Cellular Signalling, Год журнала: 2023, Номер 115, С. 111017 - 111017
Опубликована: Дек. 18, 2023
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(4), С. 455 - 455
Опубликована: Апрель 12, 2024
Diabetic kidney disease (DKD) is the principal culprit behind chronic (CKD), ultimately developing end-stage renal (ESRD) and necessitating costly dialysis or transplantation. The limited therapeutic efficiency among individuals with DKD a result of our finite understanding its pathogenesis. complex interactions between various factors. Oxidative stress fundamental factor that can establish link hyperglycemia vascular complications frequently encountered in diabetes, particularly DKD. It crucial to recognize essential integral role oxidative development diabetic complications, Hyperglycemia primary trigger an upsurge production reactive oxygen species (ROS), sparking stress. main endogenous sources ROS include mitochondrial production, NADPH oxidases (Nox), uncoupled endothelial nitric oxide synthase (eNOS), xanthine oxidase (XO), cytochrome P450 (CYP450), lipoxygenase. Under persistent high glucose levels, immune cells, complement system, advanced glycation end products (AGEs), protein kinase C (PKC), polyol pathway, hexosamine pathway are activated. Consequently, oxidant–antioxidant balance within body disrupted, which triggers series reactions downstream pathways, including phosphoinositide 3-kinase/protein B (PI3K/Akt), transforming growth beta/p38-mitogen-activated (TGF-β/p38-MAPK), nuclear kappa (NF-κB), adenosine monophosphate-activated (AMPK), Janus kinase/signal transducer activator transcription (JAK/STAT) signaling. might persist even if strict control achieved, be attributed epigenetic modifications. treatment remains unresolved issue. Therefore, reducing intriguing target. clinical trials have shown bardoxolone methyl, erythroid 2-related 2 (Nrf2) activator, blood glucose-lowering drugs, such as sodium-glucose cotransporter inhibitors, glucagon-like peptide-1 receptor agonists effectively slow down progression by Other antioxidants, vitamins, lipoic acid, Nox regulators, present promising option for In this review, we conduct thorough assessment both preclinical studies current findings from focus on targeted interventions aimed at manipulating these pathways. We aim provide comprehensive overview state research area identify key areas future exploration.
Язык: Английский
Процитировано
48
APOPTOSIS, Год журнала: 2025, Номер unknown
Опубликована: Янв. 4, 2025
Язык: Английский
Процитировано
3
Frontiers in Endocrinology, Год журнала: 2025, Номер 15
Опубликована: Янв. 13, 2025
Background Type 2 diabetes (T2D) has become a significant global health threat, yet its precise causes and mechanisms remain unclear. This study aims to identify gene expression patterns specific T2D pancreatic islet cells explore the potential role of stellate (PSCs) in progression through regulatory networks involving lncRNA-mRNA interactions. Methods In this study, we screened for upregulated genes samples using bulk sequencing (bulkseq) datasets mapped these profiles onto three single-cell RNA (scRNAseq) datasets. The identified T2D-specific features were further validated an additional scRNAseq dataset, T1D bulkseq dataset. To investigate networks, analyzed interactions within peripheral blood mononuclear cell (PBMC) data. Results Our analysis panel—COL1A2, VCAN, SULF1—that was consistently samples. Expression panel strongly associated with activation (PSCs), suggesting unique signature characterized by COL1A2 hi /VCAN /SULF1 PSCs. exclusive not observed 1 (T1D) samples, indicating distinct activated PSCs progression. Furthermore, six long non-coding RNAs (lncRNAs) that potentially interact These lncRNAs network, they may modulate immune responses reshape microenvironment T2D. Discussion findings highlight immune-regulatory suggest PSC-related could serve as novel therapeutic targets treatment. research provides insights into modulator progression, paving way innovative treatment strategies.
