Enzymatic production of chitooligosaccharides with high degree of polymerisation and their potential application to soy sauce preservation

Enzyme and Microbial Technology, Год журнала: 2025, Номер 186, С. 110608 - 110608

Опубликована: Фев. 17, 2025

Язык: Английский

An Oral H₂S Responsive Cu_5.4O Nanozyme Platform with Strong ROS/H₂S Scavenging Capacity for the Treatment of Colitis

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 17(1), С. 617 - 631

Опубликована: Дек. 25, 2024

Inflammatory bowel disease involves excess reactive oxygen species (ROS) and hydrogen sulfide (H2S) at inflammatory sites. Nanozyme-mediated ROS H2S scavenging therapy is promising for colitis treatment. Here, we synthesized a multiple Cu5.4O nanoparticle first explored its capacity. Chitosan oligosaccharide modified with alpha-lipoic acid was coated on the nanoparticles to further enhance Furthermore, calcium alginate surface develop an oral nanoplatform (Cu5.4O@SAG) possessing dual-pH/H2S-responsive release characteristics. Importantly, Cu5.4O@SAG exhibited enrichment colonic inflammation site relieved index, containing recovery of colon length, spleen liver body weight, as well cell infiltration. In vivo in vitro experiments revealed dual capacities nanoplatform. Additionally, regulated tight junctions, mucus layers, gut microbiota, which accompanied by downregulation cytokines. Notably, also had excellent biocompatibility. conclusion, this multiple-scavenging nanozyme platform provides new safe paradigm development nanozymes

Язык: Английский

Anti-inflammatory and antioxidant succinyl-chitosan oligosaccharide protects human epidermal cell and mouse skin against ultraviolet B-induced photodamage

Carbohydrate Polymers, Год журнала: 2024, Номер 351, С. 123102 - 123102

Опубликована: Дек. 3, 2024

Язык: Английский