The Related Metabolic Diseases and Treatments of Obesity

Healthcare, Год журнала: 2022, Номер 10(9), С. 1616 - 1616

Опубликована: Авг. 25, 2022

Obesity is a chronic disease characterized by the abnormal or excessive accumulation of body fat, affecting more than 1 billion people worldwide. commonly associated with other metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular diseases, kidney and cancers. Factors sedentary lifestyle, overnutrition, socioeconomic status, environmental genetic conditions can cause obesity. Many molecules signaling pathways are involved in pathogenesis obesity, nuclear factor (NF)-κB, Toll-like receptors (TLRs), adhesion molecules, G protein-coupled (GPCRs), programmed cell death (PD-1)/programmed death-ligand (PD-L1), sirtuin (SIRT1). Commonly used strategies obesity management treatment include exercise dietary change restriction for early stage bariatric surgery server Food Drug Administration (FDA)-approved medicines semaglutide liraglutide that be monotherapy synergistic treatment. In addition, psychological management, especially patients distress, good option. Gut microbiota plays an important role its comorbidities, gut microbial reprogramming fecal transplantation (FMT), probiotics, prebiotics, synbiotics shows promising potential syndrome. clinical trials ongoing to evaluate therapeutic effects different treatments. Currently, prevention best options prevent progression many comorbidities.

Язык: Английский

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Transcriptome-wide association studies: recent advances in methods, applications and available databases

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Сен. 1, 2023

Abstract Genome-wide association study has identified fruitful variants impacting heritable traits. Nevertheless, identifying critical genes underlying those significant been a great task. Transcriptome-wide (TWAS) is an instrumental post-analysis to detect gene-trait associations focusing on modeling transcription-level regulations, which made numerous progresses in recent years. Leveraging from expression quantitative loci (eQTL) regulation information, TWAS advantages detecting functioning regulated by disease-associated variants, thus providing insight into mechanisms of diseases and other phenotypes. Considering its vast potential, this review article comprehensively summarizes TWAS, including the methodology, applications available resources.

Язык: Английский

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Interventions implemented through sporting organisations for promoting healthy behaviour or improving health outcomes

Cochrane library, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 13, 2025

Язык: Английский

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Self‐reported sleep duration and quality and cardiovascular diseases among middle‐aged and older Chinese: A 7‐year longitudinal cohort study

Journal of Clinical Hypertension, Год журнала: 2024, Номер 26(10), С. 1145 - 1154

Опубликована: Авг. 19, 2024

Cardiovascular disease (CVD) is a leading cause of death worldwide, and several studies have attempted to identify its risk factors. This study aimed investigate the association between sleep duration quality, 7-year incidence CVD among middle-aged older Chinese individuals. A total 6682 participants aged 45-90 years from China Health Retirement Longitudinal Study database were included in this study. The authors estimated quality based on self-reported data night hours disturbance symptoms, examined associations them composite outcome using logistic regression models. 1692 (25.32%) reported new events during follow-up. Short (< 6 h/night) was significantly associated with higher all three models (p < .05). However, not observed for long (> 8 h/night). Additionally, mild models, severe Models 2 3 had After stratification by age daytime napping, we still found significant short individuals 45-59 years, non-nappers these ≥60 or nappers > In conclusion, are both an increased

Язык: Английский

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Letter: Exploring the Link Between GGT/ALT Ratio and Carotid Plaque in Coronary Artery Disease

Angiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

Язык: Английский

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Prognostic value of the neutrophil to lymphocyte ratio for cardiovascular diseases: research progress

American Journal of Translational Research, Год журнала: 2025, Номер 17(2), С. 1170 - 1177

Опубликована: Янв. 1, 2025

The neutrophil to lymphocyte ratio (NLR) is a simple, reliable, and easily accessible composite index that has garnered increasing attention in cardiovascular research. NLR closely associated with the onset, progression, prognosis of various diseases. This article reviews etiological prognostic roles conditions such as coronary atherosclerotic heart disease, hypertension, arrhythmia, failure, valvular disease. Studies have shown involved pathophysiologic processes these diseases holds significant predictive value for their prognosis. Additionally, compared other inflammatory markers, offers advantages low cost, repeatability, ability be measured at community-level primary healthcare settings, thus providing new insight prediction like artery

Язык: Английский

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Body mass index and mortality after elective open abdominal aortic aneurysm repair in a fifteen year multicenter cohort study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Июнь 3, 2025

