Bioinformatics and experimental insights into F2RL1 as a key biomarker in cervical cancer diagnosis and prognosis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 12, 2025

Cervical cancer(CCa) remains a significant global public health concern, with early diagnosis and treatment being crucial. Moreover, the molecular mechanisms underlying its pathogenesis remain incompletely elucidated. F2RL1 is closely associated various tumors. However, relationship CCa poorly understood. We accessed data from 309 patients diagnosed TCGA database. The Limma package facilitated differential expression analysis to identify differentially expressed mRNAs (DEmRNAs). Survival ROC were conducted via XIANTAO Immune-related genes identified F2RL1-related through ImmPort database analysis. Functional enrichment was carried out using GO, KEGG, GSEA. gathered cervical cells serum participants test for HPV TCT, then used qPCR check levels of mRNA expression. also verified protein WB ELISA techniques. Our investigation has unveiled fascinating discovery—the in tissues are notably elevated when compared normal tissues, showcasing intriguing variations among pathological types. presence high linked reduce Overall (OS), Progression Free Interval (PFI), (PFS). rocked an AUC 0.996. Furthermore, significantly impact different N stages, tissue types, statuses, racial groups, allowing us develop predictive model. Additionally, we 43 immune-related genes. Enrichment highlighting their association pathways related cell movement T activation. Through analysis, discovered inverse proportion between infiltration most immune cells, particularly TFH cytotoxic suggesting potential link evasion CCa. Molecular biology experiments confirmed increase exfoliated serum. research uncovers detection significance correlation first time. strongly progression could serve as biomarker prognosis patients.

Язык: Английский

Emerging role of ferroptosis in ultraviolet radiation-driven skin photoaging: a narrative review

Photochemical & Photobiological Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle

Pflügers Archiv - European Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Язык: Английский