Glutamate and obesity – what is the link?

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2023, Номер 27(1), С. 70 - 76

Опубликована: Ноя. 8, 2023

Purpose of review Many studies using metabolomics have tried to unravel the metabolic signature obesity and understand pathophysiology this complex heterogeneous disease. Circulating levels amino acid glutamate been consistently associated with more specifically measurements abdominal fat accumulation. The purpose narrative is highlight recent documenting association. Recent findings concentrations positively correlated central accumulation such as waist circumference visceral adipose tissue area. Moreover, elevated linked a higher prevalence type 2 diabetes, cardiovascular diseases nonalcoholic fatty liver association adiposity detected in early life, genetic predisposition does not appear major driver. Glutamate reflect vivo synthesis rather than dietary intake. However, interventions generating improvements incretin receptor agonist treatment or may reduce plasma acid. Summary confirm consistent between circulating its cardiometabolic complications. pathophysiological pathways underlying phenomenon are still unclear. Furthermore, needed establish usefulness analyte biomarker obesity.

Язык: Английский

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Dapagliflozin promotes white adipose tissue browning though regulating angiogenesis in high fat induced obese mice

BMC Pharmacology and Toxicology, Год журнала: 2024, Номер 25(1)

Опубликована: Март 19, 2024

Abstract Browning of white adipose tissue (WAT) is become an appealing target for therapeutics in the treatment obesity and related metabolic diseases. Dapagliflozin widely used type 2 diabetes, it also found that drug exhibits regulate systemic metabolism such as obesity, insulin resistance hepatic steatosis. However, precise role dapagliflozin on WAT remodeling remains to be elucidated. The current study aimed explore browning high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice ( n = 6 per group) were establish model by following feeding with HFD weeks. randomly treated or without experimental observation. volume fat fraction quantified, H&E, UCP-1 staining immunohistochemistry conducted investigate white-to-brown conversion angiogenesis respectively. Quantitative real-time polymerase chain reaction (qPCR) was employed mRNA expression levels genes WAT. Subsequently, 3T3-L1 cells effect preadipocytes differentiation vitro. Our results demonstrated could reduce body weight gain promote induced via regulating lipogenesis Furthermore, differentiation, up-regulate adipocytes In conclusion, can potentially improving

Язык: Английский

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Changes in the triglyceride-glucose-body mass index estimate the risk of hypertension among the middle-aged and older population: a prospective nationwide cohort study in China in the framework of predictive, preventive, and personalized medicine

The EPMA Journal, Год журнала: 2024, Номер 15(4), С. 611 - 627

Опубликована: Окт. 8, 2024

Язык: Английский

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Ultra-processed foods intake in relation to metabolic health status, serum brain-derived neurotrophic factor and adropin levels in adults

Nutrition Journal, Год журнала: 2024, Номер 23(1)

Опубликована: Окт. 9, 2024

In recent years, there has been a lot of discussion over the impact ultra-processed foods (UPFs) intake on overall health subjects. However, association between UPFs and metabolic unhealthy (MU) status is still in state ambiguity. The current study assessed relationship MU with regard to brain-derived neurotrophic factor (BDNF) adropin levels.

Язык: Английский

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Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure

Current Hypertension Reports, Год журнала: 2024, Номер 26(9), С. 381 - 388

Опубликована: Апрель 20, 2024

Abstract Purpose of the Review Preserved ejection fraction heart failure and obesity frequently coexist. Whether plays a consistent role in pathogenesis preserved is unclear. Accumulation visceral adiposity underlies pathogenic aftermaths obesity. However, imaging assessed by computed tomography or magnetic resonance thus not routinely available. In contrast, epicardial thickness echocardiography We review rationale for assessing patients with elevated body mass index. Recent Findings Body index correlates poorly visceral, adiposity. Visceral enlarges as progresses. Epicardial may hasten progression coronary artery disease impairs left ventricular sub-endocardial perfusion diastolic function. Summary help monitor therapeutic response

Язык: Английский

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Relationship of fat mass index and fat free mass index with body mass index and association with sleeping patterns and physical activity in Saudi young adults women

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Март 5, 2025

To analyze the association between Fat Mass Index (FMI), Free (FFMI), Mass/Fat (FFM/FM), and Body (BMI) among young adult Saudi women to explore how these body composition indices are associated with sleep physical activity patterns. A total of 1,741 university female students participated in this cross-sectional study. was measured using InBody 270 analyzer. FMI, FFMI, FM/FFM were classified into tertiles (T1, T2, T3), T1 as lowest T3 highest tertile. Sleep quality duration assessed Pittsburgh Quality Index, while an exercise vital sign tool. BMI increased significantly from Tertile 1 3 across all groups for FMI FFMI (p < 0.001), a decrease observed 0.001). Conversely, FFM third tertile No significant associations found or indices, even after adjusting age BMI. However, frequency composition, particularly FMI. These became more pronounced The findings highlight strong patterns women. While did not show relationships results emphasize importance regular maintaining healthy composition. insights underline need targeted interventions promoting support optimal health well-being population.

