strategy concomitant focus reducing pharmacological burden improving quality life. Modern therapeutic approaches provide addressing shared pathological mechanisms while considering severity age.

Язык: Английский

Процитировано

0
Natural Products as Modulators of Aryl Hydrocarbon Receptor Signaling in Atopic Dermatitis Management DOI Creative Commons
Jangho Lee, Hyo‐Kyoung Choi, Hee Soon Shin

и другие.

Molecules, Год журнала: 2024, Номер 29(24), С. 5951 - 5951

Опубликована: Дек. 17, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by immune dysregulation, barrier dysfunction, and significant patient burden. Recent studies have highlighted the aryl hydrocarbon receptor (AhR) as promising therapeutic target for AD management because of its pivotal role in modulating responses maintaining integrity. The dysfunction AhR pathway has been linked to pathogenesis, emphasizing need therapies that can restore regulatory functions. Natural products emerged potential modulators are effective safe alternatives conventional treatments. Compounds such curcumin, resveratrol, quercetin, microbial metabolites demonstrated ability activate AhR, reduce inflammation, promote function. These natural agents fewer side effects enhance compliance compared with therapies, making them attractive candidates long-term management. integration targeting provides multifaceted approach alleviates symptoms, addresses underlying disease mechanisms, promotes sustainable improvements health. This review highlights their roles enhancing outcomes through novel integrative treatment strategies.

Язык: Английский

Процитировано

0