Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116713 - 116713
Опубликована: Дек. 1, 2024
Язык: Английский
Brain Sciences, Год журнала: 2023, Номер 13(5), С. 827 - 827
Опубликована: Май 20, 2023
The pineal gland (PG) is a small interhemispheric brain structure that influences human physiology in many ways, most importantly via secretion of the hormone melatonin which known to regulate sleep and wakefulness. Here, we systematically reviewed existing neuroimaging studies PG structure, and/or release (MLT) psychosis mood disorders. Medline, PubMed, Web Science databases were searched (on 3 February 2023), yielding 36 (8 volume, 24 MLT). findings showed smaller-than-normal volume people with schizophrenia, regardless symptom severity illness stage; major depression, some indication this being present only certain subgroups, or those high scores on ‘loss interest’ symptom. There was considerable evidence lower-than-normal MLT as well aberrant pattern schizophrenia. A similar picture, though less consistent than seen emerged depression bipolar disorder, transient lowering following initiation antidepressants drug-withdrawn patients. Overall, aberrations appear represent transdiagnostic biomarkers for disorders, but further work needed establish their clinical correlates treatment implications.
Язык: Английский
Процитировано
9
Functional & Integrative Genomics, Год журнала: 2024, Номер 24(5)
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
2
Sleep Medicine, Год журнала: 2023, Номер 113, С. 198 - 214
Опубликована: Ноя. 29, 2023
Язык: Английский
Процитировано
6
NeuroImage, Год журнала: 2024, Номер 290, С. 120576 - 120576
Опубликована: Март 13, 2024
To elucidate how time of day, sex, and age affect functional connectivity (FC) in mice, we aimed to examine whether the mouse connectome varied with day/night cycle it depended on sex age. We explored C57Bl6/J mice (6♀ 6♂) at mature (5 ± 1 months) middle-age (14 months). Each underwent Blood Oxygen-Level-Dependent (BOLD) resting-state MRI (rs-fMRI) a 7T scanner four different times two under light condition dark condition. Data processing consisted group independent component analysis (ICA) region-level using networks (RSNs) derived from literature. Linear mixed-effect models (LMEM) were used assess effects lighting their interactions for each RSN obtained group-ICA (RSNs-GICA) six bilateral RSNs adapted literature (RSNs-LIT). Our study highlighted new related alternation addition other already reported In found sex-related differences brain activation only one RSNs-GICA comprising cortical, hippocampal, midbrain cerebellar regions right hemisphere. males, activity was significantly higher left hippocampus, retrosplenial cortex, superior colliculus, cerebellum regardless condition; consistent role these structures memory formation integration, sleep, sex-differences processing. Experimental constraints limited impact light/dark middle-aged females. detected significant pineal gland during condition, finding line nocturnal this gland. For RSNs-LIT, variables "sexage" (sex combined) "edges" (pairs RSNs) introduced. FC calculated as Pearson correlation between RSNs. LMEM revealed no effect sexage or The edges, but there interaction sexage, edges. Interaction i) males ii) edges male vision, memory, motor action. conclude that day should be taken into account when designing, analyzing, interpreting imaging studies rodents.
Язык: Английский
Процитировано
1
Minerva Medica, Год журнала: 2024, Номер 115(2)
Опубликована: Май 1, 2024
Melatonin, a hormone produced by the pineal gland, regulates sleep-wake cycle and is effective in restoring biological rhythms. Prolonged-release melatonin (PRM) designed to mimic natural physiological pattern of release. In circadian medicine, PRM can be used treat sleep rhythm disorders, as well numerous organic diseases associated with disorders.
