Asian Journal of Pharmaceutical Research and Health Care,
Год журнала:
2024,
Номер
16(4), С. 344 - 351
Опубликована: Окт. 1, 2024
A
BSTRACT
Even
with
the
swift
progress
in
scientific
understanding
of
various
diseases
such
as
cancer,
cardiovascular
diseases,
and
diabetes,
there
remains
a
need
for
effective
new
treatments.
Now,
other
drug
development
strategies,
repurposing
existing
medicines
to
treat
which
will
save
time
money,
are
being
investigated.
Since
metformin
is
one
most
used
drugs
worldwide
it
investigated
uses,
therefore,
this
review
potential
uses
beyond
its
established
use
diabetes
highlighted
several
polycystic
ovary
syndrome
(PCOS),
weight
reduction,
lowering
plasma
lipids,
delaying
aging
process,
possible
role
reducing
mortality
pandemic
COVID-19.
An
extensive
literature
search
was
conducted
on
PubMed
Google
Scholar
databases
identify
relevant
literature.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 23, 2024
Protein
post-translational
modifications
(PTMs)
represent
a
crucial
aspect
of
cellular
regulation,
occurring
after
protein
synthesis
from
mRNA.
These
modifications,
which
include
phosphorylation,
ubiquitination,
acetylation,
methylation,
glycosylation,
Sumoylation,
and
palmitoylation,
play
pivotal
roles
in
modulating
function.
PTMs
influence
localization,
stability,
interactions,
thereby
orchestrating
variety
processes
response
to
internal
external
stimuli.
Dysregulation
is
linked
spectrum
diseases,
such
as
cancer,
inflammatory
neurodegenerative
disorders.
UFMylation,
type
PTMs,
has
recently
gained
prominence
for
its
regulatory
role
numerous
processes,
including
stress,
key
signaling
pathways
influencing
functions.
This
review
highlights
the
function
UFMylation
development
progression
tumors,
underscoring
potential
therapeutic
target.
Moreover,
we
discuss
tumorigenesis
malignant
progression,
explore
impact
on
cancer
immunotherapy.
The
article
aims
provide
comprehensive
overview
biological
functions
propose
how
targeting
could
enhance
effectiveness
immunotherapy
strategies.
Asian Journal of Pharmaceutical Research and Health Care,
Год журнала:
2024,
Номер
16(4), С. 344 - 351
Опубликована: Окт. 1, 2024
A
BSTRACT
Even
with
the
swift
progress
in
scientific
understanding
of
various
diseases
such
as
cancer,
cardiovascular
diseases,
and
diabetes,
there
remains
a
need
for
effective
new
treatments.
Now,
other
drug
development
strategies,
repurposing
existing
medicines
to
treat
which
will
save
time
money,
are
being
investigated.
Since
metformin
is
one
most
used
drugs
worldwide
it
investigated
uses,
therefore,
this
review
potential
uses
beyond
its
established
use
diabetes
highlighted
several
polycystic
ovary
syndrome
(PCOS),
weight
reduction,
lowering
plasma
lipids,
delaying
aging
process,
possible
role
reducing
mortality
pandemic
COVID-19.
An
extensive
literature
search
was
conducted
on
PubMed
Google
Scholar
databases
identify
relevant
literature.
