A Review of Wearable Electroceutical Devices for Chronic Wound Healing
Electronics,
Год журнала:
2025,
Номер
14(7), С. 1376 - 1376
Опубликована: Март 29, 2025
A
chronic
wound
is
a
that
fails
to
progress
through
the
normal
stages
of
healing
within
typical
time
frame,
often
remaining
open
and
unhealed
for
more
than
4
6
weeks.
The
delayed
associated
with
comorbidities,
its
clinical
consequences
have
posed
great
concern
patients,
caregivers,
researchers.
use
electrostimulation
enhance
in
wounds
has
received
attention
last
20
years.
Innovative
wearable
electroceutical
devices
are
engineered
while
prioritizing
patient
convenience.
These
employ
controlled
micro-electrostimulation
reactivate
endogenous
bioelectric
activities
needed
cellular
signaling.
However,
these
their
mechanisms
not
been
fully
explored.
In
this
systematic
review,
three
databases
articles
published
between
2000
2023
were
searched
screened
using
strict
inclusion
criteria
adhering
PRISMA
checklist.
We
identified
direct,
pulsed,
alternating
electric
currents
as
primary
modalities
by
deliver
electrical
stimulation
wounds.
Typical
include
diabetic
foot
ulcers,
pressure
venous
ulcers.
Additionally,
few
materials
crucial
reviewed,
recent
research
considered
study.
Various
devices,
including
triboelectric
piezo-nanogenerators,
potential
functionalities
generating
relevant
applications.
literature
lacked
closed-loop
platforms
treatment
concurrent
monitoring
healing.
analysis
taken
from
review
provides
opportunities
at
intersection
epidermal
soft
bioelectronics,
care,
remote
sensing.
Язык: Английский
The effect of blue and green light on human umbilical cord mesenchymal stem cells for promoting proliferation and wound healing
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 28, 2025
Photobiomodulation
(PBM)
has
been
widely
utilized
in
regenerative
medicine,
including
dermatology,
dentistry,
and
neurology.
However,
the
optimal
energy
density
of
PBM
for
human
umbilical
cord
mesenchymal
stem
cells
(hUC-MSCs)
remains
underexplored,
hindering
its
development
potential
clinical
application.
This
study
aims
to
identify
wavelength
irradiation
fluence
promoting
proliferation
hUC-MSCs
by
comparing
effects
different
wavelengths
fluences.
Our
results
show
that
green
light
enhances
anti-inflammatory
properties
hUC-MSCs,
with
76s
being
most
effective
inhibiting
IL-6
GM-CSF.
Blue
38
s
is
more
angiogenesis,
significantly
increasing
mRNA
protein
secretion
VEGF,
HGF,
FGF2
compared
non-irradiated
group.
The
peak
times
varied,
VEGF
peaking
at
72
h
HGF
24
h.
RNA-Seq
confirms
significant
roles
blue
epithelial-mesenchymal
transition
inflammation.
In
vitro
co-culture
models
conditioned
media
experiments
validate
these
effects.
These
findings
have
important
implications
accelerating
application
cell
therapies
provide
new
references
use
hUC-MSCs.
Язык: Английский