Beyond Antivirals: Alternative Therapies for Long COVID DOI Creative Commons

Achilleas Livieratos,

Charalambos Gogos,

Karolina Akinosoglou

и другие.

Viruses, Год журнала: 2024, Номер 16(11), С. 1795 - 1795

Опубликована: Ноя. 19, 2024

Long COVID or Post-Acute Sequelae of SARS-CoV-2 infection (PASC) is a condition characterized by numerous lingering symptoms that persist for weeks to months following the viral illness. While treatment PASC still evolving, several therapeutic approaches beyond traditional antiviral therapies are being investigated, such as immune-modulating agents, anti-inflammatory drugs, and various supportive interventions focusing at alleviating enhancing recovery. We aimed summarize breadth available evidence, identify knowledge gaps, highlight promising non-antiviral COVID/PASC. followed framework scoping methodology mapping existing evidence from range studies, including randomized clinical trials, observational research, case series. Treatments evaluated include metformin, low-dose naltrexone (LDN), dexamethasone, statins, omega-3 fatty acids, L-arginine, emerging like intravenous immunoglobulin (IVIg) apheresis. Early findings suggest metformin has strongest particularly large phase 3 while LDN dexamethasone show potential based on studies. However, many treatments lack robust, large-scale trials. This review emphasizes need further research confirm efficacy these guide practice management.

Язык: Английский

Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors DOI Creative Commons
Luigi di Filippo, Stefano Frara,

Fabrizio Nannipieri

и другие.

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 108(10), С. e1106 - e1116

Опубликована: Апрель 13, 2023

Long COVID is an emerging syndrome affecting 50% to 70% of COVID-19 survivors that still lacks predicting factors.Due the extraskeletal effects vitamin D, we retrospectively assessed association between 25(OH) D levels and long in 6 months after hospitalization.Long was defined according NICE guidelines. Fifty 50 non-long-COVID subjects matched on a 1:1 basis were enrolled from outpatient clinic post-COVID cohort seen August November 2020. Therapies/comorbidities calcium/vitamin D/bone metabolism, and/or admission intensive care unit during hospitalization exclusion criteria. Vitamin measured at hospital discharge.We observed lower levels, evaluated follow-up, with than those without (20.1 vs 23.2 ng/mL, P = .03). Regarding affected health areas entire cohort, neurocognitive symptoms follow-up (n 7) 93) (14.6 20.6 .042). In patients presenting deficiency (<20 ng/mL), both 42), by 22) presented not 20) (12.7 15.2 .041). multiple regression analyses, only variable significantly associated our (P .008, OR 1.09, CI 1.01-1.16).COVID-19 have COVID. Our data suggest should be discharge. The role supplementation as preventive strategy sequelae tested randomized controlled trials.

Язык: Английский

Процитировано

68
A view on vitamin D: a pleiotropic factor? DOI
Andrea Giustina, Marise Lazaretti‐Castro, Adrian R. Martineau

и другие.

Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(4), С. 202 - 208

Опубликована: Янв. 22, 2024

Язык: Английский

Процитировано

16
Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review DOI Open Access

Antonella Al Refaie,

Leonardo Baldassini,

Caterina Mondillo

и другие.

Nutrients, Год журнала: 2024, Номер 16(8), С. 1144 - 1144

Опубликована: Апрель 12, 2024

Nowadays, the interest in extraskeletal effects of vitamin D is growing. In literature, its several possible actions have been confirmed. Vitamin seems to a regulatory role many different fields-inflammation, immunity, and endocrine system-and studies would demonstrate correlation between cardiovascular disease. this paper, we deepened relationship dyslipidemia by reviewing available literature. The results are not entirely clear-cut: on one hand, numerous observational suggest link higher serum levels beneficial lipid profile, while other interventional do significant effect. Understanding may represent turning point: another system.

Язык: Английский

Процитировано

10
A narrative review focusing on randomized clinical trials of vitamin D supplementation for COVID-19 disease DOI Creative Commons

Huang Limi,

Zhiwei Song, Chaosheng Lu

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.

Язык: Английский

Процитировано

1
New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases DOI
Luigi di Filippo, John P. Bilezikian, Ernesto Canalis

и другие.

Endocrine, Год журнала: 2024, Номер 85(3), С. 1007 - 1019

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

8
Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study DOI Open Access
Marlene Fabiola Escobedo-Monge, M. Pilar Bahíllo‐Curieses,

Joaquín Parodi-Román

и другие.

