Chemical Analysis and Alkaloid Intake for Kratom Products Available in the United States

Drug Testing and Analysis, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

ABSTRACT Previously, we used ecological momentary assessment (EMA) to evaluate motivations and temporal patterns of kratom use for 15 days among US adult consumers ( N = 357). Here present the content analyses products during that nationwide study, with quantification 10 alkaloids. The samples 341) were primarily whole‐leaf products, not extracts, similar each other in their alkaloid composition, closely matching chromatographic‐mass spectrometry fingerprint expected Mitragyna speciosa leaf material. We found no evidence adulteration illicit or prescription drugs. With participants' self‐reported data on amount per use, calculated mitragynine intake use: mean 31.3 mg median 25.4 (range 2.0–205.9 mg). frequency, day, it ranged from 78.3 134.6 (mean) 50.8 101.6 (median). This is most comprehensive analysis date. coupling self‐report product sample‐analysis quantify daily foundational designing controlled clinical trials healthy volunteers. These findings products' chemical composition consumption can also inform clinicians, policymakers, consumers, particularly

Язык: Английский

The rise of novel, semi‐synthetic 7‐hydroxymitragnine products

Addiction, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Язык: Английский