Esculapio,
Год журнала:
2023,
Номер
19(1), С. 29 - 33
Опубликована: Май 13, 2023
Objective:
To
determine
the
correlation
between
visceral
fat
and
body
mass
index
(BMI),
waist
circumference
(WC),
waist-to-hip
ratio
(WHR),
CVD
risk
factors
in
males
females
of
Pakistani
population.
Methods
Four
hundred
six
(406)
participants
were
enrolled
study
after
taking
ethical
approval
from
institute.
The
age
was
30
to
65
years.
A
uniform
survey
physical
examination
given
each
participant.
We
took
anthropometric
measurements
(BMI,
WC,
WHR,
WHtR,
SBP,
DBP).
Fasting
blood
sugar
serum
lipid
profile
(TC,
TG,
HDL-C,
LDL-C)
measured.
Results:
with
≥10%
have
increased
levels
DBP,
Cholesterol,
LDL,
FBS.
significant
positive
observed
Weight,
BMI,
Conclusion:
CV
increases
increase
weight,
FBS
Healthcare,
Год журнала:
2022,
Номер
10(9), С. 1616 - 1616
Опубликована: Авг. 25, 2022
Obesity
is
a
chronic
disease
characterized
by
the
abnormal
or
excessive
accumulation
of
body
fat,
affecting
more
than
1
billion
people
worldwide.
commonly
associated
with
other
metabolic
disorders,
such
as
type
2
diabetes,
non-alcoholic
fatty
liver
disease,
cardiovascular
diseases,
kidney
and
cancers.
Factors
sedentary
lifestyle,
overnutrition,
socioeconomic
status,
environmental
genetic
conditions
can
cause
obesity.
Many
molecules
signaling
pathways
are
involved
in
pathogenesis
obesity,
nuclear
factor
(NF)-κB,
Toll-like
receptors
(TLRs),
adhesion
molecules,
G
protein-coupled
(GPCRs),
programmed
cell
death
(PD-1)/programmed
death-ligand
(PD-L1),
sirtuin
(SIRT1).
Commonly
used
strategies
obesity
management
treatment
include
exercise
dietary
change
restriction
for
early
stage
bariatric
surgery
server
Food
Drug
Administration
(FDA)-approved
medicines
semaglutide
liraglutide
that
be
monotherapy
synergistic
treatment.
In
addition,
psychological
management,
especially
patients
distress,
good
option.
Gut
microbiota
plays
an
important
role
its
comorbidities,
gut
microbial
reprogramming
fecal
transplantation
(FMT),
probiotics,
prebiotics,
synbiotics
shows
promising
potential
syndrome.
clinical
trials
ongoing
to
evaluate
therapeutic
effects
different
treatments.
Currently,
prevention
best
options
prevent
progression
many
comorbidities.
Communications Biology,
Год журнала:
2023,
Номер
6(1)
Опубликована: Сен. 1, 2023
Abstract
Genome-wide
association
study
has
identified
fruitful
variants
impacting
heritable
traits.
Nevertheless,
identifying
critical
genes
underlying
those
significant
been
a
great
task.
Transcriptome-wide
(TWAS)
is
an
instrumental
post-analysis
to
detect
gene-trait
associations
focusing
on
modeling
transcription-level
regulations,
which
made
numerous
progresses
in
recent
years.
Leveraging
from
expression
quantitative
loci
(eQTL)
regulation
information,
TWAS
advantages
detecting
functioning
regulated
by
disease-associated
variants,
thus
providing
insight
into
mechanisms
of
diseases
and
other
phenotypes.
Considering
its
vast
potential,
this
review
article
comprehensively
summarizes
TWAS,
including
the
methodology,
applications
available
resources.
Journal of Clinical Hypertension,
Год журнала:
2024,
Номер
26(10), С. 1145 - 1154
Опубликована: Авг. 19, 2024
Cardiovascular
disease
(CVD)
is
a
leading
cause
of
death
worldwide,
and
several
studies
have
attempted
to
identify
its
risk
factors.
This
study
aimed
investigate
the
association
between
sleep
duration
quality,
7-year
incidence
CVD
among
middle-aged
older
Chinese
individuals.
A
total
6682
participants
aged
45-90
years
from
China
Health
Retirement
Longitudinal
Study
database
were
included
in
this
study.
The
authors
estimated
quality
based
on
self-reported
data
night
hours
disturbance
symptoms,
examined
associations
them
composite
outcome
using
logistic
regression
models.
1692
(25.32%)
reported
new
events
during
follow-up.
Short
(<
6
h/night)
was
significantly
associated
with
higher
all
three
models
(p
<
.05).
However,
not
observed
for
long
(>
8
h/night).
Additionally,
mild
models,
severe
Models
2
3
had
After
stratification
by
age
daytime
napping,
we
still
found
significant
short
individuals
45-59
years,
non-nappers
these
≥60
or
nappers
>
In
conclusion,
are
both
an
increased
American Journal of Translational Research,
Год журнала:
2025,
Номер
17(2), С. 1170 - 1177
Опубликована: Янв. 1, 2025
The
neutrophil
to
lymphocyte
ratio
(NLR)
is
a
simple,
reliable,
and
easily
accessible
composite
index
that
has
garnered
increasing
attention
in
cardiovascular
research.
NLR
closely
associated
with
the
onset,
progression,
prognosis
of
various
diseases.
This
article
reviews
etiological
prognostic
roles
conditions
such
as
coronary
atherosclerotic
heart
disease,
hypertension,
arrhythmia,
failure,
valvular
disease.
Studies
have
shown
involved
pathophysiologic
processes
these
diseases
holds
significant
predictive
value
for
their
prognosis.
