The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies

Reproductive Toxicology, Год журнала: 2025, Номер 132, С. 108830 - 108830

Опубликована: Янв. 6, 2025

Язык: Английский

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Selenium‐ and zinc‐biofortified bean sprouts improve cognitive dysfunction in aging mice by reducing oxidative stress

Journal of Food Science, Год журнала: 2025, Номер 90(3)

Опубликована: Март 1, 2025

Currently, age-related diseases are a serious global health problem. In this study, selenium- and zinc-biofortified bean sprouts (ZSB) were cultivated, the intervention effect on cognitive dysfunction was explored in aging mice model established by combining AlCl3 d-galactose treatment. The results showed that compared with group, ZSB could decrease accumulation of Al increase Zn Se mice. levels serum superoxide dismutase, glutathione, glutathione peroxidase liver acetylcholine brain significantly increased (p < 0.05) after treatments biofortified sprouts. Additionally, treatment reduced level lipid peroxidation inhibited deposition Aβ1-40 activity acetylcholinesterase. It also abundance lactic acid bacteria cecum inhibit proliferation Escherichia coli, then content short-chain fatty acids increased. More importantly, hippocampal neuron damage reversed, correct rate spontaneous behavior alternations 35% Overall, can effectively slow down process through variety ways, which provide countermeasures for delaying aging.

Язык: Английский

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Role of Zinc Homeostasis in the Prevention of Prostate Diseases

Journal of Trace Elements in Medicine and Biology, Год журнала: 2025, Номер 88, С. 127605 - 127605

Опубликована: Янв. 22, 2025

Язык: Английский

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Palliative Effect of Combined Application of Zinc and Selenium on Reproductive Injury Induced by Tripterygium Glycosides in Male Rats

Biological Trace Element Research, Год журнала: 2024, Номер 202(11), С. 5081 - 5093

Опубликована: Янв. 8, 2024

Язык: Английский

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Zinc Deficiency Leads to Reproductive Impairment in Male Mice Through Imbalance of Zinc Homeostasis and Inflammatory Response

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Язык: Английский

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Zinc sulphate alleviates olanzapine-induced testicular oxidative stress and alters trace elements in male rats

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 7, 2024

Male infertility is a complex and multifactorial clinical condition affecting large population attributed to various factors, including perturbation in oxidative stress the level of essential trace elements. Oxidative insults exert multiple issues related reproductive health, male infertility, decreased sperm motility, DNA damage, an increased susceptibility genetic disorders. Besides chemical toxins food allergens junk items, many drugs can also lead fertility. Olanzapine, general antipsychotic drug, has been reported induce A great deal literature entails that zinc alleviate stress-related complications This study investigates potential protective effects sulphate on olanzapine-induced infertility. In present study, there were four treatment groups (n = 6) Group 1 as control (without any treatment); 2 treated with olanzapine (10 mg/kg) orally daily for six weeks; 3 4 50mg/kg 100 mg/kg respectively pre-exposed (10mg/kg) weeks. After completion treatment, biochemical analysis serum tissue samples demonstrated group had compromised levels antioxidant parameters (SOD, CAT GSH) well elevated (GSSG, MDA NO). However, ZnSO4 corrected all these dose-dependent way 4. Other health indicators, like taurine, enzyme Q10, phosphatidylcholine, ascorbic acid, vitamin E, observed improve supplementation ZnSO4. Intriguingly, fertility (sperm count testosterone) found significantly enhanced abnormalities both combination groups. The histological evaluation testis section agreed analysis. Therefore, strongly advocates Zn ameliorate significant extent.

Язык: Английский

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Changes in antioxidants and nutritional properties during germination of soybean

Journal of King Saud University - Science, Год журнала: 2024, Номер 36(11), С. 103527 - 103527

Опубликована: Ноя. 6, 2024

Язык: Английский

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