Tumor dormancy and relapse: understanding the molecular mechanisms of cancer recurrence

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Фев. 11, 2025

Abstract Cancer recurrence, driven by the phenomenon of tumor dormancy, presents a formidable challenge in oncology. Dormant cancer cells have ability to evade detection and treatment, leading relapse. This review emphasizes urgent need comprehend dormancy its implications for recurrence. Despite notable advancements, significant gaps remain our understanding mechanisms underlying lack reliable biomarkers predicting provides comprehensive analysis cellular, angiogenic, immunological aspects dormancy. It highlights current therapeutic strategies targeting dormant cells, particularly combination therapies immunotherapies, which hold promise preventing By elucidating these proposing innovative research methodologies, this aims deepen ultimately facilitating development more effective recurrence improving patient outcomes.

Язык: Английский

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CCR5 and IL-12 co-expression in CAR T cells improves antitumor efficacy by reprogramming tumor microenvironment in solid tumors

Cancer Immunology Immunotherapy, Год журнала: 2025, Номер 74(2)

Опубликована: Янв. 3, 2025

Язык: Английский

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HER2-positive gastric cancer: from targeted therapy to CAR-T cell therapy

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 13, 2025

Gastric cancer (GC) ranks as the fifth most prevalent on a global scale, with HER2-positive GC representing distinct subtype that exhibits more intricate biological characteristics. Conventional chemotherapy typically restricted efficacy in management of GC. In light incessant advancement molecular targeted therapies, targeting HER2 has emerged promising therapeutic approach for this subtype. The advent antibody-drug conjugates (ADCs) and chimeric antigen receptor T-cell therapy (CAR-T) furnished novel treatment alternatives Nevertheless, owing to pronounced heterogeneity complex tumor microenvironment, drug resistance frequently emerges, thereby substantially influencing effectiveness HER2-targeted therapy. This article comprehensively summarizes deliberates upon strategies well underlying mechanisms.

Язык: Английский

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Cancer-associated fibroblasts and prostate cancer stem cells: crosstalk mechanisms and implications for disease progression

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июль 18, 2024

Graphical Abstract Created using Biorender.com .

Язык: Английский

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Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 28, 2024

Abstract The prognosis for patients with colorectal cancer (CRC) remains worse than expected due to metastasis, recurrence, and resistance chemotherapy. Colorectal stem cells (CRCSCs) play a vital role in tumor chemotherapy resistance. However, there are currently no prognostic markers based on CRCSCs-related genes available clinical use. In this study, single-cell transcriptome sequencing was employed distinguish (CSCs) the CRC microenvironment analyze their properties at level. Subsequently, data from TCGA GEO databases were utilized develop risk model validate its diagnostic performance. Additionally, functional enrichment, immune response, chemotherapeutic drug sensitivity of relevant investigated. Lastly, key gene RPS17 identified as potential marker therapeutic target further comprehensive studies. Our findings provide new insights into treatment offer novel perspectives systematic understanding development.

Язык: Английский

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Unlocking the Therapeutic Potential of Oral Cancer Stem Cell-Derived Exosomes

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1809 - 1809

Опубликована: Авг. 9, 2024

Oral cancer (OC) presents a significant global health burden with rising incidence rates. Despite advancements in diagnosis and treatments, the survival rate for OC patients, particularly those advanced or recurrent disease, remains low at approximately 20%. This poor prognosis is often due to small population of stem cells (CSCs) that are capable self-renewal immune evasion, playing pivotal roles proliferation, tumor initiation, progression, metastasis, therapy resistance. Exosomes, which nano-sized extracellular vesicles (EVs), have emerged as crucial mediators cell-to-cell communication within microenvironment (TME). These carry diverse molecules such DNA, RNA, proteins, lipids, metabolites, influencing various cellular processes. Emerging evidence suggests CSC-derived EVs significantly promote progression metastasis maintain balance between CSCs non-CSCs, vital intracellular TME oral cancer. Recent reports indicate cell-derived (OCSC-EVs) influence stemness, angiogenesis, reoccurrence, drug Understanding OCSC-EVs could improve diagnosis, prognosis, therapy. In this mini-review, we explore OCSC-derived exosomes cancer, examining their potential diagnostic prognostic biomarkers reflect CSC characteristics, delve into therapeutic implications, emphasizing However, despite promising potential, several challenges remain, including need standardize isolation characterization methods elucidate exosome-mediated mechanisms. Thus, comprehensive understanding pave way innovative strategies clinical outcomes patients.