Язык: Английский
Процитировано
1
Medical Science Monitor, Год журнала: 2024, Номер 30
Опубликована: Апрель 23, 2024
Maladaptive daydreaming has been recently identified as a mental disorder and significantly relates to high levels of attentional absorption.As form spontaneous self-generated process, can lead the disintegration attention from immediate external environment.In extreme cases, patients may develop maladaptive comorbid with dissociation, experiencing excessive compulsive immersion into vivid intricate fantasized daydreams, leading intense emotional involvement kinesthetic movements.The examination dissociative alterations frequently occurs within framework complex cognitive processes.While dissociation be neurological psychological dysfunction integration, transient occurrences such momentary signify dynamic interplay between division orientation sensory cortex.Furthermore, previous studies have recorded interactivity stimuli-driven positive-deflected wave 3 active suppression distractor positivity related posterior-contralateral negative-deflected 2. In this context, during auditory visual mismatch negativity 1, cortex interact orientation.Additionally, task-relevant stimuli play crucial role in predicting since cortices share cerebral correlates fluctuations imagery.The investigation associated extended mindfulness.This article aims review neurophysiology states, which help resolution for psychopathology.
Язык: Английский
Процитировано
1
Life, Год журнала: 2024, Номер 14(10), С. 1225 - 1225
Опубликована: Сен. 25, 2024
Background: The causal connection between morning diurnal preference and psychiatric disorders remains enigmatic. Using bidirectional two-sample Mendelian randomization (MR), we aim to explore the potential associations seven prominent disorders. Methods: MR is a genetic epidemiological method that leverages variants as instrumental variables infer exposures outcomes. We obtained data from genome-wide association study (GWAS) datasets identified 252,287 individuals people. Psychiatric disorder were sourced FinnGen consortium R9 dataset. Our primary analysis used inverse-variance weighted (IVW) approach evaluate overall effect by combining estimates each variant. Addition analyses, including median, MR-Egger regression, mode, simple mode techniques conducted ensure robustness. Results: Being person related reduced odds of multiple disorders, depression or dysthymia (OR: 0.93, 95% CI: 0.88, 0.999), anxiety 0.90, 0.84, 0.96), self-harming behaviors 0.87, 0.76, 0.99), substance-use 0.81, 0.71, 0.93), alcohol dependence 0.82, 0.73, 0.92), use 0.85, 0.94), acute intoxication 0.86, schizophrenia 0.77, 0.65, delusion 0.80, 0.70, 0.92). Alcohol 0.97, 0.94, 0.999) 0.96, 0.99) also lower preference. Conclusions: provides evidence being protective factor for various perspective. results provide insights targeted interventions improve mental wellbeing.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 5, 2024
Robust connections have been identified between the pathophysiology of mental disorders and functioning circadian system. The overarching objective this study was to investigate potential for rhythms be leveraged therapeutics in disorders.
Язык: Английский
Процитировано
1
Melatonin Research, Год журнала: 2023, Номер 6(1), С. 51 - 58
Опубликована: Фев. 28, 2023
The prevalence of mental illnesses has significantly increased globally in recent decades due to multifactorial causes. Of these, schizophrenia and bipolar disorder, their high incidence associated disability, stand out. However, the effective treatments on these disorders are lagged behind incidence. Melatonin, as an essential molecule regulation sleep-wake rhythm naturally occurring antioxidant, only received attention for treatment such psychiatric relation its circadian regulation, but overwhelming role a regulator oxidative stress that facilitates amelioration neuronal damage not been addressed this respect. In communication, novel aspects melatonin have discussed. We provide necessary literature justify beneficial roles mechanisms treat disorder. These include enhances reticulum stress, potentiates unfolded protein response, increases endoplasmic synthesis facilitate autophagy even suppresses apoptosis. This process involves expected organelles is more complex cohesion includes mitochondria, well-known target melatonin, which reinforces robustness our hypothesis, i.e., prevents development aggregates abnormal structures typically observed brain damage. Its documented capacity need improve efficiency growing population afflicted by basis hypothesis support disorders.
Язык: Английский
Процитировано
2
Children, Год журнала: 2023, Номер 10(7), С. 1121 - 1121
Опубликована: Июнь 28, 2023
Only a few studies assessing the sleep effects of low doses melatonin (aMT) have been performed in past, most them adults, and only one subjects with attention-deficit/hyperactivity disorder (ADHD). The aim this study was to provide evidence changes induced by aMT as 1 mg pattern pediatric patients ADHD under treatment methylphenidate (MPH).
Язык: Английский
Процитировано
2