Evaluation of bi-directional causal association between obstructive sleep apnoea syndrome and diabetic microangiopathy: a Mendelian randomization study DOI Creative Commons
Qianqian Liu,

Xingyu Chang,

Rongna Lian

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Май 9, 2024

Background The relationship between obstructive sleep apnea syndrome (OSAS) and diabetic microangiopathy remains controversial. Objective This study aimed to use bidirectional two-sample Mendelian Randomization (MR) assess the causal OSAS microangiopathy. Methods First, we used Linkage Disequilibrium Score Regression(LDSC) analysis genetic correlation. Then, MR was conducted in two stages: lung function-related indicators (forced vital capacity (FVC) forced expiratory volume 1 s (FEV1)) were investigated as exposures, with outcome first stage, tools proxy variables for measures second step. Genome-wide association data came from open GWAS database. We Inverse-Variance Weighted (IVW), MR-Egger regression, median, Simple mode, mode effect estimation pleiotropy testing. also performed sensitivity analyses test robustness of results. Furthermore, multivariate mediation analyses. Results In LDSC analysis, found a correlation OSAS, FVC, FEV 1, based on IVW genetically predicted positively correlated incidence retinopathy (DR), kidney disease (DKD), neuropathy (DN). subgroup DR, there significant background (BDR) proliferative (PDR). reverse did not show OSAS. Reduced FVC had potential increased DR PDR. FEV1 BDR, PDR, DKD. Multivariate showed that remained after adjusting confounding factors. However, find mediating Conclusion Our results suggest may be cause development microangiopathy, associated high risk providing reference better understanding prevention

Язык: Английский

Craniofacial, Dental, and Upper Airway Morphologic features of Severely Obese Adults with Obstructive Sleep Apnea DOI
Liang Xia, Wenxin Jiang, Kan Yao

и другие.

International Dental Journal, Год журнала: 2025, Номер 75(3), С. 1736 - 1744

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Depressive symptoms mediate the association between sleep disorders and gallstone disease: a causal mediation analysis of NHANES 2017–2020 DOI Creative Commons

Yisen Hou,

Rui Li,

Zhen Xu

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

Gallstones are a prevalent digestive system disorder with significant health implications. Recent research suggests that sleep disorders, such as insomnia and obstructive apnea hypopnea syndrome, may influence the development of gallstones through various metabolic pathways. Depression, often accompanying play mediating role in this relationship. This study uses data from 2017-2020 National Health Nutrition Examination Survey (NHANES) to explore potential depression association between disorders gallstones. We analyzed 7,868 adults aged 20 older NHANES 2017-2020. were defined based on self-reported medical diagnoses. Sleep assessed difficulties, depressive symptoms measured using Patient Questionnaire-9 (PHQ-9) scale. Logistic regression models evaluated direct associations symptoms, Causal mediation analysis further examined symptoms. Finally, subgroup analyses performed by age, sex, obesity status. Both (OR = 2.00; 95% CI, 1.73-2.32; P<0.001) 2.09; 1.70-2.56; significantly associated gallstones, results remaining after adjusting for confounders. A was also observed 5.53; 4.71-6.50; P<0.001). Mediation indicated partially mediate relationship an average causal effect (ACME) 0.00720 (95% 0.00299-0.01220; (ADE) 0.0305 0.0129-0.0488; Depression mediates 18.89% 0.0704-0.4096; Subgroup showed individuals 40-59, males, both obese non-obese groups (all P<0.05), although no found females (P>0.05). demonstrates playing partial role. Improving help reduce risk disorders.

