Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 1211 - 1225
Опубликована: Фев. 1, 2024
Objective:
To
evaluate
the
prognostic
value
of
systemic
immune-inflammatory
index
(SII)
for
predicting
in-hospital
major
adverse
cardiovascular
events
(MACEs)
in
patients
with
acute
myocardial
infarction
(AMI)
and
establish
a
relevant
nomogram.
Methods:
This
study
included
954
AMI
patients.
We
examined
three
inflammatory
factors
(SII,
platelet
to
lymphocyte
ratio
(PLR)
neutrophil
(NLR))
see
which
one
predicts
MACEs
better.
The
predictors
were
subsequently
screened
using
bidirectional
stepwise
regression
method,
MACE
nomogram
was
constructed
via
logistic
analysis.
predictive
model
evaluated
area
under
curve
(AUC),
sensitivity
specificity.
In
addition,
clinical
utility
decision
also
compared
Global
Registry
Acute
Coronary
Events
(GRACE)
scoring
system.
Results:
334
(35.0%)
had
MACEs.
SII
(AUC
=0.684)
greater
than
PLR
=0.597,
P<
0.001)
or
NLR
(AUC=0.654,
P=0.01).
(AUC)
SII-based
multivariable
MACEs,
based
on
SII,
Killip
classification,
left
ventricular
ejection
fraction,
age,
urea
nitrogen
(BUN)
concentration
electrocardiogram-based
diagnosis,
0.862
(95%
CI:
0.833–
0.891).
Decision
calibration
analysis
revealed
that
demonstrated
good
fit
provided
positive
net
benefits
without
SII.
GRACE
system
(P<
0.001).
Conclusion:
is
promising,
reliable
biomarker
identifying
at
high
risk
may
serve
as
quick
easy
tool
identify
these
Keywords:
index,
events,
inflammation,
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(15), С. 4405 - 4405
Опубликована: Июль 28, 2022
Endothelial
dysfunction
is
one
of
the
earliest
manifestations
atherosclerosis,
contributing
to
its
development
and
progression.
Mental
stress
induces
endothelial
through
increased
activity
sympathetic
nervous
system,
release
corticotropin-releasing
hormone
from
hypothalamus,
inhibition
nitric
oxide
(NO)
synthesis
by
cortisol,
levels
pro-inflammatory
cytokines.
Mental-stress-induced
output
system
concomitant
withdrawal
parasympathetic
inflammatory
reflex
results
in
systemic
inflammation
activation
a
neural–hematopoietic–arterial
axis.
This
includes
brainstem
subcortical
regions
network,
bone
marrow
activation,
leukocytes
into
circulation
their
migration
arterial
wall
atherosclerotic
plaques.
Low-grade,
sterile
involved
all
steps
atherogenesis,
coronary
plaque
formation
destabilisation
rupture.
Increased
tone
may
cause
smooth-muscle-cell
proliferation,
resulting
vascular
hypertrophy,
thus
hypertension.
Emotional
events
also
instability
cardiac
repolarisation
due
brain
lateralised
imbalance
autonomic
stimulation,
which
lead
asymmetric
arrhythmia.
Acute
emotional
can
provoke
severe
catecholamine
release,
leading
direct
myocyte
injury
calcium
overload,
known
as
myocytolysis,
microvascular
vasoconstriction,
an
increase
left
ventricular
afterload.
These
changes
trigger
heart
failure
syndrome
mimicking
acute
myocardial
infarction,
characterised
transient
apical
ballooning,
(Takotsubo)
cardiomyopathy.
Women
are
more
prone
than
men
develop
mental-stress-induced
ischemia
(MSIMI),
probably
reflecting
gender
differences
patterns
during
mental
stress.
Although
guidelines
on
CV
prevention
recognise
psychosocial
factors
risk
modifiers
improve
prediction
decision
making,
evidence
that
assessment
treatment
will
prevent
CAD
needs
further
evaluation.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 18, 2023
Glucocorticoids
are
steroid
hormones
that
regulate
a
host
of
cellular
and
physiological
functions.
However,
they
arguably
best
known
for
their
potent
anti-inflammatory
properties.
