Prostate Cancer and Obesity: Current Hypotheses and Challenges DOI Creative Commons
Jillian L. Capodice,

Philippa Cheetham,

Robert Stewart

и другие.

International Journal of Cancer Care and Delivery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Prostate cancer is the most common diagnosed in males United States. Known prostate risk factors include age, ethnicity, and genetic factors. There some data suggesting that obesity a factor for numerous aspects related to including development, biochemical recurrence, mortality. Moreover, there may be potential therapeutic complications obese patient. Weight loss has also been shown benefit patient with cancer. Finally, affect microbiome other molecular pathways such alterations adipokine signaling, insulin insulin-like growth 1 pathway, effects on tumor microenvironment (e.g.: ectopic/periprostatic fat). The purpose of this review discuss current hypotheses relationship between across broad spectrum relationships.

Язык: Английский

Obesity, dietary interventions and microbiome alterations in the development and progression of prostate cancer DOI Creative Commons
Shaun Trecarten, Michael A. Liss, Jill Hamilton‐Reeves

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

The role of the microbiome in prostate cancer is an emerging subject research interest. Certain lifestyle factors, such as obesity and diet, can also impact microbiome, which has been implicated many diseases, heart disease diabetes. However, this link yet to be explored detail context cancer. purpose review explore cross-talk between obesity, dietary interventions, alterations development progression Many possible mechanisms exist linking interventions gut produces metabolites that could play a oncogenesis, including short-chain fatty acids, cholesterol derivatives, folic acid. plays pivotal tumor microenvironment (TME), contributing inflammation, local tissue hypoxia, epithelial-mesenchymal transition. A bidirectional relationship exists certain diets enact changes its associated metabolites, outcomes. Cross-talk To further our understanding, future human studies should investigate incorporate assessment microbiome-derived cellular/immune TME.

Язык: Английский

Процитировано

0
Is the Microbiome Enough: Role of Diet and Metabolites in Our Interventions DOI
Michael A. Liss

European Urology Focus, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Prostate Cancer and Obesity: Current Hypotheses and Challenges DOI Creative Commons
Jillian L. Capodice,

Philippa Cheetham,

Robert Stewart

и другие.

International Journal of Cancer Care and Delivery, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Prostate cancer is the most common diagnosed in males United States. Known prostate risk factors include age, ethnicity, and genetic factors. There some data suggesting that obesity a factor for numerous aspects related to including development, biochemical recurrence, mortality. Moreover, there may be potential therapeutic complications obese patient. Weight loss has also been shown benefit patient with cancer. Finally, affect microbiome other molecular pathways such alterations adipokine signaling, insulin insulin-like growth 1 pathway, effects on tumor microenvironment (e.g.: ectopic/periprostatic fat). The purpose of this review discuss current hypotheses relationship between across broad spectrum relationships.

Язык: Английский

Процитировано

2