Long-term outcome of thyroid abnormalities in patients with severe Covid-19

European Thyroid Journal, Год журнала: 2023, Номер 12(2)

Опубликована: Янв. 30, 2023

Objective We have previously observed thyroid dysfunction, i.e. atypical thyroiditis (painless thyrotoxicosis associated with non-thyroidal illness syndrome), in patients severe acute respiratory syndrome coronavirus 2 disease (Covid-19). This study aimed to analyse the evolution of dysfunction over time. Methods One hundred eighty-three consecutive hospitalised for Covid-19 without known history were studied at hospital admission (baseline). Survivors offered 12-month longitudinal follow-up including assessment function, autoantibodies and ultrasound scan (US). Patients showing US focal hypoechoic areas suggestive (focal hypoechogenicity) also underwent 99m Tc or 123 I uptake scan. Results At baseline, after excluding from TSH analysis, 63 out 183 (34%) commenced on steroids before hospitalisation, 12 (10%) showed thyroiditis. Follow-up 75 normalisation function inflammatory markers no increased prevalence detectable autoantibodies. Baseline (available 65 patients) hypoechogenicity 28% patients, whom 82% had reduced Tc/ uptake. The presence was baseline low ( P = 0.034), high free-thyroxine (FT4) 0.018) interleukin-6 (IL6) 0.016). Focal persisted 6 months 87% 50% respectively, but size. After 9 months, partially recovered (+28%) still 67% patients. Conclusions Severe induces mild transient correlating severity. hypoechogenicity, FT4, IL6 TSH, does not seem be related autoimmunity may persist 1 year although decreasing Long-term consequences unlikely.

Язык: Английский

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Long-term effects of COVID-19 on the endocrine system – a pilot case-control study

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Сен. 18, 2023

Coronavirus disease 2019 (COVID-19) has permanently changed the world. Despite having been a pandemic for nearly 3 years, mid- and long-term complications of this disease, including endocrine disorders, remain unclear. Our study aimed to evaluate lasting effects COVID-19 on system 6 months after initial infection.We compared patients who underwent age- sex-matched subjects from population-based conducted before pandemic. We evaluated differences in multiple parameters related metabolism fasting glucose, insulin, lipids, body composition, thyroid stimulating hormone (TSH), free thyroxine (fT4), triiodothyronine (fT3), anti-thyroglobulin (aTG) anti-thyroid peroxidase (aTPO) antibodies, prolactin, cortisol, testosterone, estradiol.We found significantly lower levels fT3 fT4, accompanied by higher TSH aTPO survivors. Moreover, we that SARS-CoV2 infection had prolactin testosterone than controls. Interestingly, were observed only male subjects. did not detect significant composition or metabolic glycemic between cases controls, except values HOMA2-B index survivors.Our indicates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might have consequences system, suppressed function gland, sex secretion. showed 6-month follow-up, no parameters, lipid profiles, liver function, cortisol levels, estradiol levels.

Язык: Английский

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Nodular goiter and anamnesis of COVID-19: clinical and pathogenetic relationships, sonographic and cytological features

Clinical Medicine (Russian Journal), Год журнала: 2025, Номер 102(9-10), С. 714 - 722

Опубликована: Фев. 5, 2025

There is literature data on the development of destructive thyroiditis in patients with COVID-19, which may increase risk thyroid pathology post-COVID period. Special attention paid to autoimmune diseases, while impact COVID-19 nodular goiter (NG) has been studied little. The aim this study was investigate sonographic and cytological features a recent history COVID-19. Materials Methods: A total 132 who sequentially presented healthcare facility between October May 2021-2022, where they were fi rst diagnosed goiter, examined. Of these, 36 denied (control group), 96 had experienced it 2-9 months prior (main group). Results: According data, there more main group microcalcifications (17 (17.8%) vs. 2 (5.6%), p = 0.047), cystic components nodules (22 (22.9%) 0.015), hypoechoic (23 (23.9%) 4 (11.1%), 0.078). In group, signs degenerative changes thyrocytes combined macrophage clusters frequently observed, nonspecifi c but common manifestation consequences (16 (39.0%) (10.0%), 0.017). Conclusion: Nodular identified period characterized by an increased prevalence microcalcifi cations, tendency towards reduced echogenicity nodules, as well cyst formation against background tissue. do not exclude propensity for oncogenic disorders.

