Innovative nanoparticle-based approaches for modulating neutrophil extracellular traps in diseases: from mechanisms to therapeutics

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 6, 2025

Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.

Язык: Английский

---

Rural-Urban Disparity in Premature Cancer Mortality in Young People Aged 15–44 Years in China, 2004–2021

International Journal of Public Health, Год журнала: 2025, Номер 70

Опубликована: Фев. 12, 2025

Objective This study aims to examine and compare premature cancer mortality in young people aged 15–44 years old between rural urban areas inform early-onset prevention. Methods The data were obtained from the China Death Surveillance Datasets 2004 2021. sample consisted of deaths old. Age-standardized rates (ASMRs) calculated, joinpoint regressions used trends ASMRs. Results There overall decreasing ASMRs for all cancers both However, decrease was relatively slower areas, where pancreatic ovarian showed increasing trends. five leading types consistently remained liver, lung, leukemia, stomach, other after 2013. Conclusion Our findings indicate that there rural-urban disparities people, which a different pattern compared age groups. More efforts are needed develop effective prevention strategies, with particular emphasis on liver areas.

Язык: Английский

---

Single molecule recognition of CD95 receptors on the surface of HepG2 cells under the curcumin

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2025, Номер 263, С. 116917 - 116917

Опубликована: Апрель 24, 2025

Язык: Английский

---

Gamma-Glutamyl Transpeptidase to Neutrophil Ratio: Prognostic Indicator for Hepatocellular Carcinoma Patients Post-Curative Resection [Letter]

Journal of Hepatocellular Carcinoma, Год журнала: 2024, Номер Volume 11, С. 2391 - 2392

Опубликована: Дек. 1, 2024

Язык: Английский

---