Язык: Английский

Процитировано

0
Knowledge, attitudes, and practices of physicians regarding multidisciplinary treatment of obstructive sleep apnea: a cross-sectional study DOI Creative Commons

P. Shen

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 23, 2025

To investigate physicians' knowledge, attitudes, and practices (KAP) regarding the multidisciplinary treatment of Obstructive Sleep Apnea (OSA). A multicenter cross-sectional study was conducted in May 2024, enrolling physicians from southwestern China. The collected demographic data assessed KAP through self-administered questionnaires, with respiratory otolaryngology departments defined as relevant departments. total 329 valid questionnaires were collected. Of these respondents, 173 (52.6%) female, 114 (34.7%) had participated OSA-related training. mean scores for knowledge attitudes 24.61 ± 8.27 (possible range: 0-34) 39.99 4.34 10-50), respectively. Practice directly indirectly involved OSA averaged 24.28 4.70 21.28 4.24 6-30), Structural equation modeling results indicated that related to OSA, a significant positive effect on both (β = 5.53, P < 0.001) 5.8, 0.001). For 5.41, Physicians showed adequate toward treatment; targeted education is recommended enhance consistency across

Язык: Английский

Процитировано

0
Therapeutic potential of GLP-1RAs in sleep apnea with genetic associations to type 2 diabetes DOI Creative Commons
Fang Cheng, Kang Yang,

Yaoling Wang

и другие.

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 28, 2025

Some observational studies found that there is an epidemiological association between type 2 diabetes (T2D) and sleep apnea (SA) glucose-lowering drugs may lower SA risk. However, the causative relationship among them remains unclear. Linkage Disequilibrium Score Regression (LDSC) was utilized to assess genetic correlation T2D SA. Mendelian Randomization (MR) applied, primarily using inverse variance weighted (IVW) method, evaluate causal Additionally, we performed Drug-target MR analysis impact of Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) on We used two kinds instruments proxy exposure GLP-1RAs, including expression quantitative trait loci target genes, variants within genes associated with glycated hemoglobin A1c(HbA1c) from genome wide study. Summary-data-based (SMR) IVW were calculate effect estimates. A two-step further employed explore potential mediating factors in T2D-SA relationship. bidirectional GLP-1RAs-mediated reductions HbA1c levels showed associations decreased risk independent datasets: (odds ratio (OR)1 = 0.48 [95% confidence interval (CI) 0.28-0.83], P1 9.21 × 10-3; OR2 0.21 CI 0.05-0.92], P2 3.89 10-2); a higher GLP-1R (OR1 0.98 0.96-1.00], 4.55 10-2; 0.95 0.92-0.99], 1.71 10-2). Body mass index (BMI) current tobacco smoking mediated 20.28% 6.65%, respectively, total GLP-1RAs This study suggested SA, GLP-1-RAs potentially serving as therapeutic for The reduction by be partially decreases BMI smoking.

Язык: Английский

Процитировано

0
Association of Weight Change Across Adulthood with Obstructive Sleep Apnea: The Multi-Ethnic Study of Atherosclerosis DOI Creative Commons
Jiaqi Du,

Wenlong Zhao,

Yixiang Liu

и другие.

Nature and Science of Sleep, Год журнала: 2025, Номер Volume 17, С. 1191 - 1204

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0
The association of objective daytime sleepiness with impaired glucose metabolism in patients with obstructive sleep apnea: a multi-omics study DOI
Le Chen, Baixin Chen,

Yanyuan Dai

и другие.

SLEEP, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 16, 2024

Abstract Study Objectives To examine the joint effect of obstructive sleep apnea (OSA) and objective excessive daytime sleepiness (EDS) on glucose metabolism underlying mechanisms. Methods We included 127 patients with OSA. The multiple latency test (MSLT) Epworth scale (ESS) were used to assess subjective EDS, respectively. Disordered was defined as either a physician diagnosis or having fasting blood levels ≥5.6 mmol/L. Values insulin homeostasis model assessment resistance (HOMA-IR) higher than median values our sample high resistance. Serum metabolomics fecal microbiota explore Results Lower MSLT associated glucose, insulin, HOMA-IR. Furthermore, EDS increased odds disordered metabolism, elevated Dysregulation serum valine degradation dysbiosis Bacteroides thetaiotaomicron impaired in OSA EDS. No association between observed. Conclusions objective, but not subjective, is an risk B. appear link

Язык: Английский

Процитировано

2
Pharmacologic Treatment of Obesity in adults and its impact on comorbidities: 2024 Update and Position Statement of Specialists from the Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso) and the Brazilian Society of Endocrinology and Metabolism (SBEM) DOI Creative Commons
Rodrigo O. Moreira, Cynthia Melissa Valério, Alexandre Hohl

и другие.

