Academia molecular biology and genomics., Год журнала: 2024, Номер 1(1)
Опубликована: Окт. 10, 2024
Язык: Английский
Nature Reviews Bioengineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
1
Biomaterials Advances, Год журнала: 2024, Номер 166, С. 214042 - 214042
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
7
Cells, Год журнала: 2024, Номер 13(12), С. 1045 - 1045
Опубликована: Июнь 17, 2024
Bone/fracture healing is a complex process with different steps and four basic tissue layers being affected: cortical bone, periosteum, fascial surrounding the fracture, bone marrow. Stem cells their derivatives, including embryonic stem cells, induced pluripotent mesenchymal hematopoietic skeletal multipotent can function to artificially introduce highly regenerative into decrepit biological tissues augment at level. are molecularly functionally indistinguishable from standard human tissues. The widespread appeal of cell therapy lies in its potential benefits as therapeutic technology that, if harnessed, be applied clinical settings. This review aims establish molecular pathophysiology current interventions that disrupt or and, finally, considers future direction/therapeutic options related healing.
Язык: Английский
Процитировано
5
Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)
Опубликована: Ноя. 9, 2024
Since wound healing is one of the most important medical challenges and common dressings have not been able to manage this challenge well today, efforts increased achieve an advanced dressing. Mesenchymal stem cells exosomes derived from them shown high potential in regenerating wounds due their immunomodulatory, anti-inflammatory, immunosuppressive, regenerative capacities. However, such as short life these cells, low durability area, stability resulted limitations use for healing. Nowadays, different scaffolds are considered suitable biomaterials These made natural or synthetic polymers promising ideal dressing that does disadvantages dressings. One strategies has attracted much attention today using seeding delivering MSCs exosomes. This combined strategy a enhancing shelf increasing In review, combination with comprehensively discussed.
Язык: Английский
Процитировано
5
Translational Medicine, Год журнала: 2025, Номер 11(6), С. 532 - 545
Опубликована: Янв. 26, 2025
Pathologies associated with impaired bone homeostasis, including osteoporosis, are among the leading diseases in terms of mortality. The development and implementation tissue engineering approaches based on use human mesenchymal stem cells promises to become a highly effective method for their therapy. However, fundamental cellular mechanism, which is diseases, require an additional study. Interactions between osteoblasts osteocytes undoubtedly plays important role maintaining balance processes formation resorption involved pathogenesis certain diseases. For more in-depth understanding various aspects these interactions, representative model needed. In contrast cell cultures obtained from tissues animal models, employment reflects accurately physiological phenotypical nuances bone. possibility creating systems co-cultivation derived application context translational medicine focus this review.
Язык: Английский
Процитировано
0
Biomaterials Advances, Год журнала: 2025, Номер 172, С. 214262 - 214262
Опубликована: Март 2, 2025
Язык: Английский
Процитировано
0
EFORT Open Reviews, Год журнала: 2024, Номер 9(9), С. 837 - 844
Опубликована: Сен. 1, 2024
Advanced therapies are expected to play a crucial role in supporting repair after injury, halting the degeneration of musculoskeletal tissue enable and promote physical activity. Despite advancements, progress developing advanced orthopaedics lags behind specialties like oncology, since innovative regenerative treatment strategies fall short their expectations clinical trials. Researchers should focus on understanding mechanism action investigated target before conducting Strategic research networks needed that not only enhance scientific exchange among like-minded researchers but need include early commercial views, companies venture perspectives, regulatory insights reimbursement perspectives. Only such collaborations essential roadblocks towards trials go-to-patients be overcome.
Язык: Английский
Процитировано
1
Advances in bioinformatics and biomedical engineering book series, Год журнала: 2024, Номер unknown, С. 177 - 210
Опубликована: Апрель 19, 2024
Regenerative medicine involves the use of stem cells to repair or replace damaged tissues. Stem are undifferentiated capable differentiating into specialized types depending upon their origin. The purpose this book chapter is introduce cells, characteristic features, source and culturing cryopreservation procedures. important breakthrough in field was Induced pluripotent (IPSCs) directed differentiation. IPSCs made it possible patient's for regenerative altogether preventing transplantation rejections. have many applications healthcare including tissue regeneration, generate disease models, drug testing discovery gene editing. Here chapter, authors discussed cell therapy treating Leukemia, autoimmune, eye diseases, skin disorders, neurodegenerative diseases diabetic foot ulcers. relevance as models becoming animals research refrained reduced.
Язык: Английский
Процитировано
0
Academia molecular biology and genomics., Год журнала: 2024, Номер 1(1)
Опубликована: Окт. 10, 2024
Язык: Английский
Процитировано
0