Journal of Applied Toxicology, Год журнала: 2024, Номер 44(11), С. 1793 - 1803

Опубликована: Июль 29, 2024

Abstract Food contaminates, such as insecticide, may influence the toxicity of nanoparticles (NPs) to intestine. The present study investigated combined TiO 2 NPs and fipronil male mouse Juvenile mice (8 weeks) were orally exposed 5.74 mg/kg NPs, 2.5 fipronil, or both, once a day, for 5 days. We found that both induced some pathological changes in intestines, accompanying with defective autophagy, but these effects not obviously enhanced after NP co‐exposure. Fipronil promoted Ti accumulation minimal impact on other trace elements NP‐exposed intestines. Metabolomics data revealed exposure altered metabolite profiles two KEGG pathways, namely, ascorbate aldarate metabolism (mmu00053) glutathione (mmu00480), only statistically significantly changed Five metabolites, including 2‐deoxy‐D‐erythro‐pentofuranose 5‐phosphate, 5alpha‐cholestanol, beta‐D‐glucopyranuronic acid, elaidic isopentadecanoic maltotriose, more up‐regulated co‐exposure, whereas trisaccharide xylonolactone down‐regulated by concluded had enhance intestines profiles.

Язык: Английский