SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms DOI Open Access
Joanna Motyl, Grażyna Gromadzka, Grzegorz A. Czapski

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12079 - 12079

Опубликована: Ноя. 10, 2024

Alpha-synuclein (α-syn) is a 140-amino-acid, intrinsically disordered, soluble protein that abundantly present in the brain. It plays crucial role maintaining cellular structures and organelle functions, particularly supporting synaptic plasticity regulating neurotransmitter turnover. However, for reasons not yet fully understood, α-syn can lose its physiological begin to aggregate. This altered disrupts dopaminergic transmission causes both presynaptic postsynaptic dysfunction, ultimately leading cell death. A group of neurodegenerative diseases known as α-synucleinopathies characterized by intracellular accumulation deposits specific neuronal glial cells within certain brain regions. In addition Parkinson's disease (PD), these conditions include dementia with Lewy bodies (DLBs), multiple system atrophy (MSA), pure autonomic failure (PAF), REM sleep behavior disorder (RBD). Given disorders are associated α-syn-related neuroinflammation-and considering SARS-CoV-2 infection has been shown affect nervous system, COVID-19 patients experiencing neurological symptoms-it proposed may contribute neurodegeneration PD other promoting misfolding aggregation. this review, we focus on whether could act an environmental trigger facilitates onset or progression α-synucleinopathies. Specifically, new evidence potential modulating function discuss causal relationship between development parkinsonism-like symptoms.

Язык: Английский

Circadian rhythm disruption: a potential trigger in Parkinson’s disease pathogenesis DOI Creative Commons
Ke Xu, Yu Zhang, Yue Shi

и другие.

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 30, 2024

Parkinson's disease (PD) is a neurodegenerative characterized by the gradual loss of dopaminergic neurons in substantia nigra pars compacta (SNpc), abnormal accumulation α-synuclein (α-syn), and activation microglia leading to neuroinflammation. Disturbances circadian rhythm play significant role PD, with most non-motor symptoms associated disruptions rhythm. These disturbances can be observed years before motor appear are marked emergence related such as rapid eye movement sleep behavior disorder (RBD), restless leg syndrome (RLS), excessive daytime sleepiness (EDS), depression anxiety, changes blood pressure, gastrointestinal dysfunction, urinary problems. Circadian disruption precedes onset contributes progression PD. In brief, this article outlines triggering PD at cellular molecular levels, well its clinical manifestations. It also explores how research contribute preventing from current future perspectives.

Язык: Английский

Процитировано

2
The use of prolonged-release melatonin in circadian medicine: a systematic review DOI Creative Commons
Antonio Del Casale, Jan Francesco Arena, Francesca Giannetti

и другие.

Minerva Medica, Год журнала: 2024, Номер 115(2)

Опубликована: Май 1, 2024

Melatonin, a hormone produced by the pineal gland, regulates sleep-wake cycle and is effective in restoring biological rhythms. Prolonged-release melatonin (PRM) designed to mimic natural physiological pattern of release. In circadian medicine, PRM can be used treat sleep rhythm disorders, as well numerous organic diseases associated with disorders.

Язык: Английский

Процитировано

1
SARS-CoV-2 Infection and Alpha-Synucleinopathies: Potential Links and Underlying Mechanisms DOI Open Access
Joanna Motyl, Grażyna Gromadzka, Grzegorz A. Czapski

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12079 - 12079

Опубликована: Ноя. 10, 2024

Alpha-synuclein (α-syn) is a 140-amino-acid, intrinsically disordered, soluble protein that abundantly present in the brain. It plays crucial role maintaining cellular structures and organelle functions, particularly supporting synaptic plasticity regulating neurotransmitter turnover. However, for reasons not yet fully understood, α-syn can lose its physiological begin to aggregate. This altered disrupts dopaminergic transmission causes both presynaptic postsynaptic dysfunction, ultimately leading cell death. A group of neurodegenerative diseases known as α-synucleinopathies characterized by intracellular accumulation deposits specific neuronal glial cells within certain brain regions. In addition Parkinson's disease (PD), these conditions include dementia with Lewy bodies (DLBs), multiple system atrophy (MSA), pure autonomic failure (PAF), REM sleep behavior disorder (RBD). Given disorders are associated α-syn-related neuroinflammation-and considering SARS-CoV-2 infection has been shown affect nervous system, COVID-19 patients experiencing neurological symptoms-it proposed may contribute neurodegeneration PD other promoting misfolding aggregation. this review, we focus on whether could act an environmental trigger facilitates onset or progression α-synucleinopathies. Specifically, new evidence potential modulating function discuss causal relationship between development parkinsonism-like symptoms.

Язык: Английский

Процитировано

1