Understanding the Consequences of Fatty Bone and Fatty Muscle: How the Osteosarcopenic Adiposity Phenotype Uncovers the Deterioration of Body Composition

Metabolites, Год журнала: 2023, Номер 13(10), С. 1056 - 1056

Опубликована: Окт. 7, 2023

Adiposity is central to aging and several chronic diseases. encompasses not just the excess adipose tissue but also body fat redistribution, infiltration, hypertrophy of adipocytes, shifting mesenchymal stem cell commitment adipogenesis. Bone marrow expansion, inflammatory adipokines, adipocyte-derived extracellular vesicles are development osteopenic adiposity. Adipose infiltration local adipogenesis within muscle critical in developing sarcopenic adiposity subsequent poorer functional outcomes. Ultimately, osteosarcopenic syndrome result all processes noted above: adipocyte expansion redistribution bone, muscle, tissues, resulting bone loss, mass/strength deteriorated tissue, decline. Increased typically referred as obesity expressed by mass index (the latter often used inadequately), now occurring younger age groups, suggesting people will live longer with negative effects This review discusses role deterioration well itself. It reveals how considering including definition diagnosis adiposity, help better understanding pathophysiology each accelerate possible therapies prevention approaches for both relatively healthy individuals or those disease.

Язык: Английский

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Fat Body Mass and Vertebral Fracture Progression in Women With Breast Cancer

JAMA Network Open, Год журнала: 2024, Номер 7(1), С. e2350950 - e2350950

Опубликована: Янв. 10, 2024

Importance Women with early breast cancer (EBC) exposed to aromatase inhibitors (AIs) may experience fragility fractures despite treatment bone-active drugs. Risk factors for in patients receiving AIs and denosumab have not been explored date. Objectives To evaluate whether an association exists between dual x-ray absorptiometry (DXA)–measured fat body mass (FBM) vertebral fracture (VF) progression postmenopausal women EBC undergoing adjuvant therapy combination examine VF was associated common risk bone parameters of composition other than FBM. Design, Setting, Participants For this prospective, single-center, cohort study, 237 who were (60 mg every 6 months) enrolled at the Breast Unit ASST Spedali Civili Brescia from September 2014 June 2018. Data analysis conducted 2022. Exposure Body parameters, mineral density, morphometric VFs assessed by DXA study entry after 18 months therapy. Main Outcomes Measures progression, defined as either new or worsening preexisting VFs, 2 time points. Results Of (median [range] age, 61 [28-84] years), 17 (4.4%) reported progression. Univariable found a history clinical (odds ratio [OR], 3.22; 95% CI, 1.19-8.74; P = .02), Fracture Assessment Tool (FRAX) score major (OR, 4.42; 1.23-13.79; .04), percentage FBM 6.04; 1.69-21.63; .006), android 9.58; 1.17-78.21; .04) inverse appendicular lean index–FBM 0.25, 0.08-0.82; .02). Multivariable revealed 5.41; 1.49-19.59; .01) FRAX 3.95; 1.09-14.39; independent variables Conclusions Relevance The findings suggest that baseline is factor treated denosumab. This observation indicates diet exercise synergize management health patient setting.

Язык: Английский

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Bone-active drugs in premenopausal women with breast cancer under hormone-deprivation therapies