Additionally,
compared
other
inflammatory
markers,
offers
advantages
low
cost,
repeatability,
ability
be
measured
at
community-level
primary
healthcare
settings,
thus
providing
new
insight
prediction
like
artery
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Июнь 3, 2025
The
correlation
between
body
mass
index
(BMI)
and
the
outcomes
for
patients
receiving
surgical
intervention
abdominal
aortic
aneurysm
(AAA)
is
still
debated.
Consequently,
this
study
seeks
to
investigate
association
BMI
mortality
following
elective
open
repair
(EOAR).
This
involves
a
secondary
analysis
derived
from
data
collected
in
prospective
cohort
framework.
It
focuses
on
individuals
who
received
EOAR
across
ten
vascular
surgery
centers
Denmark
January
1,
2000,
December
31,
2014.
employed
Cox
proportional
hazards
regression
model
examine
connection
EOAR.
To
detect
any
potential
nonlinear
associations,
with
cubic
spline
functions
smooth
curve
fitting
was
utilized.
Furthermore,
we
performed
numerous
sensitivity
subgroup
evaluations
ensure
reliability
of
our
results.
Upon
controlling
confounding
variables,
demonstrated
clear
inverse
Specifically,
each
1
kg/m²
increase
corresponded
2.7%
reduction
risk
(HR
=
0.973;
95%
CI:
0.958-0.988).
Compared
normal
weight,
those
classified
as
underweight
faced
62.6%
higher
1.626;
1.142-2.314),
whereas
overweight
obese
experienced
by
18.2%
0.818;
0.722-0.928)
15.8%
0.842;
0.721-0.998),
respectively.
Additionally,
identified
relationship
postoperative
mortality,
critical
point
at
25.78
kg/m².
Below
inflection
point,
decrease
significantly
increased
8%
0.920;
0.893-0.949).
Beyond
further
increases
did
not
impact
risk.
In
undergoing
EOAR,
an
negatively
associated
mortality.
specific
exists
Clinicians
should
carefully
weigh
risks
under
consider
delaying
enhance
nutrition.
contrast,
or
may
require
pre-surgery
weight
management.
Heliyon,
Год журнала:
2023,
Номер
9(3), С. e14028 - e14028
Опубликована: Фев. 25, 2023
Artemisinin
derivatives
have
been
found
to
anti-obesity
effects
recently,
but
the
mechanism
is
still
controversial.
Herein,
long-term
DHA
treatment
in
obese
mice
significantly
reduced
body
weight
and
improved
glucose
metabolism.
However,
short-term
did
not
affect
metabolism
mice,
suggesting
that
with
could
be
secondary
reduction.
Consistent
previous
reports,
we
observed
inhibited
differentiation
of
adipocytes.
Mechanistically,
expression
NADPH
oxidase
4
(NOX4)
white
adipose
tissue
(WAT)
differentiated
adipocytes,
using
NOX4
siRNA
or
inhibitor
GKT137831
attenuated
adipocyte
differentiation.
Over-expression
partially
reversed
inhibition
effect
on
adipogenic
preadipocytes.
In
addition,
targeted
proteomics
analysis
showed
abnormality
metabolic
pathways.
conclusion,
fat
mass
possibly
by
inhibiting
suppress
lipid
accumulation
European Heart Journal - Quality of Care and Clinical Outcomes,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 11, 2024
Abstract
Aims
The
relationship
between
the
level
of
baseline
risk
factor
control
and
cardiovascular
outcomes
in
hypertensive
patients
with
blood
pressure
interventions
is
not
well
understood.
It
also
unclear
whether
persuasively
associated
a
lowering
strategy.
Method
results
We
performed
an
analysis
Strategy
Blood
Pressure
Intervention
Elderly
Hypertensive
Patients
(STEP)
trial.
Participants
without
complete
data
were
excluded.
primary
outcome
was
composite
events
all-cause
mortality.
Cox
proportional
hazard
models
used
to
calculate
ratio
(HR)
estimate
association
levels
(≥6,
5,
4,
≤3)
outcomes.
A
total
8337
participants
involved
analysis,
median
follow-up
period
3.19
years.
Each
additional
uncontrolled
24%
higher
(HR
1.24,
95%
CI
1.11–1.37).
Compared
optimal
control,
those
≤3
factors
exhibited
1.95,
1.37–2.77).
corresponding
protective
effects
multiple
modification
influenced
by
intensive
or
standard
antihypertensive
treatment
(P
for
interaction
=
0.71).
Conclusion
stepwise
observed
number
patients.
more
modified,
less
observed,
irrespective
different
strategies.
Comprehensive
strategies
are
warranted
reduce
disease
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
13(1), С. 60 - 60
Опубликована: Дек. 22, 2023
The
aim
of
this
study
is
to
present
data
on
the
use
lipid-lowering
therapy
(LLT)
in
relation
calculated
cardiovascular
risk
(CVR)
and
an
additionally
defined
target
LDL-C
concentration.
cohort
consisted
1287
participants
Polish
edition
Prospective
Urban
Rural
Epidemiological
Study
(PURE).
CVR
was
for
each
participant
using
SCORE2
or
SCORE2-OP
scale,
patients
with
diabetes
mellitus
(DM),
chronic
kidney
disease
(CKD)
atherosclerotic
(ASCVD)
according
respective
criteria.
In
analysed,
107
212
people
(50.5%)
low
group,
284
414
(68.6%)
moderate
562
612
(91.8%)
high
group
48
49
(98%)
very
did
not
meet
LDL-c
criterion.
Of
those
86%
were
receiving
(LLT);
proportion
77.8%;
68.1%
75%.
who
concentration
criterion
take
LLT
made
up
larger
group.