Puzzle of Proteoform Variety—Where Is a Key?
Proteomes,
Год журнала:
2024,
Номер
12(2), С. 15 - 15
Опубликована: Май 10, 2024
One
of
the
human
proteome
puzzles
is
an
imbalance
between
theoretically
calculated
and
experimentally
measured
amounts
proteoforms.
Considering
possibility
combinations
different
post-translational
modifications
(PTMs),
quantity
possible
proteoforms
huge.
An
estimation
gives
more
than
a
million
in
each
cell
type.
But,
it
seems
that
there
strict
control
over
production
maintenance
PTMs.
Although
potential
complexity
due
to
PTMs
tremendous,
available
information
indicates
only
small
part
being
implemented.
As
result,
protein
could
have
many
according
number
modification
sites,
but
because
systems
personal
regulation,
profile
for
given
organism
slightly
different.
Язык: Английский
Recent Advancements and Innovations in Pediatric Precision Oncology
Journal of Pediatric Hematology/Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 10, 2024
Precision
oncology
incorporates
comprehensive
genomic
profiling
into
the
individualized
clinical
care
of
pediatric
cancer
patients.
In
recent
years,
pan-cancer
analyses
have
led
to
successful
implementation
genomics-based
trials
and
accelerated
approval
novel
targeted
agents.
addition,
disease-specific
studies
resulted
in
molecular
subclassification
myriad
types
with
subsequent
tailoring
treatment
intensity
based
on
patient's
prognostic
factors.
This
review
discusses
progress
field
highlights
developments
that
are
leading
more
personalized
improved
patient
outcomes.
Increased
understanding
evolution
precision
over
decades
emphasizes
tremendous
impact
applications.
New
technologies
diagnostic
modalities
offer
further
promise
for
future
advancements
within
field.
Язык: Английский
Advances in Fourier infrared spectroscopy for noninvasive diagnosis of diabetes mellitus: Analysis and prospects for application based on blood, urine and saliva samples
Microchemical Journal,
Год журнала:
2024,
Номер
207, С. 111764 - 111764
Опубликована: Сен. 24, 2024
Язык: Английский
Extracellular Vesicles from Plasma of Patients with Glioblastoma Promote Invasion of Glioblastoma Cells Even After Tumor Resection
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2834 - 2834
Опубликована: Дек. 13, 2024
Background:
Glioblastoma
(GB)
is
a
highly
aggressive
tumor,
whose
progression
mediated
by
secretion
of
extracellular
vesicles
(EVs),
which
can
pass
the
brain–blood
barrier
and
be
found
in
plasma.
Here,
we
performed
comparative
analysis
effects
EVs
from
plasma
healthy
donors
(hEVs)
GB
patients
before
(bEVs)
after
(aEVs)
tumor
surgical
resection
on
invasion
normal
astrocytes
cells.
Methods:
We
transwell
assay,
analyzed
MAP
kinases
activation
Western
blotting,
studied
SNAI1/SNAI2
cellular
localization
confocal
microscopy,
measured
cadherins
expression
flow
cytometry,
cytokines,
regulate
migration
inflammation,
immunoassay.
Results:
hEVs
did
not
affect
cells,
there
was
down-regulated
astrocytes,
while
increased
E-
N-cadherin
inflammation
adhesion
regulators
both
bEVs
enhanced
cells
but
via
AKT,
JNK1/2/3,
p38
activation,
stimulated
clasterization
SNAI1
cell
nucleus,
promoted
an
E/N
cadherin
switch,
caused
aEVs
exhibited
most
pro-oncogenic
(stimulation
invasion,
nuclear
localization,
JNK1/2/3
cells).
However,
were
less
pronounced
than
those
bEVs.
Conclusions:
In
our
study,
revealed
common
different
plasma-derived
hEVs,
aEVs,
stimulate
some
Being
tumorigenic
then
bEVs,
are
still
able
to
promote
probably
remaining
resection.
Язык: Английский