Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH)

Nature Reviews Drug Discovery, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

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Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Апрель 2, 2024

Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude complications. Thus proper diagnostics, which includes identifying secondary causes dyslipidemia crucial. Endocrine are an important cause dyslipidemia. This paper aims to review publications on lipoprotein alterations endocrine from past two years and provide overview recent discoveries this dynamically developing large field. Significant changes serum concentrations present endocrinological diseases can be modified with treatment. Some lipoproteins have also been proposed as markers some diseases, e.g., thyroid carcinoma. From scope disorders, largest number studies explored polycystic ovary syndrome women during menopausal peri-menopausal period. Even though association already well studied, new research has delivered exciting findings about euthyroid patients either positive antithyroid peroxidase antibodies or reduced sensitivity hormones. The problem adverse metabolic profile, including hypoprolactinemia recognized. Moreover, describes other significant encompassing adrenals, thyroid, parathyroid glands, pituitary, gonads. up-to-date knowledge influence hormonal prudent it significantly impact therapeutic decisions.

Язык: Английский

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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality

Nefrología (English Edition), Год журнала: 2025, Номер 45(1), С. 87 - 93

Опубликована: Янв. 1, 2025

Chronic kidney disease (CKD) is associated with high cardiovascular (CVD) risk, and requires specific interventions to decreases CVD risk. The guidelines indicate that systematic global risk assessment recommended in individuals any major vascular factor. European Society Cardiology (ESC) guidelines, he Renal Association (ERA) Council the Spanish of Nephrology (S.E.N.) collaboration 15 Scientific Societies recommend assessing albuminuria all these populations. We have evaluated current clinical practice regarding factors (blood pressure, albuminuria, serum cholesterol, glycemia creatinine) different adult health user populations, analyzing results separately for men women, given recent evidence on gender differences recognition, monitoring, management CKD. Observational, retrospective, non-interventional single center study performed a hospital using Electronic Health Record (EHR) data. Among 707,493 healthcare users, 612,619 were adults, 332,943 (54.3%) females; 73,632 (12.0%) had DM 121,445 (19.8%) hypertension. Mean (SD) age was 68.91±21.4 years; 261,694 (36.9%) older than 50 years. Only 8522 (1.39%) undergone testing as compared 264,684 (43.21%) tested creatinine, 140,492 (22.93%) 263,381 (42.99%) glucose, 226,448 (36.96%) blood pressure. Albuminuria only factor assessed more frequently women. Albuminuria, other factors, patients (6.71% patients) or hypertension (4.81%), but remained suboptimal 58-87% factors. For adults diabetes hypertension, those years also at 2.24%, 31-47% EGFR are needed screen CKD, meaning urine test albumin creatinine needed. To these, we may add cholesterol (for familial hypercholesterolemia) glucose Diabetes. (up nearly 60% frequently), indicating screening CKD women suboptimal. This result surprisingly consistent across time groups. first disparities been revealed. infrequently, even especially

Язык: Английский

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Primary Hyperparathyroidism and Cardiovascular Disease: An Association Study Using Clinical Natural Language Processing Systems and Big Data Analytics

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(21), С. 6718 - 6718

Опубликована: Окт. 24, 2023

Primary hyperparathyroidism (PHPT) seems to be associated with different cardiovascular diseases (CVDs). We evaluated the association of PHPT major CV risk factors (CVRFs) and CVDs by using artificial intelligence (AI) tools. An observational retrospective study was conducted data from electronic health records (EHRs) Hospital Universitario Puerta de Hierro Majadahonda (Spain). Of a total 699,157 patients over 18 years age studied (54.7% females), 6515 (0.9%; 65.4% women; mean 67.6 ± 15.9 years) had diagnosis PHPT. The overall frequencies hypertension, dyslipidemia, diabetes mellitus, smoking habit in cohort PTHP were all significantly (p < 0.001) higher than those found without PTHP. frequency stroke, ischemic heart disease, atrial fibrillation, deep vein thrombosis, pulmonary embolism that A multivariate regression analysis showed independently evaluated. Our show there is significant between main CVRFs our hospital population.

Язык: Английский

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Unexpected Grave’s-induced acute myocardial infarction in a young female, a literature review based on a case report

International Journal of Emergency Medicine, Год журнала: 2024, Номер 17(1)

Опубликована: Сен. 4, 2024

Язык: Английский

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Cardiovascular risk assessment: Missing albuminuria contributing to gender inequality

Nefrología, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Chronic Kidney Disease (CKD) is associated with high cardiovascular disease (CVD) risk, and require specific interventions to decreases CVD risk.The guidelines indicate that systematic global risk assessment recommended in individuals any major vascular factor. The European Society Cardiology (ESC) guidelines, he Renal Association (ERA) Council the Spanish of Nephrology (S.E.N.) collaboration 15 Scientific Societies recommend assessing albuminuria all these populations.We have evaluated current clinical practice regarding factors (blood pressure, albuminuria, serum cholesterol, glycemia creatinine) different adult health user populations, analyzing results separately for men women, given recent evidence on gender differences recognition, monitoring, management CKD. Methods: Observational, retrospective, non-interventional single centre study performed a hospital using Electronic Health Record(EHR) data. Results: Among 707,493 healthcare users, 612,619 were adults, 332,943 (54.3%) females; 73,632 (12.0%) had DM 121,445 (19.8%) hypertension. Mean (SD) age was 68,91±21,4 years; 261,694 (36.9%) older than 50 years.Only 8,522 (1.39%) undergone testing as compared 264,684 (43.21%) tested creatinine, 140,492 (22.93%) 263,381 (42.99%) glucose, 226,448 (36.96%) blood pressure. Albuminuria only factor assessed more frequently women.Albuminuria, other factors, patients (6.71% patients) or hypertension (4.81%), but remained suboptimal 58% 87% factors. For adults diabetes hypertension, women.Albuminuria those years also at 2.24%, 31% 47% factors.Albuminuria EGFR are needed screen CKD, meaning urine test albumin creatinine needed. To these, we may add Blood Cholesterol (for familial hypercholesterolemia) glucose Diabetes. (up nearly 60% frequently), indicating screening CKD women suboptimal. This result surprisingly consistent across time groups. first disparities has been revealed. Conclusion: infrequently, even especially women.

Язык: Английский

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Molecular Study of Sudden Cardiac Death

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6366 - 6366

Опубликована: Июнь 8, 2024

The aim of the Special Issue “Molecular study sudden cardiac death” was to gather new studies on molecular biology death, from both a fundamental and clinical perspective [...]

Язык: Английский

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Integration of big data analytics in the investigation of the relationship between acromegaly and cancer

Endocrinología Diabetes y Nutrición, Год журнала: 2024, Номер 71(8), С. 324 - 331

Опубликована: Июль 9, 2024

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Integration of big data analytics in the investigation of the relationship between acromegaly and cancer

Endocrinología Diabetes y Nutrición (English ed ), Год журнала: 2024, Номер 71(8), С. 324 - 331

Опубликована: Окт. 1, 2024

Язык: Английский

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