ABSTRACT
This
comprehensive
investigation
delves
into
the
interconnectedness
of
different
features
cardiometabolic
syndrome,
such
as
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD),
atherosclerotic
cardiovascular
(ASCVD),
and
gut
dysbiosis,
highlighting
crucial
role
nutraceuticals
in
their
management
prevention.
Given
significant
overlap
pathophysiology
these
conditions,
treatment
with
nutraceuticals,
especially
those
derived
from
agro‐food
waste,
offers
a
promising,
sustainable,
innovative
approach
to
healthcare.
The
2030
Agenda
for
Sustainable
Development
One
Health
concept
are
key
frameworks
selecting
most
interesting
supply
chain
production
ensuring
environmental
sustainability,
agricultural
practices.
In
this
review,
therapeutic
potential
kiwifruit
apples
has
been
explored,
detailing
how
bioactive
compounds,
like
polyphenols,
fiber,
pectin,
kaempferol,
phloretin,
phlorizin,
may
contribute
MASLD,
ASCVD,
dysbiosis.
Various
extraction
methods
active
ingredients,
including
chemical,
water,
enzyme
extractions,
analyzed
respective
benefits
drawbacks.
By
integrating
scientific
research,
sustainable
practices,
methods,
we
can
develop
effective
strategies
combat
pervasive
health
issues.
holistic
not
only
enhances
individual
outcomes
but
also
supports
broader
societal
goals,
promoting
healthier
future
all.
Non-alcoholic
fatty
liver
disease
(NAFLD)
has
become
the
leading
cause
of
chronic
diseases,
affecting
approximately
30%
global
adult
population,
with
a
rise
largely
attributed
to
increasing
rates
obesity
and
diabetes
worldwide.
Historically,
term
“NAFLD”
did
not
explicitly
link
condition
its
most
common
causes,
such
as
diabetes,
or
principal
pathophysiological
mechanisms,
including
insulin
resistance
low-grade
metabolic
inflammation.
This
semantic
laxity
potentially
reduced
attempts
at
screening,
diagnosis,
management.
The
shift
using
terms
metabolic-associated
(MAFLD)
dysfunction-associated
steatotic
(MASLD)
reflects
more
accurate
understanding
condition’s
origins
highlights
broader
implications,
particularly
cardiovascular
diseases.
MAFLD/MASLD
represents
convergence
point
between
hepatology
cardiology,
dysfunction
serving
bridge
pathology
increased
risk.
Growing
clinical
evidence
reveals
strong
association
morbidity
mortality.
Despite
this,
risks
associated
are
often
underestimated,
especially
among
cardiologists.
narrative
review
explores
potential
implications
for
cardiology
practice,
examining
diagnostic
criteria,
risk
assessment,
adjustments
in
collaborative
care
strategies,
treatment
options,
directions
future
research.
ABSTRACT
This
comprehensive
investigation
delves
into
the
interconnectedness
of
different
features
cardiometabolic
syndrome,
such
as
metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD),
atherosclerotic
cardiovascular
(ASCVD),
and
gut
dysbiosis,
highlighting
crucial
role
nutraceuticals
in
their
management
prevention.
Given
significant
overlap
pathophysiology
these
conditions,
treatment
with
nutraceuticals,
especially
those
derived
from
agro‐food
waste,
offers
a
promising,
sustainable,
innovative
approach
to
healthcare.
The
2030
Agenda
for
Sustainable
Development
One
Health
concept
are
key
frameworks
selecting
most
interesting
supply
chain
production
ensuring
environmental
sustainability,
agricultural
practices.
In
this
review,
therapeutic
potential
kiwifruit
apples
has
been
explored,
detailing
how
bioactive
compounds,
like
polyphenols,
fiber,
pectin,
kaempferol,
phloretin,
phlorizin,
may
contribute
MASLD,
ASCVD,
dysbiosis.
Various
extraction
methods
active
ingredients,
including
chemical,
water,
enzyme
extractions,
analyzed
respective
benefits
drawbacks.
By
integrating
scientific
research,
sustainable
practices,
methods,
we
can
develop
effective
strategies
combat
pervasive
health
issues.
holistic
not
only
enhances
individual
outcomes
but
also
supports
broader
societal
goals,
promoting
healthier
future
all.