The correlation between body mass index (BMI) and the outcomes for patients receiving surgical intervention abdominal aortic aneurysm (AAA) is still debated. Consequently, this study seeks to investigate association BMI mortality following elective open repair (EOAR). This involves a secondary analysis derived from data collected in prospective cohort framework. It focuses on individuals who received EOAR across ten vascular surgery centers Denmark January 1, 2000, December 31, 2014. employed Cox proportional hazards regression model examine connection EOAR. To detect any potential nonlinear associations, with cubic spline functions smooth curve fitting was utilized. Furthermore, we performed numerous sensitivity subgroup evaluations ensure reliability of our results. Upon controlling confounding variables, demonstrated clear inverse Specifically, each 1 kg/m² increase corresponded 2.7% reduction risk (HR = 0.973; 95% CI: 0.958-0.988). Compared normal weight, those classified as underweight faced 62.6% higher 1.626; 1.142-2.314), whereas overweight obese experienced by 18.2% 0.818; 0.722-0.928) 15.8% 0.842; 0.721-0.998), respectively. Additionally, identified relationship postoperative mortality, critical point at 25.78 kg/m². Below inflection point, decrease significantly increased 8% 0.920; 0.893-0.949). Beyond further increases did not impact risk. In undergoing EOAR, an negatively associated mortality. specific exists Clinicians should carefully weigh risks under consider delaying enhance nutrition. contrast, or may require pre-surgery weight management.

Язык: Английский

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Reduction of NADPH oxidase 4 in adipocytes contributes to the anti-obesity effect of dihydroartemisinin

Heliyon, Год журнала: 2023, Номер 9(3), С. e14028 - e14028

Опубликована: Фев. 25, 2023

Artemisinin derivatives have been found to anti-obesity effects recently, but the mechanism is still controversial. Herein, long-term DHA treatment in obese mice significantly reduced body weight and improved glucose metabolism. However, short-term did not affect metabolism mice, suggesting that with could be secondary reduction. Consistent previous reports, we observed inhibited differentiation of adipocytes. Mechanistically, expression NADPH oxidase 4 (NOX4) white adipose tissue (WAT) differentiated adipocytes, using NOX4 siRNA or inhibitor GKT137831 attenuated adipocyte differentiation. Over-expression partially reversed inhibition effect on adipogenic preadipocytes. In addition, targeted proteomics analysis showed abnormality metabolic pathways. conclusion, fat mass possibly by inhibiting suppress lipid accumulation

Язык: Английский

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Influence of multiple risk factor control level on cardiovascular outcomes in hypertensive patients

European Heart Journal - Quality of Care and Clinical Outcomes, Год журнала: 2024, Номер unknown

Опубликована: Июль 11, 2024

Abstract Aims The relationship between the level of baseline risk factor control and cardiovascular outcomes in hypertensive patients with blood pressure interventions is not well understood. It also unclear whether persuasively associated a lowering strategy. Method results We performed an analysis Strategy Blood Pressure Intervention Elderly Hypertensive Patients (STEP) trial. Participants without complete data were excluded. primary outcome was composite events all-cause mortality. Cox proportional hazard models used to calculate ratio (HR) estimate association levels (≥6, 5, 4, ≤3) outcomes. A total 8337 participants involved analysis, median follow-up period 3.19 years. Each additional uncontrolled 24% higher (HR 1.24, 95% CI 1.11–1.37). Compared optimal control, those ≤3 factors exhibited 1.95, 1.37–2.77). corresponding protective effects multiple modification influenced by intensive or standard antihypertensive treatment (P for interaction = 0.71). Conclusion stepwise observed number patients. more modified, less observed, irrespective different strategies. Comprehensive strategies are warranted reduce disease

Язык: Английский

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Lipid-Lowering Therapy in PURE Poland Cohort Study

Journal of Clinical Medicine, Год журнала: 2023, Номер 13(1), С. 60 - 60

Опубликована: Дек. 22, 2023

The aim of this study is to present data on the use lipid-lowering therapy (LLT) in relation calculated cardiovascular risk (CVR) and an additionally defined target LDL-C concentration. cohort consisted 1287 participants Polish edition Prospective Urban Rural Epidemiological Study (PURE). CVR was for each participant using SCORE2 or SCORE2-OP scale, patients with diabetes mellitus (DM), chronic kidney disease (CKD) atherosclerotic (ASCVD) according respective criteria. In analysed, 107 212 people (50.5%) low group, 284 414 (68.6%) moderate 562 612 (91.8%) high group 48 49 (98%) very did not meet LDL-c criterion. Of those 86% were receiving (LLT); proportion 77.8%; 68.1% 75%. who concentration criterion take LLT made up larger group.

Язык: Английский

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