Parachlorella beijerinckii-derived carotenoids ameliorate inflammation in a psoriasis-like mouse model via modulation of pro-inflammatory cytokines in dendritic cells DOI Creative Commons
Yuya Nakashima, Kazuhito Gotoh,

Mikako Yagi

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109922 - 109922

Опубликована: Апрель 1, 2025

Psoriasis is one of the most common chronic inflammatory skin diseases. Many studies suggest that dendritic cells (DCs) and T cell-mediated interleukin (IL)-23/IL-17 axis play a central role in signaling pathway pathogenesis psoriasis. Chlorella, also known as Parachlorella beijerinckii (PB), unicellular green alga has long been used health food. It contains carotenoids have antioxidant anti-inflammatory effects. In this study, we investigated whether PB-derived (PBCs) ameliorated processes an imiquimod (IMQ)-induced psoriasis-like mouse model bone marrow-derived (BMDCs). We found PBCs attenuated erythema, thickness, scaling, neutrophil infiltration tissue IMQ-induced mice. Moreover, suppressed psoriasis-related pro-inflammatory cytokine expression, DC activation, IL-17A production by γδ BMDCs, expression levels cytokines, including IL-23; IL-1β; IL-6; CD40/CD86, marker activation. Additionally, inhibited nuclear factor kappa B, p38, c-Jun NH2-terminal kinase pathways mitochondrial reactive oxygen species (mitoROS)-triggered inflammasome activation pathway. activated extracellular regulated protein kinase/NF-E2-related factor-2 (ERK/Nrf2) BMDCs. harmful effects gene mitoROS via ERK/Nrf2 conclusion, may be beneficial management psoriatic inflammation.

Язык: Английский

Integrating Transcriptomics and Network Pharmacology to Reveal the Effect and Mechanism of Bai-Jie-Jing-Xie Ointment on Improving Skin Inflammation of Psoriasis DOI
Yuping Lin,

Xiujuan Zhao,

Ziqing Yang

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119680 - 119680

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The relationship between psoriasis and gut microbiota: a review of the literature DOI

Valeria Pavlovna Vasilieva,

Daria Sergeevna Yenina,

E. Kapustina

и другие.

Russian Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Psoriasis is a systemic immuno-inflammatory disease affecting target organs and manifested mainly by defect formation on the skin due to hyperproliferation of keratinocytes. This can significantly reduce person's quality life. widespread: according literature data, it occurs in about 2% entire world population. The study pathogenesis psoriasis its effect body an actual direction dermatology. Numerous works recent years reveal certain correlation between inflammatory bowel diseases. It has been found that there decrease qualitative quantitative diversity intestinal microflora increase number opportunistic bacteria such as E.Coli, Helicobacter ssp., Mycobacterium spp. patients with psoriasis. Along this, Firmicutes Bacteroides are patients. A leads reduced butyrate, butyrate turn plays role defence system epithelium. Altered gut microbiome may be reason for stimulation autoimmune inflammation Many studies also agree severe course increases difference control groups. Gut dysbiosis stimulus recurrence. Increased permeability epithelium favours entry more bacterial metabolites into blood, which aggravates Clinical observations confirm improvement psoriatic lesions after use antibiotics, probiotics or transplantation faecal microbiota. detailed relationship serve potential marker evaluation therapy, improving life this pathology.

Язык: Английский

Процитировано

0
L-Arginine and Immune Modulation: A Pharmacological Perspective on Inflammation and Autoimmune Disorders DOI
Igbayilola Yusuff Dimeji,

Kasim Sakran Abass,

Ngabea Murtala Audu

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177615 - 177615

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Unveiling the revolutionary approach for psoriasis management: Leveraging the breakthrough capabilities of hyaluronic acid DOI

Abhipsa Priyadarshinee,

Etikala Amulya,

Ganesh Vambhurkar

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143089 - 143089

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Parachlorella beijerinckii-derived carotenoids ameliorate inflammation in a psoriasis-like mouse model via modulation of pro-inflammatory cytokines in dendritic cells DOI Creative Commons
Yuya Nakashima, Kazuhito Gotoh,

Mikako Yagi

и другие.

The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109922 - 109922

Опубликована: Апрель 1, 2025

Psoriasis is one of the most common chronic inflammatory skin diseases. Many studies suggest that dendritic cells (DCs) and T cell-mediated interleukin (IL)-23/IL-17 axis play a central role in signaling pathway pathogenesis psoriasis. Chlorella, also known as Parachlorella beijerinckii (PB), unicellular green alga has long been used health food. It contains carotenoids have antioxidant anti-inflammatory effects. In this study, we investigated whether PB-derived (PBCs) ameliorated processes an imiquimod (IMQ)-induced psoriasis-like mouse model bone marrow-derived (BMDCs). We found PBCs attenuated erythema, thickness, scaling, neutrophil infiltration tissue IMQ-induced mice. Moreover, suppressed psoriasis-related pro-inflammatory cytokine expression, DC activation, IL-17A production by γδ BMDCs, expression levels cytokines, including IL-23; IL-1β; IL-6; CD40/CD86, marker activation. Additionally, inhibited nuclear factor kappa B, p38, c-Jun NH2-terminal kinase pathways mitochondrial reactive oxygen species (mitoROS)-triggered inflammasome activation pathway. activated extracellular regulated protein kinase/NF-E2-related factor-2 (ERK/Nrf2) BMDCs. harmful effects gene mitoROS via ERK/Nrf2 conclusion, may be beneficial management psoriatic inflammation.

Язык: Английский

Процитировано

0