Язык: Английский

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Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies

Cells, Год журнала: 2024, Номер 13(11), С. 958 - 958

Опубликована: Июнь 1, 2024

Autophagy is a globally conserved cellular activity that plays critical role in maintaining homeostasis through the breakdown and recycling of constituents. In recent years, there has been much emphasis given to its complex cancer stem cells (CSCs) cell treatment. This study examines molecular processes support autophagy how it regulated context CSCs Although dual management CSCs, affecting their removal as well maintenance, intricate interaction between several signaling channels control survival death part mechanism not elucidated. Given have development, progression, resistance treatment tumors, imperative comprehend biological activities. are important for biology because they also show tissue regeneration model helps with organoid regeneration. other words, manipulation viable therapeutic approach therapy. Both synthetic natural substances target pathways demonstrated promise improving cell-based therapies eliminating CSCs. Nevertheless, difficulties associated limitations CSC regulation, including mechanisms off-target effects. Thus, regulation offers versatile strategy focusing on enhancing results Therefore, understanding interactions would be essential creating treatments work both regenerative medicine

Язык: Английский

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Microenvironmental Drivers of Glioma Progression

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2108 - 2108

Опубликована: Фев. 27, 2025

Gliomas, particularly glioblastoma (GBM), are among the most challenging brain tumors due to their complex and dynamic tumor microenvironment (TME). The TME plays a pivotal role in progression, immune evasion, resistance therapy through intricate interactions glioma cells, components, neurons, astrocytes, extracellular matrix, blood-brain barrier. Targeting has demonstrated potential, with immunotherapies such as checkpoint inhibitors neoadjuvant therapies enhancing responses. Nonetheless, overcoming immunosuppressive landscape metabolic adaptations continues pose significant challenges. This review explores diverse cellular molecular mechanisms that shape TME. A deeper understanding of these holds promise for providing novel therapeutic opportunities improve treatment outcomes.

Язык: Английский

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Modeling of cancer stem cells and the tumor microenvironment Via NT2/D1 cells to probe pathology and treatment for cancer and beyond

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 24, 2025

Язык: Английский

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Potential Mechanisms for Immunotherapy Resistance in Adult Soft-Tissue Sarcoma

Targeted Oncology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

Soft-tissue sarcomas represent a diverse group of rare malignancies originating from mesenchymal tissue, accounting for less than 1% adult cancers in the USA. With over 13,000 new cases and around 5350 deaths annually, patients with metastatic soft-tissue face limited therapeutic options an estimated median overall survival 18 months. While immunotherapy has demonstrated effectiveness several cancers, its application remains challenging owing to tumors' largely "cold" immunological environment, characterized by low levels tumor-infiltrating lymphocytes lack sarcoma-specific biomarkers. This review examines potential mechanisms underlying resistance sarcomas, including complex interplay between innate adaptive immunity, tumor microenvironment, role immune-related genes. Despite preliminary findings suggesting correlations immune profiles histological subtypes, consistent biomarkers predicting immunotherapeutic responses across sarcoma types are absent. Emerging strategies focus on converting tumors "hot" tumors, enhancing their susceptibility immunologic activation. research is ongoing, personalized treatment approaches may offer hope overcoming inherent heterogeneity seen ultimately aiming improve outcomes affected patients.

Язык: Английский

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