Chronic
inflammation
is
well-known
to
promote
the
development
progression
numerous
types
cancer,
emerging
evidence
suggests
glucocorticoid
regulation
affects
cancer
development.
timing,
intensity,
duration
signaling
have
important
but
often
contradictory
effects
on
Moreover,
glucocorticoids
widely
used
in
parallel
with
radiation
chemotherapy
control
pain,
dyspnea,
swelling,
use
may
compromise
anti-tumor
immunity.
This
review
will
explore
particular
focus
pro
Atherosclerosis,
Год журнала:
2024,
Номер
395, С. 117577 - 117577
Опубликована: Май 10, 2024
A
sedentary
lifestyle,
low
levels
of
physical
activity
and
fitness,
poor
dietary
patterns,
psychosocial
stress
are
strongly
associated
with
increased
morbidity
mortality
from
atherosclerotic
cardiovascular
disease
(ASCVD).
Conversely,
engaging
in
regular
activity,
maintaining
optimal
fitness
levels,
adhering
to
a
heart-healthy
pattern,
effectively
managing
body
weight,
ensuring
adequate
sleep,
implementing
stress-reduction
strategies,
addressing
risk
factors
reduced
ASCVD.
This
comprehensive
review
synthesizes
current
evidence
large
observational
studies
randomized
controlled
trials
on
lifestyle
as
determinants
ASCVD
health.
It
also
briefly
reviews
mechanistic
insights
into
how
such
shear
stress,
reactive
oxygen
species
production,
chronic
inflammation,
platelets
coagulation
activation,
endothelial
dysfunction,
sympathetic
hyperactivity
contribute
the
initiation
exacerbation
factors.
These
include
obesity,
hyperglycemia,
type
2
diabetes,
hypertension,
dyslipidemia,
subsequently
leading
development
progression
atherosclerosis,
ultimately
resulting
or
acute
events.
To
bridge
translational
gap
between
epidemiologic
trial-based
clinical
practice,
practical
recommendations
summarized
facilitate
translation
scientific
knowledge
actionable
interventions
promote
Acknowledged
is
evidence-based
adoption
within
healthcare
systems,
which
remains
crucial
objective
advancing
health
at
population
level.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
The
Visceral
Adiposity
Index
(VAI)
is
a
straightforward
and
gender-specific
marker
that
combines
anthropometric
measurements
with
lipid
profiles.
objective
of
this
study
was
to
evaluate
the
relationship
between
VAI
coronary
heart
disease
(CHD).
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 1211 - 1225
Опубликована: Фев. 1, 2024
Objective:
To
evaluate
the
prognostic
value
of
systemic
immune-inflammatory
index
(SII)
for
predicting
in-hospital
major
adverse
cardiovascular
events
(MACEs)
in
patients
with
acute
myocardial
infarction
(AMI)
and
establish
a
relevant
nomogram.
Methods:
This
study
included
954
AMI
patients.
We
examined
three
inflammatory
factors
(SII,
platelet
to
lymphocyte
ratio
(PLR)
neutrophil
(NLR))
see
which
one
predicts
MACEs
better.
The
predictors
were
subsequently
screened
using
bidirectional
stepwise
regression
method,
MACE
nomogram
was
constructed
via
logistic
analysis.
predictive
model
evaluated
area
under
curve
(AUC),
sensitivity
specificity.
In
addition,
clinical
utility
decision
also
compared
Global
Registry
Acute
Coronary
Events
(GRACE)
scoring
system.
Results:
334
(35.0%)
had
MACEs.
SII
(AUC
=0.684)
greater
than
PLR
=0.597,
P<
0.001)
or
NLR
(AUC=0.654,
P=0.01).
(AUC)
SII-based
multivariable
MACEs,
based
on
SII,
Killip
classification,
left
ventricular
ejection
fraction,
age,
urea
nitrogen
(BUN)
concentration
electrocardiogram-based
diagnosis,
0.862
(95%
CI:
0.833–
0.891).
Decision
calibration
analysis
revealed
that
demonstrated
good
fit
provided
positive
net
benefits
without
SII.
GRACE
system
(P<
0.001).
Conclusion:
is
promising,
reliable
biomarker
identifying
at
high
risk
may
serve
as
quick
easy
tool
identify
these
Keywords:
index,
events,
inflammation,
