Zinc sulphate attenuates metabolic dysfunctions induced by olanzapine via the reduction of insulin resistance, hepatic oxidative stress, and inflammation in albino rats
BMC Pharmacology and Toxicology,
Год журнала:
2025,
Номер
26(1)
Опубликована: Апрель 14, 2025
Abstract
Olanzapine,
an
atypical
antipsychotic
drug,
is
used
to
treat
psychological
diseases.
However,
it’s
use
carries
common
side
effects.
Those
include
weight
gain,
dyslipidemia,
elevated
glucose
levels,
and
disrupted
oxidative
balance.
We
aimed
test
the
effect
of
zinc
coadministration
lessen
metabolic
disturbances,
inflammation
stress
in
a
rat
model.
Four
treatment
groups
(
n
=
6)
were
involved
this
investigation.
Group
1
was
control
group
(received
no
intervention).
2
received
olanzapine
(10
mg/kg,
p.o.;
daily)
for
six
weeks,
whereas
Groups
3
4
50
mg/kg
100
sulphate
(ZnSO
,p.o.;
respectively,
addition
daily).
Following
completion,
showed
increased
levels
markers
(GSSG,
MDA,
NO)
impaired
antioxidant
(CAT,
SOD,
GSH).
Further,
strong
positive
correlation
between
insulin
resistance
index
(HOMA-IR)
IL-6,
TNF-α,
MDA
liver.
Insulin
possible
manifestation
burden
widespread
inflammatory
environment.
In
4,
however,
ZnSO
recovered
each
these
dose-dependent
manner.
Improvements
also
noted
other
homeostatic
markers,
such
as
taurine,
coenzyme
Q10,
ascorbic
acid,
vitamin
E.
Remarkably,
both
combination
groups,
there
significant
improvement
all
indicators
dyslipidemia
(triglycerides,
total
cholesterol)
index.
The
biochemical
study
histological
assessment
liver
slices
agreed
with
results.
Thus,
results
clearly
suggest
that
Zinc
supplementation
can
significantly
improve
stress,
inflammation,
perturbation
(dyslipidemia
resistance),
injury
caused
by
Albino
rats.
Язык: Английский
Effect of olanzapine on testes of adult albino rats and the possible role of granulocyte colony stimulating factor versus umbelliferone light and electron microscopic study
Ultrastructural Pathology,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Апрель 24, 2025
Olanzapine
(OLZ)
is
one
of
atypical
antipsychotic
drugs
(second
generation)
used
for
treating
schizophrenia,
manic,
and
mixed
episodes
bipolar
disorder.
Continuous
evaluation
its
effects
necessary,
there
a
need
to
explore
alternative
natural
products
as
G-CSF
UMB
manage
potential
side
effects.
This
research
designed
mitigate
the
drugs'
adverse
through
biochemical
analyses,
light
electron
microscopic
studies.
Fifty-six
rats
were
divided
into
five
groups:
Control,
OLZ,
G-CSF,
UMB,
Recovery
groups.
End
body
testicular
weights,
serum
testosterone,
MDA
levels,
seminal
analysis
recorded.
Testicular
specimens
processed
evaluate
histological
structure,
PCNA,
CD34
immune
expression.
Morphometric
statistical
analyses
also
performed.
OLZ
group
exhibited
distorted
significant
increase
in
end
decline
weight,
level
testosterone
level,
MDA,
parameters.
Furthermore,
disturbed
histoarchitecture,
reduction
elevation
immunoreaction
observed.
These
alterations
partially
attenuated
by
therapy,
whereas
significantly
improved
all
In
conclusion,
lesser
degree
appeared
be
superior
therapeutic
options
attenuating
oxidative
stress
restoring
intact
structure
Язык: Английский