International Journal of Sexual and Reproductive Health Care,
Год журнала:
2024,
Номер
7(1), С. 028 - 032
Опубликована: Апрель 30, 2024
Autophagy
is
a
highly
controlled
cellular
mechanism
that
maintains
homeostasis
by
degrading
and
recycling
components.
In
recent
years,
there
has
been
greater
concentration
on
understanding
the
role
of
autophagy
in
male
reproductive
system.
This
review
addresses
potential
importance
many
aspects
physiology,
such
as
spermatogenesis,
sperm
maturation,
testicular
function.
The
fertility,
quality,
response
to
environmental
stressors
explored.
Insights
into
molecular
mechanisms
driving
cells
cover
groundwork
for
future
research
targeted
at
complex
relationship
between
health.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2600 - 2600
Опубликована: Фев. 23, 2024
Free
radicals
(FRs)
are
unstable
molecules
that
cause
reactive
stress
(RS),
an
imbalance
between
oxygen
and
nitrogen
species
in
the
body
its
ability
to
neutralize
them.
These
generated
by
both
internal
external
factors
can
damage
cellular
lipids,
proteins,
DNA.
Antioxidants
prevent
or
slow
down
oxidation
process
interrupting
transfer
of
electrons
substances
agents.
This
is
particularly
important
at
level
because
reactions
lead
formation
FR
contribute
various
diseases.
As
we
age,
RS
accumulates
leads
organ
dysfunction
age-related
disorders.
Polyphenols;
vitamins
A,
C,
E;
selenoproteins
possess
antioxidant
properties
may
have
a
role
preventing
treating
certain
human
diseases
associated
with
RS.
In
this
review,
explore
current
evidence
on
potential
benefits
dietary
supplementation
investigate
intricate
connection
SIRT1,
crucial
regulator
aging
longevity;
transcription
factor
NRF2;
polyphenols,
vitamins,
selenium.
Finally,
discuss
positive
effects
molecules,
such
as
reducing
RS,
their
slowing
several
Materials,
Год журнала:
2024,
Номер
17(15), С. 3748 - 3748
Опубликована: Июль 29, 2024
In
recent
years,
selenium
nanoparticles
(SeNPs)
have
attracted
expanding
consideration,
particularly
in
the
nanotechnology
field.
This
element
participates
important
biological
processes,
such
as
antioxidant
defense,
immune
function,
and
thyroid
hormone
regulation,
protecting
cells
from
oxidative
damage.
Selenium
form
of
nanoscale
particles
has
drawn
attention
for
its
biocompatibility,
bioavailability,
low
toxicity;
thus,
it
found
several
biomedical
applications
diagnosis,
treatment,
monitoring.
Green
methods
SeNP
synthesis
using
plant
extracts
are
considered
to
be
single-step,
inexpensive,
eco-friendly
processes.
Besides
acting
natural
reductants,
compounds
can
also
serve
capping
agents,
stabilizing
size
contributing
enhanced
properties
SeNPs.
brief
overview
presents
developments
this
area,
focusing
on
conditions
characteristics
obtained
Pharmacological Research,
Год журнала:
2025,
Номер
216, С. 107783 - 107783
Опубликована: Май 15, 2025
Glioma,
the
most
prevalent
primary
intracranial
tumor,
presents
significant
clinical
treatment
challenges
due
to
its
high
invasiveness
and
therapeutic
resistance.
Therefore,
development
of
a
targeted
agent
that
is
both
highly
effective
low
in
toxicity
crucial.
In
this
research,
we
aimed
design
bionic
mesoporous
selenium
nanoparticle
(ACMLMSeP)
functionalized
with
paclitaxel
Ang-2
for
nasal
administration
as
approach
glioma.
Nasal
facilitates
direct
delivery
drugs
brain
through
olfactory
nerve,
thereby
circumventing
protective
mechanisms
blood-brain
barrier.
Mesoporous
(MSe)
significantly
enhances
loading
capacity
insoluble
while
improving
their
water
solubility.