Язык: Английский

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Distinct Effects of Wheat and Black Bean Consumption on Postprandial Vascular Responses in People with Arterial Stiffness: A Pilot Randomized Cross-Over Study

Nutrients, Год журнала: 2025, Номер 17(7), С. 1159 - 1159

Опубликована: Март 27, 2025

Background/Objective: Postprandial vascular responses impact health. This study investigated whether eating pulses or whole grains can acutely relax blood vessels in people with arterial stiffness. Methods: A single-blinded, controlled randomized cross-over clinical trial was conducted to compare the effects of (¾ cup black beans) versus wheat kernels, also known as berries) white rice cup) on postprandial males and females established stiffness (n = 9, 3M/6F, 50-64 years old). Peripheral central hemodynamic measurements were obtained non-invasively prior 2 h after food consumption compared by t-test within a type. Results: systolic pressure increased (4%) but not beans. marked decline augmentation index at 75 bpm (arterial stiffness) from 26.1 ± 3.6% 16.2 2.0% observed beans rice. All foods slightly decreased heart rate had limited other parameters circulatory Conclusions: Eating improved overall health when The distinct, having major positive effect vessel findings suggest that regular inclusion both diet would be beneficial for improving cardiovascular persons exhibiting signs dysfunction, thus providing potential therapeutic benefit individuals who are risk attack stroke. registered (NCT05818358) ClinicalTrials.gov.

Язык: Английский

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Preliminary effects and feasibility of online interactive Baduanjin exercise in adults with overweight and obesity: a pilot randomized controlled trial

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Overweight and obesity are chronic conditions with severe health implications, demanding effective sustainable management strategies. The escalated Baduanjin, an adapted form of traditional is proposed as a targeted intervention for individuals overweight obesity, offering potentially accessible approach to weight overall improvement. This pilot study aimed assess the preliminary effects feasibility online interactive Baduanjin exercise program, focus on participant engagement acceptance. A 12-week randomized controlled trial was conducted in Guangzhou, China, from June 30 November 15, 2023, involving 50 participants obesity. Participants were randomly allocated group (n=26) or control (n=24). received three 60-minute exercises per week 12 weeks, addition education. only education, delivered sessions over period. primary outcome change body mass index (BMI) baseline 12. Secondary outcomes included changes waist circumference, weight, blood glucose, lipid levels, pressure, quality life, dampness scale scores. Feasibility assessed by adherence required intervention, adverse events recorded throughout Compared group, exhibited reduction BMI (mean ± SD: -0.54 1.67 vs. -0.13 0.81), diastolic fasting triglyceride levels though this difference not statistically significant. However, demonstrated significant improvements several parameters, including fatigue scale-14 (FS-14), general anxiety disorder (GAD-7), patient questionnaire-9 items (PHQ-9), Pittsburgh sleep (PSQI), Adherence high, 82% (41/50) completing trial, no serious reported. adults have been demonstrated, highlighting its potential multifaceted benefits high adherence. https://www.chictr.org.cn, identifier ChiCTR2300072981.

Язык: Английский

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Association of the platelet-to-high-density lipoprotein cholesterol ratio (PHR) with metabolic syndrome and metabolic overweight/obesity phenotypes: A study based on the Dryad database

PLoS ONE, Год журнала: 2025, Номер 20(5), С. e0321625 - e0321625

Опубликована: Май 6, 2025

Background Overweight/obesity and metabolic syndrome (MetS) are major global public health challenges. The platelet-to-high-density lipoprotein cholesterol ratio (PHR) has emerged as a potential biomarker reflecting both inflammatory status lipid metabolism; however, its association with MetS overweight/obesity phenotypes is not well understood. present study aims to investigate the of PHR phenotypes. Methods We derived data from Dryad repository. This retrospective included 1,592 physical examination participants in Wuhan Union Hospital 2020 2021. Based on BMI categories status, we defined distinguished four phenotypes: metabolically healthy normal weight (MHNW), unhealthy (MUNW), (MHO), (MUO). was calculated platelets HDL cholesterol. Logistic regression analysis used test independent between In addition, performed smooth curve fitting subgroup analyses. Results analysis, after adjusting for covariates, indicated that each 10-unit increase associated elevated risks (OR = 1.29, 95% CI: 1.24–1.35). There significant positive occurrence MHO 1.15, 1.11–1.19) MUO 1.16, 1.12–1.20), while MUNW remained unclear ( P 0.73). found nonlinear relationship incidence MetS, MHO, MUO. Conclusion demonstrates strong associations MUO, indicating utility an early dysfunction.

Язык: Английский

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One-year metreleptin in Colombian sisters with congenital leptin deficiency

Adipocyte, Год журнала: 2025, Номер 14(1)

Опубликована: Май 26, 2025

We discovered two adult sisters in Colombia, lineally consanguineous, with severe obesity and undetectable serum leptin levels despite markedly elevated body fat. Their clinical profile included childhood-onset extreme weight gain, intense hunger, hyperphagia, hypogonadotropic hypogonadism, family history of obesity. Direct sequencing the LEP gene revealed a novel homozygous missense mutation exon 3 (c.350G>T [p.C117F]). The presence this mutation, leptin, confirmed diagnosis monogenic deficiency. Here we describe outcomes 12-month treatment recombinant human (metreleptin). Metabolic endocrine assessments were conducted before after therapy. Metreleptin therapy significantly reduced BMI: from 59 to 38 kg/m2 (OBX1, age 27) 60 48 (OBX2, 24). Total fat mass decreased, lipids normalized, insulin sensitivity improved. Hypogonadotropic hypogonadism reversed, menstruation resumed. Thus, metreleptin reversed major metabolic abnormalities associated deficiency these sisters. Limitations include small sample size, absence control group, lack anti-metreleptin antibody measurements. Nevertheless, our findings support that replacement is currently only effective hormonal for form

Язык: Английский

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