Язык: Английский
Процитировано
1
Cell Biochemistry and Function, Год журнала: 2024, Номер 42(2)
Опубликована: Март 1, 2024
Abstract Over the past decade, prevalence of diabetes has increased significantly worldwide, leading to an increase in vascular complications (VCD), such as diabetic cardiomyopathy (DCM), nephropathy (DN), and retinopathy (DR). Noncoding RNAs (ncRNAs), microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), play a key role cellular processes, including pathophysiology VCD via pyroptosis. ncRNAs (e.g., miR‐17, lnc‐MEG3, lnc‐KCNQ1OT1) can regulate pyroptosis pancreatic β cells. Some are involved progression. For example, miR‐21, lnc‐KCNQ1OT1, lnc‐GAS5, lnc‐MALAT1 were reported DN DCM, lnc‐MIAT was identified DCM DR. Herein, this review aimed summarize recent research findings related ncRNAs‐mediated at onset progression VCD.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Апрель 25, 2025
Diabetic kidney disease (DKD) is one of the major complications diabetes, and its pathological progression closely associated with lipid metabolic reprogramming. Under diabetic conditions, renal cells undergo significant abnormalities, including increased uptake, impaired fatty acid oxidation, disrupted cholesterol efflux, enhanced catabolism, as adaptive responses to stress. These changes result in accumulation lipids such free acids, diacylglycerol, ceramides, leading lipotoxicity that triggers inflammation fibrosis. Hypoxia DKD microenvironment suppresses oxidation promotes synthesis through HIF-1α pathway, while chronic exacerbates disturbances via inflammatory cytokines, inflammasomes, macrophage polarization. Targeting metabolism represents a promising therapeutic strategy for alleviating DKD; however, further clinical translational studies are warranted validate efficacy safety these approaches.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Май 21, 2025
Amyotrophic lateral sclerosis (ALS) is a multifactorial motor neuron (MN) disease, characterized by several cellular dysfunctions, many of which are shared different neurodegenerative diseases. Here, we investigated whether stressful lifestyle might exacerbate the altered mechanisms and affect disease progression in ALS-predisposed conditions. To model stress vivo, SOD1G93A mice underwent chronic unpredicted mild protocol. This resulted significant impairment body weight gain performance, gender-specific manner. Moreover, gene expression Col1a1, Col1a2 Il6 was strongly dysregulated cortex and/or spinal cord stressed mice. assess direct impact on MNs, NSC-34 hSOD1G93A cells oxygen glucose deprivation. Compared to hSOD1WT, mutated MNs exhibited reduced capacity cope with stress. By performing expression, protein-protein interaction, ontology pathway enrichment analyses, also revealed pivotal role PI3K/Akt focal adhesion pathways (triggered Gsk3b, Il6, Igf1 collagen) mediating response. Similar results were observed human iPSCs-derived TARDBPG298S MNs. In conclusion, our suggest that play crucial response across models: study paves way for novel therapeutic targets highlights relevance healthy lifestyle.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115818 - 115818
Опубликована: Ноя. 6, 2023
Diabetic nephropathy (DN) is a prevalent chronic microvascular complication associated with diabetes mellitus and represents major cause of kidney disease renal failure. Current treatment strategies for DN primarily focus on symptom alleviation, lacking effective approaches to halt or reverse progression. Circular RNA (circRNA), characterized by closed-loop structure, has emerged as novel non-coding regulator gene expression, attributed its conservation, stability, specificity, multifunctionality. Dysregulation circRNA expression closely progression, whereby impacts cell injury modulating cycle, differentiation, death, well influencing the release inflammatory factors stromal fibronectin expression. Consequently, considered predictive biomarker potential therapeutic target DN. This review provides an overview latest research progress in classification, functions, monitoring methods, databases related circRNA. The paper focuses elucidating impact underlying mechanisms cells under diabetic conditions, aiming offer insights into prevention, diagnosis,
Язык: Английский
Процитировано
6
International Journal of Molecular Medicine, Год журнала: 2024, Номер 53(5)
Опубликована: Март 21, 2024
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These have been implicated in initiation progression multiple human diseases, ranging from cancer to inflammatory metabolic including diabetes mellitus its vascular complications. The present article aimed review current knowledge on biogenesis functions circRNAs, well their role cell processes associated with diabetic nephropathy. In addition, novel potential interactions between circRNAs expressed renal cells exposed high‑glucose concentrations transcription factors c‑Jun c‑Fos reported.
Язык: Английский
Процитировано
1
Diabetic Nephropathy, Год журнала: 2023, Номер 3(3), С. 58 - 67
Опубликована: Сен. 1, 2023
Abstract Diabetic nephropathy (DN) is a chronic kidney disease that occurs in patients with diabetic mellitus. In the United States of America, one three people diabetes suffers from DN. Globally, DN 30%–40% diagnosed diabetes. Circular ribonucleic acids (circRNAs) are non-coding, closed-loop RNAs play critical roles regulating gene expression by sponging microRNAs (miRNAs). Recent studies have implicated circRNAs regulation various diseases including We delineate circRNA biological networks evidence gleaned clinical studies. Further, we elucidate circRNA-associated signal transduction pathways pathogenesis Taken together, this will facilitate discovery novel and/or miRNA biomarkers for diagnostic therapeutic intervention
Язык: Английский
Процитировано
2
Molecular Biology, Год журнала: 2024, Номер 58(6), С. 1241 - 1249
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0