The
functionalization
MSe
enables
slow
drug
release
accumulation.
Moreover,
accumulated
nano-selenium
promotes
reactive
oxygen
species
(ROS)
production,
induces
autophagy,
synergizes
accelerate
apoptosis
tumor
cells.
Analysis
using
Transmission
Electron
Microscopy
(TEM)
images
Dynamic
Light
Scattering
(DLS)
indicated
ACMLMSe
has
an
average
particle
size
roughly
135
nm.
Results
from
vitro
assessments
ACMLMSeP
sustained
drug,
reaching
total
rate
74.96
±
2.34
%
within
24
h.
Cellular
uptake
studies
vivo
imaging
showed
strong
targeting
capabilities
nanoparticles.
Furthermore,
results
obtained
MTT
assays,
flow
cytometry
analysis,
immunofluorescence
staining,
antitumor
evaluations
collectively
revealed
effectively
inhibited
proliferation
promoting
C6
summary,
these
experimental
findings
clearly
suggest
may
serve
promising
biomimetic
nanosystem
RSC Advances,
Год журнала:
2024,
Номер
14(1), С. 640 - 649
Опубликована: Янв. 1, 2024
Carbon-coated
selenium
(C–Se)
nanoparticles
were
prepared
to
perform
roles
in
photothermal
therapy
on
choriocarcinoma
cells
by
inducing
ROS
generation
and
apoptosis
under
near-infrared
irradiation.
Endocrine Regulations,
Год журнала:
2024,
Номер
58(1), С. 233 - 241
Опубликована: Янв. 1, 2024
Abstract
The
present
minireview
traces
the
road
leading
to
discovery
of
selenium,
formerly
appointed
as
a
toxic
element
that
became
later
bioelement,
which
is
necessary
for
proper
functioning
living
organisms.
Selenium
occurs
in
human
and
animal
bodies
either
form
seleno-Lcysteine
or
its
dimeric
seleno-L-cystine
crucial
component
selenoenzymes
selenoproteins.
atom
represents
an
integral
enzyme
active
site
different
forms
glutathione
peroxidase,
catalyzes
conversion
hydrogen
peroxide
organic
hydroperoxides
into
water
corresponding
alcohols.
A
revolutionary
breakthrough
field
endocrinology
came
with
identification
iodothyronine
deiodinase
selenoenzymes,
play
important
role
metabolism
thyroid
hormone.
selenium
immune
function
autoimmune
thyropathies
might
be
associated
deficiency
are
reported
discussed.
This
also
brings
forward
novel
directions
organoselenium
compounds
nanoparticles
cancer
therapy.
Based
on
update
available
literature
author’s
experimental
experience,
can
devoted
clinicians
medical
students.
SAR Journal of Medical Biochemistry,
Год журнала:
2024,
Номер
5(03), С. 16 - 21
Опубликована: Май 3, 2024
Cadmium,
an
environmental
pollutant
prevalent
in
various
industrial
surroundings,
poses
a
substantial
risk
to
male
fertility.
This
review
explores
the
complex
mechanisms
through
which
cadmium
exerts
its
toxic
effects
on
testis.
The
testis,
primary
target
for
accumulation,
experiences
structural
and
functional
alterations
that
disrupt
essential
cellular
processes
associated
with
spermatogenesis.
Cadmium-induced
testicular
injury
involves
cascade
of
events,
including
apoptosis,
autophagy,
oxidative
stress,
inflammation,
disruptions
key
signaling
pathways.
These
molecular
changes
collectively
contribute
compromised
function,
leading
impaired
sperm
development
activity.
Understanding
these
is
crucial
delineating
comprehensive
impact
Furthermore,
such
information
opens
avenues
developing
targeted
interventions
aimed
at
mitigating
adverse
exposure
reproductive
function.
aims
consolidate
current
research
findings,
providing
overview
intricate
underlying
cadmium-induced
implications