Язык: Английский

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Assessment of changes in menstrual pattern, menstrual volume, and sex hormones (FSH, LH, TSH, prolactin, and AMH) in women of childbearing age with COVID-19 in Semnan, Iran: a cross-sectional study

Middle East Fertility Society Journal, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 28, 2025

Abstract Introduction and objectives Women’s reproductive fertility health may be influenced by COVID-19. However, data on whether SARS-CoV-2 infection affects menstrual pattern, volume, sex hormone levels remain limited. This study aimed to investigate changes in the pattern volume of menstruation as well FSH, LH, TSH, prolactin, AMH women age following Patients methods In this cross-sectional study, we enrolled 30 healthy (aged 18–36 years) who presented with male-factor infertility. Participants were included if they non-menopausal, had negative pregnancy test results, no history significant medical illness or drug treatment. Women using contraceptive treatments undergone specific therapeutic procedures medications for infertility excluded. Additionally, vaccinated against COVID-19 All participants a confirmed diagnosis (positive PCR test). To minimize acute-phase fluctuations, re-evaluated 5- 7-month post-infection. We compared pre- post-infection from their records, used screening checklist assess (e.g., oligomenorrhea, polymenorrhea) volume. Each participant effectively served her own control. Data analyzed at 95% confidence level P < 0.05 considered significant. Results The mean (± SD) was 29.23 ± 3.45 years. Nearly one-third (33%) reported new-onset after COVID-19, including oligomenorrhea (20%) polymenorrhea (13%). No experienced amenorrhea. Post-infection showed slight increase prolactin decrease AMH; however, only TSH exhibited statistically rise. Changes not associated treatment methods, hospitalization, pulmonary involvement. By contrast, those hospitalization more frequent alterations ( = 0.041 0.006, respectively). Pulmonary involvement did significantly impact pattern. Conclusion linked increases notable shifts among age, while other hormones remained largely unchanged. Further research larger sample sizes formal control group is needed clarify these observations.

Язык: Английский

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The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study

Pathogens, Год журнала: 2024, Номер 13(2), С. 101 - 101

Опубликована: Янв. 24, 2024

The association between thyroid function and viral pneumonia has undergone extensive examination, yet the presence of a causal link remains uncertain. objective this paper was to employ Two-Sample Mendelian Randomization (MR) analysis investigate connections three diseases hormone indicators with COVID-19. We obtained summary statistics datasets from seven genome-wide studies (GWASs). primary method used for estimating relationships inverse-variance weighting (IVW). In addition, we employed weighted median, mode, MR-Egger, MR-PRESSO as supplementary analytical tools. Sensitivity analyses encompassed Cochran’s Q test, MR-Egger intercept MR-PRESSO. Our study revealed significant having genetic predisposition autoimmune disease (AITD) an increased susceptibility (odds ratio [OR]: 1.096; 95% confidence interval [CI]: 1.022–1.176). Moreover, it demonstrated heightened severity COVID-19 (OR susceptibility, hospitalization, critical illness, CIs 1.016, 1.001–1.032; 1.058, 1.003–1.116; 1.045, 1.010–1.081). However, no statistically associations were found TSH, FT4, subclinical hypo- or hyperthyroidism, risk incidence, (all p > 0.05). This establishes cause-and-effect relationship AITD development pneumonia, well

Язык: Английский

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Effects of SARS-CoV-2 infection on hypothyroidism and subclinical hypothyroidism: a meta-analysis

