Seminars in Arthritis and Rheumatism, Год журнала: 2024, Номер unknown, С. 152581 - 152581
Опубликована: Ноя. 1, 2024
International Immunopharmacology, Год журнала: 2024, Номер 131, С. 111850 - 111850
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
6
International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113357 - 113357
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3520 - 3520
Опубликована: Апрель 9, 2025
Cardio-rheumatology is an evolving and interdisciplinary field lying at the intersection of rheumatology cardiovascular medicine that recognizes individuals with autoimmune inflammatory rheumatic complications have a much higher likelihood developing diseases (CVDs). Inflammasomes are multiprotein complexes stimulated by immune system after detection pathogens or cellular injury. undergo two-stage activation process initiated nuclear factor (NF)-κB, subsequently playing crucial role in innate immunity through caspase 1 consequent release proinflammatory cytokines such as IL-18 IL-1β. However, loss control inflammasome can cause humans. Recent studies focused on inflammasomes cascades implicated pathogenesis several diseases. Here, we review activation, its mechanism action, CVD. In particular, describe heart disease, Kawasaki familial Mediterranean fever, ankylosing spondylitis, rheumatoid arthritis exemplars to illustrate pathobiological mechanisms potential for targeting therapeutic benefit.
Язык: Английский
Процитировано
0
Current Opinion in Immunology, Год журнала: 2025, Номер 94, С. 102561 - 102561
Опубликована: Май 12, 2025
Язык: Английский
Процитировано
0
Cytokine, Год журнала: 2024, Номер 184, С. 156796 - 156796
Опубликована: Ноя. 1, 2024
Rheumatoid arthritis (RA) remains a devastating autoimmune disease characterized by joint damage, inflammation, and disability. This study investigates the function of lymphocyte antigen 96 (LY96) in inflammatory response RA explores its regulatory mechanism.
Язык: Английский
Процитировано
1
Acta Biomedica Scientifica (East Siberian Biomedical Journal), Год журнала: 2024, Номер 9(4), С. 215 - 220
Опубликована: Сен. 28, 2024
To the present day, many links in pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results its therapy. The aim. study cells involved immune reactions and tryptophan metabolites joint capsule arthritis. Materials methods. experiments were carried out on 40 Wistar rats. Rheumatoid was induced by intraperitoneal injection a solution type 2 collagen (Chondrex Inc., USA) incomplete Freund’s adjuvant. On days 7, 14 21, content tryptophan, kynurenine, 3-hydrokenurinine, L-5-hydrotryptophan determined using high-performance liquid chromatography. Cells with CD3, CD20 CD68 tissues studied at same time streptavidin-biotin-peroxidase method. We used enzyme-linked immunosorbent method determine antibodies citrulline-containing peptide. Statistical analysis performed Jamovi, version 2.3 software. Results. carrying markers high experimental In tissues, along kynurenine pathway also increases concentration serotonin decreases. Direct positive correlations differential clusters negative established. Conclusions. – play an important role
Язык: Английский
Процитировано
0
Exploration of Immunology, Год журнала: 2024, Номер unknown, С. 358 - 375
Опубликована: Июнь 20, 2024
Rheumatoid arthritis (RA) is a complex autoimmune disorder characterized by spectrum of hypersensitivity reactions, encompassing Type II, III, and IV responses. Firstly, RA marked II reactions driven autoantibodies, such as rheumatoid factor (RF) anti-(cyclic) citrullinated protein antibodies (ACPAs). These autoantibodies serve not only serological markers for but also actively participate in inflammation, bone erosion, clinical outcomes, with concurrent activation the complement system involving C1q, C3, C5 components specifically linked to progression damage. Secondly, exhibits traits III hypersensitivity, formation immune complexes inciting inflammatory reactions. Immunoglobulin G (IgG) like RF ACPA play pivotal roles ensuing demonstrates propelled CD4+ T cells, helper 1 (Th1) Th17 subsets. Th1 cells release interferon (IFN)-γ, promoting proinflammatory cytokines, while secrete IL-17, IL-22, granulocyte-macrophage colony-stimulating (GM-CSF), contributing synovial cartilage damage, angiogenesis. concurrently features hypersensitivity. It crucial comprehend presence interplay responses specific cell subsets create precise efficient therapeutic approaches management this incapacitating condition. Thus, review, we aim provide comprehensive overview RA.
Язык: Английский
Процитировано
0
Advances in Rheumatology, Год журнала: 2024, Номер 64(1)
Опубликована: Сен. 9, 2024
Abstract Backgrounds Progranulin (PGRN) is a growth factor-like molecule with diverse roles in homeostatic and pathogenic processes including the control of immune inflammatory responses. Pathogenic inflammation hallmark systemic lupus erythematosus (SLE) elevated serum levels PGRN has been evaluated as biomarker disease activity SLE. However, role SLE not fully investigated. This study aimed to determine potential involvements Methods Wild type (WT) knockout (PGRN -/- ) C57BL/6 mice received intraperitoneal injection pristane for induction murine model Sera were collected every biweekly anti-dsDNA antibody, IgG, factors measured. Mice sacrificed 5 months later renal lesions, well proportions T cell subtypes spleen analyzed. Results Following exposure pristane, generated significantly lower antibody IgG relative WT mice. mouse kidneys had less collagen deposition compared after injection. Conclusion The results indicate that participates response damage induced models, suggesting mediates onset
Язык: Английский
Процитировано
0
Seminars in Arthritis and Rheumatism, Год журнала: 2024, Номер unknown, С. 152581 - 152581
Опубликована: Ноя. 1, 2024
Процитировано
0