Authorea (Authorea),
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 17, 2023
Authors:
Hsueh-Sheng
Chiang1,2*,
Raksha
A.
Mudar3,
Christine
S.
Dugas2,
Michael
Motes2,
Kraut4,
John
Hart
Jr.1,2Affiliations:1.
Department
of
Neurology,
University
Texas
Southwestern
Medical
Center.
5303
Harry
Hines
Blvd
8th
floor,
Dallas,
TX
75390,
USA2.
School
Behavioral
and
Brain
Sciences,
The
at
800
W
Campbell
Rd,
Richardson,
75080,
USA3.
Speech
Hearing
Science,
Illinois
Urbana-Champaign,
901
S
6th
St,
Champaign,
IL
61820,
USA4.
Radiology
Radiological
Johns
Hopkins
University.
1800
Orleans
St.
Baltimore,
MD
21287,
USA
Current Neurology and Neuroscience Reports,
Год журнала:
2022,
Номер
22(12), С. 855 - 865
Опубликована: Ноя. 16, 2022
Abstract
Purpose
of
Review
Thalamic
aphasia
is
a
rare
language
disorder
resulting
from
lesions
to
the
thalamus.
While
most
patients
exhibit
mild
symptoms
with
predominance
lexical-semantic
difficulties,
variations
in
phenotype
have
been
described.
Overall,
exact
mechanisms
thalamic
await
empirical
research.
The
article
reviews
recent
findings
regarding
phenotypes
and
possible
underlying
aphasia.
Recent
Findings
Variations
may
be
related
different
lesion
locations.
thalamus’
role
thought
due
its
involvement
cortico-thalamic
networks
lesioning
certain
nuclei
diachisis
otherwise
interconnected
areas.
Its
monitoring
function
such
network
might
cellular
firing
modes.
However,
no
specific
evidence
has
collected
date.
Summary
show
more
distinct
understanding
mechanisms,
further
research
needed.
Additionally,
as
standard
testing
oftentimes
not
pick
up
on
subtle
symptoms,
underdiagnosed.
NeuroImage,
Год журнала:
2024,
Номер
295, С. 120664 - 120664
Опубликована: Май 31, 2024
Stroke
often
damages
the
basal
ganglia,
leading
to
atypical
and
transient
aphasia,
indicating
that
post-stroke
ganglia
aphasia
(PSBGA)
may
be
related
different
anatomical
structural
damage
functional
remodeling
rehabilitation
mechanisms.
The
contain
dense
white
matter
tracts
(WMTs).
Hence,
tract
an
essential
basis
for
development
of
PSBGA.
Diagnostics,
Год журнала:
2023,
Номер
13(12), С. 2003 - 2003
Опубликована: Июнь 8, 2023
The
pathophysiology
of
lacunar
infarction
is
an
evolving
and
debated
field,
where
relevant
information
comes
from
histopathology,
old
anatomical
studies
animal
models.
Only
in
the
last
years,
have
neuroimaging
techniques
allowed
a
sufficient
resolution
to
directly
or
indirectly
assess
dynamic
evolution
small
vessel
occlusion
formulate
hypotheses
about
tissue
status
mechanisms
damage.
core–penumbra
concept
was
extensively
explored
large
occlusions
(LVOs)
both
experimental
clinical
point
view.
Then,
perfusion
thresholds
on
one
side
studying
brain
were
focused
optimized
for
LVOs.
presence
deficit
territory
single
perforating
artery
negated
years
until
recent
proposal
existence
defect
subgroup
infarcts
by
using
magnetic
resonance
imaging
(MRI).
This
finding
opens
pathophysiological
triggers
neurovascular
multidisciplinary
reasoning
how
image
this
acute
phase
particular.
aim
review
summarize
issues
application
hypothesis
stroke.
Brain,
Год журнала:
2024,
Номер
147(6), С. 2245 - 2257
Опубликована: Янв. 18, 2024
Abstract
Advanced
methods
of
imaging
and
mapping
the
healthy
lesioned
brain
have
allowed
for
identification
cortical
nodes
white
matter
tracts
supporting
dual
neurofunctional
organization
language
networks
in
a
dorsal
phonological
ventral
semantic
stream.
Much
less
understood
are
anatomical
correlates
interaction
between
two
streams;
one
hypothesis
being
that
subcortically
mediated
interaction,
through
crossed
cortico-striato-thalamo-cortical
cortico-thalamo-cortical
loops.
In
this
regard,
pulvinar
is
thalamic
subdivision
has
most
regularly
appeared
as
implicated
processing
lexical
retrieval.
However,
descriptions
its
connections
with
temporal
(language)
areas
remain
scarce.
Here
we
assess
pulvino-temporal
connectivity
using
combination
state-of-the-art
techniques:
stimulation
awake
surgery
postoperative
diffusion
MRI
(n
=
4),
virtual
dissection
from
Human
Connectome
Project
3
7
T
datasets
172)
operative
microscope-assisted
post-mortem
fibre
12).
We
demonstrate
presence
four
fundamental
contingents:
(i)
anterior
component
(Arnold’s
bundle
proper)
initially
described
by
Arnold
19th
century
destined
to
lobe;
(ii)
optic
radiations-like
component,
which
leaves
accompanying
optical
radiations
reaches
posterior
basal
cortices;
(iii)
lateral
crosses
stem
orthogonally
middle
gyrus;
(iv)
auditory
superomedial
aspect
operculum,
just
posteriorly
Heschl’s
gyrus.
Each
those
components
might
correspond
different
level
information
involved
retrieval
process
picture
naming.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 28, 2024
Abstract
Background
and
Objectives
Spatial
neglect
is
commonly
attributed
to
lesions
of
a
predominantly
right-hemispheric
cortical
network.
Although
spatial
was
also
repeatedly
observed
after
the
basal
ganglia
thalamus,
many
anatomical
network
models
omit
these
structures.
We
investigated
if
disruption
functional
or
structural
connectivity
can
explain
in
subcortical
stroke.
Methods
retrospectively
data
first-ever,
acute
stroke
patients
with
right-sided
(n
=
27)
thalamus
16).
Based
on
lesion
location,
we
estimated
i)
via
lesion-network
mapping
normative
resting
state
fMRI
data,
ii)
white
matter
disconnection
iii)
tract-wise
association
fibres
based
tractography
investigate
measures.
Results
Apart
from
very
small
clusters
inferior/middle
frontal
regions
symptom
for
lesions,
our
analyses
found
no
evidence
subcortico-cortical
disconnection.
Instead,
multivariate
consideration
load
several
predicted
occurrence
(p
0.0048;
AUC
0.76),
which
were
superior
longitudinal
fasciculus,
inferior
occipitofrontal
uncinate
fasciculus.
Conclusion
Disconnection
long
(cortico-cortical)
Like
competing
theory
remote
hypoperfusion,
this
mechanism
does
not
require
assumption
genuine
role
grey
structures
neglect.