European Journal of Endocrinology, Год журнала: 2024, Номер 191(2), С. 117 - 125

Опубликована: Июль 25, 2024

Abstract Background Bone health management in premenopausal women with breast cancer (BC) under hormone-deprivation therapies (HDTs) is often challenging, and the effectiveness of bone-active drugs still unknown. Methods This retrospective multicenter study included 306 early BC undergoing HDTs. mineral density (BMD) morphometric vertebral fractures (VFs) were assessed 12 months after HDT initiation then at least 24 months. Results After initial assessment, prescribed 77.5% (151 denosumab 60 mg/6 months, 86 bisphosphonates). 47.0 ± 20.1 new VFs found 16 (5.2%). Vertebral fracture risk was significantly associated obesity (odds ratio [OR] 3.87, P = .028), family history hip or (OR 3.21, .040], chemotherapy-induced menopause 6.48, < .001), preexisting 25.36, baseline T-score less than equal to −2.5 standard deviation (SD) any skeletal site 4.14, .036), changes lumbar total BMD 0.94, .038 OR 0.88, .001, respectively). New occurred more frequently untreated compared those treated (14/69, 20.8% vs 2/237, 0.8%; .001) anti-fracture remained significant correction for BMI 0.03; 0.04; 0.01; .001). Conclusions Premenopausal HDTs are high relationship BMI, densitometric diagnosis osteoporosis, VFs, osteoporotic fractures. this setting might be effectively prevented by bisphosphonates denosumab.

Язык: Английский

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Total and Regional Changes in Body Composition in Metastatic Hormone-sensitive Prostate Cancer Patients Randomized to Receive Androgen Deprivation + Enzalutamide ± Zoledronic Acid. The BONENZA Study

European Urology Oncology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

The reduction of lean body mass (LBM) and the increase fat (FBM) caused by androgen deprivation therapy (ADT) administered to prostate cancer patients are well known lead an increased risk sarcopenia. effects addition receptor pathway inhibitors (ARPIs) ADT on composition have not been studied thoroughly. BONENZA (NCT03336983) is a prospective phase 2 trial in which metastatic hormone-sensitive were randomized receive plus enzalutamide with (EZ arm) or without (E zoledronic acid. Total regional parameters evaluated dual-energy x-ray absorptiometry (DXA) scans at baseline after 18 mo therapy. Eighty-nine (46 from EZ arm 43 E had paired DXA evaluation both time points. After therapy, FBM +22.8% (p < 0.001), LBM reduced -6.7% appendicular index (ALMI) decreased -9.2% 0.001). varied considerably according districts: +36.1% right arms 0.001) +3.7% head 0.01). Similarly, decrease ranged -9.4% -6.4% trunk. None met criteria for sarcopenic obesity; however, treatment, 11.76% >40.8%, 3.5% ALMI <5.5, ALMI/FBM ratio -23.9% Age influenced these changes significantly, younger (<70 yr) those higher experiencing more marked changes. Body undergoes significant change ARPIs ADT, LBM, twice as high expected alone. has proved be reliable tool monitoring composition, assessment district variations can aid implementing individual-supervised physical exercise prevent obesity.

Язык: Английский

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Bone health and body composition in prostate cancer: Meet-URO and AIOM consensus about prevention and management strategies

ESMO Open, Год журнала: 2024, Номер 9(7), С. 103484 - 103484

Опубликована: Июнь 19, 2024

Prostate cancer (PCa) treatments are associated with a detrimental impact on bone health (BH) and body composition. However, the evidence these issues is limited contradictory. This consensus, based Delphi method, provides further guidance BH management in PCa.

Язык: Английский

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Changes in body composition in early breast cancer patients treated with aromatase inhibitors

Journal of Endocrinological Investigation, Год журнала: 2024, Номер unknown

Опубликована: Июнь 10, 2024

Язык: Английский

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Prediction of fragility fractures in men with prostate cancer under androgen deprivation therapy: the importance of a multidisciplinary approach using a mini-invasive diagnostic tool

Endocrine, Год журнала: 2023, Номер 83(3), С. 594 - 596

Опубликована: Дек. 19, 2023

Язык: Английский

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Bilateral aseptic loosening of glenoid and humeral components after anatomic shoulder arthroplasty: a case report

Seminars in Arthroplasty JSES, Год журнала: 2024, Номер 34(3), С. 755 - 761

Опубликована: Сен. 1, 2024

Язык: Английский

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Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune–Inflammatory–Metabolic Markers and Related Conceptual Issues

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(13), С. 3969 - 3969

Опубликована: Июль 7, 2024

: This study, based on the concept of immuno-inflammatory-metabolic (IIM) dysregulation, investigated and compared prognostic impact 27 indices at admission for prediction postoperative myocardial injury (PMI) and/or hospital death in hip fracture (HF) patients.

Язык: Английский

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