Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis DOI Creative Commons
Mariusz Z. Ratajczak, Adrian Konopko, Justyna Jarczak

и другие.

Leukemia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract Hematopoietic cells and lymphocytes arise from a common stem cell for both lineages. This explains why similar signaling networks regulate the development biological functions of these cells. One crucial regulatory mechanism involves interactions with soluble mediators innate immunity, including activated elements complement cascade (ComC). For many years, ComC proteins were thought to be synthesized only in liver released into blood by one three proteolytic cascades. The effects components on hematopoietic progenitor (HSPCs) mature have been well demonstrated past. However, recent data indicate that are also expressed several types, immune intracellular network has named “complosome.” Recent evidence our group shows complosome is HSPCs plays an important yet underappreciated role expansion, trafficking, metabolism We propose complosome, like its lymphocytes, necessary optimal function mitochondria cells, HSPCs. opens new area investigation potential pharmacological intervention normal malignant hematopoiesis.

Язык: Английский

Biosynthesis and yield improvement strategies of fengycin DOI
Junfeng Sun, Xiaohua Qi, Chunmei Du

и другие.

Archives of Microbiology, Год журнала: 2025, Номер 207(4)

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0
Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis DOI Creative Commons
Mariusz Z. Ratajczak, Adrian Konopko, Justyna Jarczak

и другие.

Leukemia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract Hematopoietic cells and lymphocytes arise from a common stem cell for both lineages. This explains why similar signaling networks regulate the development biological functions of these cells. One crucial regulatory mechanism involves interactions with soluble mediators innate immunity, including activated elements complement cascade (ComC). For many years, ComC proteins were thought to be synthesized only in liver released into blood by one three proteolytic cascades. The effects components on hematopoietic progenitor (HSPCs) mature have been well demonstrated past. However, recent data indicate that are also expressed several types, immune intracellular network has named “complosome.” Recent evidence our group shows complosome is HSPCs plays an important yet underappreciated role expansion, trafficking, metabolism We propose complosome, like its lymphocytes, necessary optimal function mitochondria cells, HSPCs. opens new area investigation potential pharmacological intervention normal malignant hematopoiesis.

Язык: Английский

Процитировано

0