Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto’s thyroiditis
Lupus,
Год журнала:
2024,
Номер
33(11), С. 1235 - 1241
Опубликована: Авг. 9, 2024
Objective
Increased
frequency
of
autoimmune
thyroid
disease,
particularly
Hashimoto’s
thyroiditis
(HT)
was
reported
several
studies
in
the
literature,
individuals
with
childhood-onset
systemic
lupus
erythematosus
(cSLE).
Our
study
aimed
to
investigate
prevalence
and
contributing
factors
dysfunction
HT
among
cSLE
patients.
Methods
Thyroid
function
tests
were
obtained
cross-sectionally
from
Demographic,
clinical,
laboratory
characteristics
activity
scores
collected
medical
records.
Patients
diagnosed
compared
healthy
control
group
for
dysfunction.
The
Mann-Whitney
U,
independent
samples
t
test,
Chi-square
or
Fisher’s
exact
test
used
compare
groups.
A
p-value
below
0.05
considered
statistically
significant.
Results
Out
73
patients,
14
(19.1%)
had
subclinical
hypothyroidism,
9
(12.3%)
clinical
12
(16.4%)
HT,
a
family
history
HT.
USG
performed
5
euthyroid
patients
1
borderline
hypothyroid
patient
positive
autoantibody
as
diffuse
heterogeneous
echogenicity
enlargement
gland.
There
no
significant
differences
data
medication
between
groups
without
HT;
however,
higher
hypothyroidism
Cumulative
prednisolone
dose
significantly
lower
considerably
group.
Conclusion
results
demonstrate
an
increased
incidence
even
if
they
are
euthyroid,
recommend
that
be
screened
more
frequently.
Язык: Английский
Autoimmune thyroiditis — what is new?
Clinical and experimental thyroidology,
Год журнала:
2024,
Номер
19(4), С. 4 - 12
Опубликована: Июнь 11, 2024
Recently,
the
prevalence
of
autoimmune
diseases
has
been
steadily
increasing
among
population,
posing
a
significant
problem
for
healthcare.
One
most
common
pathologies
is
thyroiditis
(AIT).
Due
to
absence
prognostic
markers
predict
outcomes
AIT,
such
as
development
hypothyroidism,
there
an
necessity
molecular-genetic
research
into
changes
occurring
within
this
disease.
This
likely
contribute
new
diagnostic
methods
and
identification
key
aspects
pathogenesis,
thereby
preventing
process.
area
includes
analyzing
impact
environmental
factors
on
Investigating
relationships
between
stages
AIT
pathogenesis
can
form
basis
aimed
at
modifying
these
prevent
disease
progression.
Studying
comorbidity
various
thyroid
different
etiologies,
helps
identify
high-risk
groups
subsequent
screening
early
detection.
Thus,
exploring
molecular-biological
lays
foundation
developing
effective
strategies
in
prevention,
diagnosis,
therapy,
improving
quality
life
patients.
Язык: Английский