Effects of natural source polysaccharides on neurological diseases: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 139697 - 139697
Опубликована: Янв. 1, 2025
Язык: Английский
Extracranial Effects of Traumatic Brain Injury: A Narrative Review
Clinics and Practice,
Год журнала:
2025,
Номер
15(3), С. 47 - 47
Опубликована: Фев. 25, 2025
Background:
Traumatic
brain
injury
(TBI)
is
often
associated
with
other
injuries
and
comorbidities.
However,
even
isolated
TBI
directly
leads
to
dysfunction
in
multiple
body
systems
outside
the
central
nervous
system.
These
extracranial
effects
of
target
including
autonomic
nervous,
cardiovascular,
renal,
pulmonary,
immune,
gastrointestinal,
hemostasis
systems,
as
well
causing
significant
alteration
systemic
metabolism.
Aim:
This
review
intended
outline
on
place
these
context
treatment
considerations
for
patients.
Significance:
Systemic
have
implications
acute
critical
care
management
patients
TBI,
pharmacologic
treatment.
They
also
affect
decisions
chronic
care,
TBI-unrelated
routine
medical
TBI.
In
addition,
should
be
considered
research
settings.
Conclusions:
It
important
clinicians
researchers
aware
effects,
consider
their
pathology,
decisions,
interpretation
findings.
Язык: Английский
Detection of NLRP3, ASC, and Caspase-1 in serum and cerebrospinal fluid of traumatic brain injury patients: implications for short-term prognosis
Adilijiang Aihemaitiniyazi,
K. Ma,
Jinhui Xu
и другие.
Acta Neurologica Belgica,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Abstract
Objectives
Traumatic
brain
injury
(TBI)
is
a
critical
public
health
issue
with
high
mortality
and
disability
rates.
Current
diagnostic
tools
lack
sensitivity
specificity,
under-scoring
the
need
for
novel
biomarkers.
This
study
aimed
to
evaluate
clinical
utility
of
NLRP3,
ASC,
Caspase-1
as
biomarkers
assessing
TBI
severity
prognosis.
Methods
A
prospective
cohort
89
patients
moderate-to-severe
was
studied.
Blood
cerebrospinal
fluid
(CSF)
samples
were
collected
four
consecutive
days
post-injury.
Levels
measured
using
enzyme-linked
immunosorbent
as-say
(ELISA).
Statistical
analyses,
including
ROC
curve
analysis,
conducted
assess
their
predictive
performance.
Results
levels
in
both
serum
CSF
significantly
elevated
patients,
higher
correlating
greater
severity.
analysis
revealed
that
biomarkers,
particularly
demonstrated
superior
value.
NLRP3
on
1,
2,
4
had
AUC
values
0.9871,
0.9466,
0.8967,
respectively.
Dynamic
changes
these
over
time
provided
insights
into
disease
progression
Serum
markers,
while
less
than
CSF,
also
effective
Conclusions
are
promising
evaluating
predicting
outcomes.
Their
dynamic
monitoring
may
improve
management
in-form
therapeutic
strategies.
Future
research
should
validate
findings
larger
cohorts
explore
interventions
targeting
inflammatory
pathways.
Язык: Английский
Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 11, 2025
Язык: Английский
Integrated Scrna-Seq Analysis Reveal Gene Expression Dynamics in Myeloid Cells and Nk Cells During Stroke Recovery
Опубликована: Янв. 1, 2025
Язык: Английский
Potential Correlation Between Molecular Biomarkers and Oxidative Stress in Traumatic Brain Injury
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3858 - 3858
Опубликована: Апрель 18, 2025
Diagnosing
traumatic
brain
injury
(TBI)
remains
challenging
due
to
an
incomplete
understanding
of
its
neuropathological
mechanisms.
TBI
is
recognised
as
a
complex
condition
involving
both
primary
and
secondary
injuries.
Although
oxidative
stress
non-specific
molecular
phenomenon
observed
in
various
conditions,
it
plays
crucial
role
response
recovery.
Due
these
aspects,
we
aimed
evaluate
the
interaction
between
some
known
biomarkers
providing
evidence
for
possible
relevance
clinical
diagnosis
outcome
prediction.
We
found
that
while
many
currently
validated
interact
with
pathways,
their
patterns
variation
could
assist
diagnosis,
prognosis,
outcomes
prediction
cases.
Язык: Английский
Circulating Brain-Reactive Autoantibody Profiles in Military Breachers Exposed to Repetitive Occupational Blast
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13683 - 13683
Опубликована: Дек. 21, 2024
Military
breachers
are
routinely
exposed
to
repetitive
low-level
blast
overpressure,
placing
them
at
elevated
risk
for
long-term
neurological
sequelae.
Mounting
evidence
suggests
that
circulating
brain-reactive
autoantibodies,
generated
following
CNS
injury,
may
serve
as
both
biomarkers
of
cumulative
damage
and
drivers
secondary
neuroinflammation.
In
this
study,
we
compared
autoantibody
profiles
in
military
(n
=
18)
with
extensive
exposure
against
unexposed
controls
19).
Using
high-sensitivity
immunoassays,
quantified
IgG
IgM
autoantibodies
targeting
glial
fibrillary
acidic
protein
(GFAP),
myelin
basic
(MBP),
pituitary
(PIT)
antigens.
Breachers
exhibited
significantly
levels
anti-GFAP
(p
<
0.001)
anti-PIT
controls,
while
anti-MBP
remained
unchanged.
No
significant
differences
were
observed
any
measurements.
These
patterns
suggest
induces
a
chronic,
adaptive
immune
response
rather
than
short-lived
acute
phase.
The
highlight
the
vulnerability
astrocytes,
myelin,
hypothalamic–pituitary
axis
ongoing
immune-mediated
injury
repeated
insults,
likely
reflecting
sustained
blood–brain
barrier
disruption
neuroinflammatory
processes.
Our
findings
underscore
potential
CNS-targeted
brain
dysregulation
blast-exposed
populations.
Further
research
is
warranted
validate
these
markers
larger,
more
diverse
cohorts,
explore
their
utility
guiding
interventions
aimed
mitigating
neuroinflammation,
neuroendocrine
dysfunction,
neurodegenerative
risks
personnel
similarly
groups.
Язык: Английский