THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury? DOI

Alison R. Van Zandt,

Miranda D. Horn,

Tiffany A. Peterson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Despite effective combination antiretroviral therapy (cART), chronic neuroinflammation and glial dysfunction continues to be an important yet understudied issue with people living HIV (PLWH). The endocannabinoid system is increasingly recognized as a potential therapeutic target for modulating neuroimmune environments, given its role in regulating synaptic plasticity, immune responses, neuroinflammatory cascades. However, the extent which cannabinoids influence HIV-associated remains unclear. This study investigates impact of Δ9-tetrahydrocannabinol (THC) on astrocyte growth characteristics, viability, senescence-associated cytokine release following exposure Tat protein using primary mixed cultures derived from rhesus macaques. Real-time impedance-based cellular integrity assessments were conducted xCELLigence system, while morphological analyses quantification performed phase-contrast microscopy multiplex immunoassays. Treatment macaques THC protected astrocytes virus-induced senescence. Further, facilitated rapid recovery Tat-induced decline adhesion, suggesting compensatory effect. promoted process elongation complexity, indicative shift toward neuroprotective phenotype. Furthermore, significantly reduced inflammatory secretion, including TNF-α, IL-6, IL-1β, apparently dose-dependent manner. These findings suggest that may modulate PLWH by promoting astrocytic survival, suppressing enhancing neurotrophic signaling. prolonged high-dose negatively survival. results underscore complexity cannabinoid signaling CNS highlight cannabinoid-based interventions mitigate neuroinflammation.

Язык: Английский

Sustainable synthesis, process optimization, and industrial applications of oleic ethanolamide DOI Creative Commons

Ghislaine M. Ndonkeu,

Egi Agustian,

Joseph Blaise L. Dongmo

и другие.

Biomass Conversion and Biorefinery, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
The Role of Endocannabinoids in Physiological Processes and Disease Pathology: A Comprehensive Review DOI Open Access

Paulina Simankowicz,

Joanna Stępniewska

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(8), С. 2851 - 2851

Опубликована: Апрель 21, 2025

The endocannabinoid system is a complex communication involved in maintaining homeostasis various physiological processes, including metabolism, immune response, pain modulation, and neuroprotection. Endocannabinoids, mainly anandamide 2-arachidonoylglycerol, are natural ligands of the cannabinoid receptors CB1 CB2, which widely distributed throughout central nervous peripheral tissues. Their biosynthesis, degradation, interaction with other signaling pathways play crucial roles both health disease. This article provides comprehensive overview pathological endocannabinoids, discusses their potential as therapeutic targets, highlights recent advances endocannabinoid-based treatments.

Язык: Английский

Процитировано

0
THC Reverses SIV-Induced Senescence in Astrocytes: Possible Compensatory Mechanism Against HIV Associated Brain Injury? DOI

Alison R. Van Zandt,

Miranda D. Horn,

Tiffany A. Peterson

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Despite effective combination antiretroviral therapy (cART), chronic neuroinflammation and glial dysfunction continues to be an important yet understudied issue with people living HIV (PLWH). The endocannabinoid system is increasingly recognized as a potential therapeutic target for modulating neuroimmune environments, given its role in regulating synaptic plasticity, immune responses, neuroinflammatory cascades. However, the extent which cannabinoids influence HIV-associated remains unclear. This study investigates impact of Δ9-tetrahydrocannabinol (THC) on astrocyte growth characteristics, viability, senescence-associated cytokine release following exposure Tat protein using primary mixed cultures derived from rhesus macaques. Real-time impedance-based cellular integrity assessments were conducted xCELLigence system, while morphological analyses quantification performed phase-contrast microscopy multiplex immunoassays. Treatment macaques THC protected astrocytes virus-induced senescence. Further, facilitated rapid recovery Tat-induced decline adhesion, suggesting compensatory effect. promoted process elongation complexity, indicative shift toward neuroprotective phenotype. Furthermore, significantly reduced inflammatory secretion, including TNF-α, IL-6, IL-1β, apparently dose-dependent manner. These findings suggest that may modulate PLWH by promoting astrocytic survival, suppressing enhancing neurotrophic signaling. prolonged high-dose negatively survival. results underscore complexity cannabinoid signaling CNS highlight cannabinoid-based interventions mitigate neuroinflammation.

Язык: Английский

Процитировано

0