Inorganics,
Год журнала:
2024,
Номер
12(11), С. 283 - 283
Опубликована: Окт. 30, 2024
A
number
of
N-heterocyclic
carbene–silver
compounds
(NHCs)AgX
were
tested
in
the
direct
carboxylation
terminal
alkynes
using
carbon
dioxide
as
C1
feedstock.
The
reactions
proceed
at
a
pressure
1
atm
CO2
room
temperature,
presence
Cs2CO3,
and
silver–NHC
complexes
catalysts.
Thus,
phenylacetylene
several
are
converted
to
corresponding
propiolic
acids
good
high
conversions.
activity
catalysts
is
strongly
influenced
by
substituents
on
NHC
backbone
nature
counterion.
Specifically,
most
active
compound
exhibits
iodide
counterion
stabilized
benzimidazole
derivative.
After
24
h
reaction,
quantitative
conversion
obtained
utilizing
DMF
solvent
substrate.
Drug Development Research,
Год журнала:
2021,
Номер
82(7), С. 907 - 926
Опубликована: Май 12, 2021
Abstract
Because
of
the
continuous
need
for
efficient
therapeutic
agents
against
various
kinds
cancers
and
infectious
diseases,
pharmaceutical
industry
has
to
find
new
candidates
strategies
develop
novel
drugs.
They
increasingly
use
computational
tools
in
R&D
stages
screening
extensive
sets
drug
before
starting
pre‐clinical
clinical
trials.
N‐Heterocyclic
carbenes
(NHCs)
can
be
evaluated
as
good
because
they
offer
both
anti‐cancer
anti‐inflammatory
features
with
their
general
low‐toxicity
profiles.
To
date,
different
NHCs
(Cu,
Co,
Ni,
Au,
Ag,
Ru,
etc.)
have
been
synthesized
uses
shown.
Here,
we
reviewed
recent
studies
focused
on
Ag(I)‐NHC
complexes
activities.
Also,
existing
examples
usage
density
functional
theory
structure–activity
relationship
evaluated.