Archives of Endocrinology and Metabolism, Год журнала: 2024, Номер 68

Опубликована: Янв. 1, 2024

Pharmacological treatment of obesity is passing through many changes in the last decades; different agents have been approved, and newer options are leaning towards higher efficacy a more favourable safety profile; however, medications approved for longer time still available useful patients. This document an 2024 Update Position Statement Specialists from Brazilian Association Study Obesity Metabolic Syndrome (Abeso) Society Endocrinology Metabolism (SBEM), with aim reviewing all management Brazil (sibutramine, orlistat, liraglutide, semaglutide bupropion/naltrexone fixed dose), addition tirzepatide, that other countries likely soon Brazil. The review focused on efficacy, profile impact drugs (based existing studies) comorbidities.

Язык: Английский

Процитировано

2
The Impact of Obesity on Cardiorespiratory Fitness and Weight Changes in a Cardiac Rehabilitation Program DOI

Nikita Mittal,

C. Sonners,

Janna Raphelson

и другие.

Journal of Cardiopulmonary Rehabilitation and Prevention, Год журнала: 2024, Номер unknown

Опубликована: Июнь 5, 2024

Mittal, Nikita MD; Sonners, Christine Raphelson, Janna Sykes, Alex Roberts, Erin Swiatkiewicz, Iwona Taub, Pam R Malhotra, Atul Schmickl, Christopher N MD, PhD Author Information

Язык: Английский

Процитировано

1
Screening of preoperative obstructive sleep apnea by cardiopulmonary coupling and its risk factors in patients with plans to receive surgery under general anesthesia: a cross-sectional study DOI Creative Commons

Shujie Hou,

Guojia Zhu,

Xu Liu

и другие.

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Июль 24, 2024

Preoperative obstructive sleep apnea (OSA) is supposed to be the abnormally high occurrence of OSA night before surgery under general anesthesia. This study aimed evaluate prevalence preoperative using cardiopulmonary coupling (CPC) and its correlation with imbalance sympathetic/parasympathetic nervous system.

Язык: Английский

Процитировано

1
Chronic intermittent hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production DOI Creative Commons
Alyssa Huff, Marlusa Karlen‐Amarante, Luíz M. Oliveira

и другие.

eLife, Год журнала: 2023, Номер 12

Опубликована: Ноя. 9, 2023

Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder that results in multiple bouts of intermittent hypoxia. OSA has many neurological and systemic comorbidities, including dysphagia, or disordered swallow, discoordination with breathing. However, the mechanism which chronic hypoxia (CIH) causes dysphagia unknown. Recently, we showed postinspiratory complex (PiCo) acts as an interface between swallow pattern generator (SPG) inspiratory rhythm generator, preBötzinger complex, to regulate proper swallow-breathing coordination (Huff et al., 2023). PiCo characterized by interneurons co-expressing transporters for glutamate (Vglut2) acetylcholine (ChAT). Here show optogenetic stimulation ChATcre:Ai32, Vglut2cre:Ai32, ChATcre:Vglut2FlpO:ChR2 mice exposed CIH does not alter coordination, but unexpectedly disrupts behavior via triggering variable motor patterns. This suggests glutamatergic-cholinergic neurons are only critical regulation also play important role modulation patterning. Our study disruption, seen OSA, involves central nervous mechanisms interfering patterning laryngeal activation. These findings crucial understanding underlying both other disorders.

Язык: Английский

Процитировано

3