Nutrients, Год журнала: 2024, Номер 16(9), С. 1349 - 1349

Опубликована: Апрель 29, 2024

Chronic diseases may affect the nutritional status of children and adolescents. Calcium (Ca), phosphorus (P), vitamin D (Vit-D) are crucial nutrients for their growth development. Proper diagnosis treatment critical components personalized precision medicine. Hence, we conducted a cross-sectional comparative study to evaluate Ca, P, Vit-D levels in non-skeletal functions association with health biomarkers adolescents diverse chronic conditions. We performed anthropometric, body composition, clinical evaluation, biochemical analysis, dietary survey methods. A total 78 patients (1–19 years, 43 females, 42 children) took part this study. Overall, 24, 30, 24 participants were obese, undernourished, eutrophic, respectively. Results found that 74% 35% individuals had deficient Ca intake, Most cases normocalcemic. also 47% subjects deficiency (VDD), 37% insufficient, hypophosphatemia. Of 46% 31% VDD insufficient levels, 19% 11% hypophosphatemic, Calcium, associated anthropometric parameters, mass index, physical activity, diet, hormones, immune, liver, kidney systems. These results show coincident risk altered metabolism diseases.

Язык: Английский

Процитировано

7
Long COVID and pituitary dysfunctions: a bidirectional relationship? DOI
Luigi di Filippo,

Vincenzo Franzese,

Simona Santoro

и другие.

Pituitary, Год журнала: 2024, Номер 27(6), С. 955 - 969

Опубликована: Сен. 6, 2024

Язык: Английский

Процитировано

7
Lack of vitamin D predicts impaired long-term immune response to COVID-19 vaccination DOI Creative Commons
Luigi di Filippo, Stefano Frara,

Umberto Terenzi

и другие.

Endocrine, Год журнала: 2023, Номер 82(3), С. 536 - 541

Опубликована: Авг. 17, 2023

Abstract Purpose Low vitamin D levels were reported to negatively influence the outcome of acute COVID-19, as well be linked Long-COVID. However, few studies have investigated, so far, its effects on humoral-response anti-SARS-CoV-2 vaccination, reporting conflicting results. We aimed evaluate impact baseline 25(OH)vitamin (25(OH)D) a two-dose cycle Pfizer-BioNTech-vaccine up 9–10 months after immunization. Methods retrospectively included 119 consecutive healthcare-workers (median age 53 years) without previous history COVID-19 or immunoglobulins presence immunized with two doses Comirnaty-vaccine from January February 2021. 25(OH)D was measured at time first-immunization. Immune response evaluated at: 0 (T0), before first-dose; T1, second-dose (21 days T0); T2, T3, T4 1, 5 and 9 respectively. Results Median 25.6 ng/mL, deficiency (25(OH)D <20 ng/mL) observed in 29 subjects (24.8%). In those deficiency, we found non-significant trend towards lower antibody-titers significantly titers compared not D-deficient, also observing more pronounced negative drop peak-T2 deficiency. A positive correlation between ( p = 0.043) found. multiple linear-regression analysis, older-age resulted independent factors associated antibody titer 0.026, 0.004; respectively). Conclusion our relatively young cohort presenting low prevalence hypovitaminosis D, long-term humoral vaccination influenced by 25(OH)D. Vitamin supplementation could tested strategy optimize campaigns prevent severe COVID-19.

Язык: Английский

Процитировано

16
The Association between Serum Vitamin D Levels and Urinary Tract Infection Risk in Children: A Systematic Review and Meta-Analysis DOI Open Access

Gan Yan,

Siyi You,

Junjie Ying

и другие.

Nutrients, Год журнала: 2023, Номер 15(12), С. 2690 - 2690

Опубликована: Июнь 9, 2023

The association between serum vitamin D levels and urinary tract infection (UTI) in children is unclear. We undertook a systematic review meta-analysis to evaluate the relationships different likelihood of UTI children. Online databases, including Web Science, PubMed, Embase, Cochrane Library, were searched up 6 February 2023 for studies based on inclusion criteria. Weighted mean difference (WMD) Odds Ratios (ORs), along with their 95% confidence intervals (CI), calculated, random-effects model was used analysis. Twelve case–control one cross-sectional study (839 929 controls) included. found that had lower than healthy controls (WMD: −7.730, CI: −11.57, −3.89; p < 0.001). Low significantly associated (OR: 2.80; 1.55, 5.05; = having increased when level less 20 ng/mL 5.49, 1.12, 27.04; 0.036). Therefore, level, especially ng/mL, risk factor UTI.

Язык: Английский

Процитировано

13
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy DOI Creative Commons
Adel A. Gomaa,

Yasmin A. Abdel-Wadood,

Romany H. Thabet

и другие.

Inflammopharmacology, Год журнала: 2023, Номер 32(1), С. 249 - 271

Опубликована: Ноя. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Язык: Английский

Процитировано

13