The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109922 - 109922
Опубликована: Апрель 1, 2025
Psoriasis
is
one
of
the
most
common
chronic
inflammatory
skin
diseases.
Many
studies
suggest
that
dendritic
cells
(DCs)
and
T
cell-mediated
interleukin
(IL)-23/IL-17
axis
play
a
central
role
in
signaling
pathway
pathogenesis
psoriasis.
Chlorella,
also
known
as
Parachlorella
beijerinckii
(PB),
unicellular
green
alga
has
long
been
used
health
food.
It
contains
carotenoids
have
antioxidant
anti-inflammatory
effects.
In
this
study,
we
investigated
whether
PB-derived
(PBCs)
ameliorated
processes
an
imiquimod
(IMQ)-induced
psoriasis-like
mouse
model
bone
marrow-derived
(BMDCs).
We
found
PBCs
attenuated
erythema,
thickness,
scaling,
neutrophil
infiltration
tissue
IMQ-induced
mice.
Moreover,
suppressed
psoriasis-related
pro-inflammatory
cytokine
expression,
DC
activation,
IL-17A
production
by
γδ
BMDCs,
expression
levels
cytokines,
including
IL-23;
IL-1β;
IL-6;
CD40/CD86,
marker
activation.
Additionally,
inhibited
nuclear
factor
kappa
B,
p38,
c-Jun
NH2-terminal
kinase
pathways
mitochondrial
reactive
oxygen
species
(mitoROS)-triggered
inflammasome
activation
pathway.
activated
extracellular
regulated
protein
kinase/NF-E2-related
factor-2
(ERK/Nrf2)
BMDCs.
harmful
effects
gene
mitoROS
via
ERK/Nrf2
conclusion,
may
be
beneficial
management
psoriatic
inflammation.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 792 - 792
Опубликована: Янв. 18, 2025
Vascular
cell
adhesion
molecule-1
(VCAM-1)
and
E-selectin
are
involved
in
different
inflammatory
diseases
may
be
potential
cardiovascular
risk
biomarkers
psoriasis.
They
play
an
important
role
regulating
the
recruitment
to
endothelial
cells
during
inflammation,
affecting
various
conditions
like
vasculitis,
atherosclerosis,
diseases.
Positive
outcomes
have
been
observed
when
using
Tumor
Necrosis
Factor
Alpha
(TNF-α)
inhibitors
biological
therapies
that
target
selectins
control
functioning
of
reduce
inflammation
psoriasis
related
conditions.
Moreover,
effects
systemic
treatments
ultraviolet
B
(UVB)
phototherapy
on
VCAM-1
levels
patients
highlights
impact
severity
activation
cells.
In
addition,
factors
such
as
age,
sex,
metabolic
syndrome,
hyperglycemia,
migraines,
tobacco
smoking
found
affect
E-selectin.
This
sheds
light
understanding
complex
relationship
between
development
Studies
show
indicators
treatment
effectiveness
progression
disease.
summary,
this
review
importance
for
assessing
disease
individuals
with
The
shared
mechanisms
along
effect
markers,
provide
significant
insights
further
research
approaches
manage
future.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 25, 2024
Chronic
rhinosinusitis
(CRS)
is
a
prevalent
inflammatory
airway
disease
affecting
over
10%
of
the
global
population,
leading
to
considerable
socio-economic
impacts,
especially
in
developing
countries.
The
pathogenesis
CRS
multifactorial,
involving
potential
contributions
from
both
genetic
and
environmental
factors.
While
influence
allergic
autoimmune
diseases
on
has
been
observed,
causal
relationships
between
these
remain
unclear.
We
extracted
data
large-scale
genome-wide
association
studies
(GWAS)
utilized
bidirectional
two-sample
Mendelian
randomization
(MR)
analysis
explore
ten
diseases,
including
asthma,
rhinitis
(AR),
atopic
dermatitis
(AD),
psoriasis,
type
1
diabetes
(T1D),
hypothyroidism,
celiac
(CeD),
multiple
sclerosis
(MS),
rheumatoid
arthritis
(RA),
systemic
lupus
erythematosus
(SLE).
Additionally,
we
conducted
colocalization
determine
whether
allergic/autoimmune
showing
statistical
with
are
driven
by
same
variants.
MR
identified
that
AR
(OR
=
1.30;
95%
CI
1.21-1.40;
P
3.26E-13),
asthma
1.35;
1.25-1.45;
1.35E-14),
AD
1.17;
1.06-1.30;
0.003)
were
significantly
associated
an
increased
risk
CRS.
Interestingly,
psoriasis
0.05;
0.01-0.37;
0.004)
appeared
have
protective
effect
against
Associations
for
T1D
hypothyroidism
also
suggestive
as
factors
No
significant
associations
reverse
analysis,
suggesting
one-directional
relationship.
Colocalization
indicated
(PP.H4
0.99)
shared
variant
(IL-33
rs3939286)
In
conclusion,
our
study
confirmed
(AR,
AD,
psoriasis)
Notably,
variant,
rs3939286
IL-33
gene,
CRS,
targeting
pathway
may
provide
therapeutic
strategy
diseases.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 283 - 283
Опубликована: Фев. 20, 2025
Psoriasis
is
a
chronic
inflammatory
disease
with
complex
pathogenesis,
influenced
by
various
factors
involving
environment,
genes,
and
immunity.
The
main
symptoms
of
psoriasis
include
erythema,
scales,
itching,
etc.
At
present,
therapeutic
drugs
for
are
continually
evolving
towards
enhancing
treatment
efficacy
reducing
side
effects.
Firstly,
the
pathogenesis
characteristics
were
summarized.
Then,
types
benefits
topical
therapy
introduced,
such
as
aspects
avoiding
systemic
toxic
effects,
first
pass
effect,
gastrointestinal
reactions
accelerating
onset
time
improving
its
efficacy,
compared
to
drugs.
In
case
methotrexate,
cyclosporin
A,
Janus
kinase
(JAK)
inhibitors,
phosphodiesterase-4
(PDE-4)
this
review
had
further
discussion
on
improvement
translation
these
molecules
from
in
clinical
practice.
To
augment
limitation
skin
permeability,
nanotechnology
novel
drug
delivery
system
including
nanomedicines,
hydrogels,
ionic
liquids,
microneedles
elaborated
management.
Also,
exploration
targeting
pathogenic
genes
through
small
interfering
RNA
(siRNA)
using
nanoparticles
liquids
(ILs)
great
significance
long-term
psoriasis.
Taken
together,
development
numerous
platforms
expected
achieve
enhanced
penetration,
precise
efficient
molecule
interference
(RNAi)
therapeutics
prospects.
Experimental Dermatology,
Год журнала:
2025,
Номер
34(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Fibroblasts
(FBs)
are
crucial
mesenchymal
cells
that
preserve
the
skin's
natural
structure
and
physiological
processes.
They
can
build
dense
connective
tissue
by
remodelling
extracellular
matrix
(ECM)
control
immunological
activity
secreting
cytokines.
This
indicates
development
of
chronic
inflammatory
proliferative
skin
disorders
is
significantly
influenced
fibroblasts.
In
order
to
provide
new
ideas
for
clinical
research
treatment
with
a
clearer
perspective,
this
study
thoroughly
compiles
involvement
fibroblasts
in
various
diseases
such
as
psoriasis,
hypertrophic
scar
(HS),
keloid,
atopic
dermatitis
(AD),
oral
lichen
planus
(OLP),
eczema,
rosacea.