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Дек. 4, 2023

Background In recent years, the outbreak of COVID-19 caused by SARS-CoV-2 has been witnessed globally. However, impact infection on thyroid dysfunction and subclinical remains unclear. Therefore, this meta-analysis aimed to assess effects its relationship with severity COVID-19. Methods We systematically searched databases including PubMed, Willey Library, Embase, Web Science, CNKI, Wanfang, VIP. focused randomized controlled trials, case-control studies, cohort studies published between December 2019 August 2023, examining association hypothyroidism, a specific emphasis infection. The quality research was assessed using Newcastle-Ottawa Scale (NOS), while statistical analysis conducted meta metafor packages in R 4.2.1 software. Results For meta-analysis, total eight articles were identified based strict inclusion exclusion criteria. three (266 samples) comparing TSH levels control groups showed no difference [SMD=-0.04,95%CI(-1.22,1.15), P=0.95 ]. Additionally, two TT3 (a sample 176 cases) TT4 also group group, respectively. when evaluating COVID-19, six (565 that severe significantly lower than mild [SMD = -0.55, 95% CI (-0.96, -0.14)], FT3 -0.96, (-1.24, -0.67)]. No noticeable differences observed their TT3, FT4, levels. Conclusion may have detrimental function individuals symptoms. More is needed confirm explore relationship. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO , identifier CRD42023486042.

Язык: Английский

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Clinical and pathogenetic features of thyropathies diagnosed during the post-COVID-19 period

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 13, С. 164 - 172

Опубликована: Июль 26, 2024

Introduction . The past COVID-19 pandemic has influenced the course of many diseases including endocrine pathology. However, little is known about clinical and pathogenetic features thyroid pathology post-COVID-19 period. Aim Evaluate thyropathies diagnosed during Materials methods A cross-sectional study included 250 patients with newly diseases. 73 participants denied a history 177 suffered from it within previous 9 months. Thyroid status ultrasound examination were assessed. IgG SARS-Cov-2 levels tested in 40 COVID-19. Fine needle aspiration biopsy was performed 61 41 In main group, all samples additionally investigated by immunocytochemical analysis SARS-CoV-2 protein antibodies. Results Among higher fT4 (13.6 [12.4; 15.5] vs 12.8 [11.0; 15.3] pmol/l, p = 0.046) lower proportion euthyroidism (122 (68.9%) 59 (80.8%), 0.037) detected. group there more cytological macrophages accumulations (16 (39.0%) 2 (10.0%), 0.017), however, immu-nocytochemical did not reveal any SARS-Cov-2-positive samples. During period, approximately 60% subclinical dysfunctions experienced spontaneous normalization. There correlations between parameters characterizing structural functional state gland. Conclusion most typical feature smaller individuals euthyroidism. Mild identified period tended to develop normalization cases. tests indicate absence persistence tissue. COVID-19- associated immunopathological reactions are involved pathogenesis thyropathies.

Язык: Английский

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The prognostic utility of serum thyrotropin in hospitalized Covid-19 patients: statistical and machine learning approaches

Endocrine, Год журнала: 2022, Номер 80(1), С. 86 - 92

Опубликована: Ноя. 29, 2022

Язык: Английский

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Correlation between Thyroid Responses and Inflammatory Cytokines in Critically Ill COVID-19 Patients

Biomedicines, Год журнала: 2022, Номер 11(1), С. 26 - 26

Опубликована: Дек. 22, 2022

Mechanisms involved in thyroid dysfunction critically ill coronavirus disease 2019 (COVID-19) patients are not clear. Our objective was to correlate the response with pro- and anti-inflammatory cytokines profile COVID-19 patients. This a prospective single-center study. We studied relationship between continuous variables by using Pearson correlation simple linear regression. Multiple logistic regression analysis performed analyze factors independently associated mortality. Seventy-eight were included study at intensive care unit (ICU) admission 72 had measurement of inflammatory day 5. No significant correlations found stimulating hormone (TSH), free triiodothyronine (fT3) thyroxine (fT4) ICU admission. At 5, fT4, inversely correlated IL-10 (p = 0.035). maximum lactate < 0.001) SOFA score values 0.012). The multiple showed that there (day 5) in-hospital mortality after adjusting age severity illness. In conclusion, we weak Associations interest fT4 5 be low markers organ failure death.

Язык: Английский

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Fever and Neck Pain in an Adolescent: A Case Report

Clinical Pediatrics, Год журнала: 2023, Номер 63(4), С. 560 - 563

Опубликована: Май 30, 2023

Язык: Английский

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