Development of a Nomogram‐Based Online Calculator for Predicting Cancer‐Specific Survival in Patients With Digestive Tract Mixed Neuroendocrine‐Non‐Neuroendocrine Neoplasms (MiNENs): An Analysis of the SEER Database
Cancer Reports,
Год журнала:
2025,
Номер
8(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Aims
Mixed
neuroendocrine‐non‐neuroendocrine
neoplasms
(MiNENs)
represent
a
rare
and
heterogeneous
subgroup
of
that
typically
consist
neuroendocrine
(NE)
component,
most
commonly
carcinoma
(NEC),
alongside
non‐neuroendocrine
(non‐NE)
component.
They
occur
in
the
digestive
tract,
their
prognosis
is
influenced
by
multiple
factors.
This
article
aimed
to
identify
factors
affect
cancer‐specific
survival
(CSS)
MiNENs
develop
an
effective
nomogram‐based
online
calculator
validate
its
effectiveness.
Methods
The
clinical,
pathological,
epidemiological,
data
patients
with
tract
were
collected
from
Surveillance,
Epidemiology,
End
Results
(SEER)
database
spanning
2000
2020.
Then,
dataset
was
divided
into
training
cohort
validation
cohort.
χ
2
test
or
Fisher's
exact
utilized
assess
differences
demographic
clinicopathological
characteristics
between
two
groups.
Kaplan–Meier
curves
log‐rank
tests
employed
conduct
analysis.
Additionally,
univariate
multivariate
Cox
regression
analyses
performed
potential
prognostic
nomograms
for
predicting
CSS
at
1,
3,
5
years.
Lastly,
predictive
ability
subsequently
compared
sixth
edition
American
Joint
Committee
on
Cancer
(AJCC)
TNM
staging
system
using
Harrell
concordance
index
(C‐index),
area
under
receiver
operating
characteristic
curve
(AUC),
calibration
curve,
decision
analysis
(DCA).
A
total
330
randomly
assigned
groups,
namely,
(
n
=
231)
99).
revealed
significant
association
lower
cumulative
age
≥
65
years,
poor
tumor
grade,
lack
surgical
treatment,
stages
III
IV,
distant
metastasis.
In
cohort,
nomogram
incorporating
surgery,
stage,
metastasis
developed,
which
demonstrated
favorable
discriminatory
capabilities.
Compared
staging,
exhibited
satisfactory
performance
1‐year,
3‐year,
5‐year
rates.
C‐index
value
0.787
0.738
respectively.
achieved
AUC
85.81%,
85.86%,
87.32%
1‐year
CSS,
3‐year
contrast,
these
values
78.46%,
81.50%,
83.88%
Conclusions
developed
offers
novel
approach
MiNENs.
Indeed,
it
can
accurately
predict
over
thereby
assisting
enhancing
formulating
appropriate
treatment
strategies.
Язык: Английский
Functioning neuroendocrine tumors (NET): Minimum requirements for a NET specialist
Cancer Treatment Reviews,
Год журнала:
2025,
Номер
135, С. 102907 - 102907
Опубликована: Фев. 27, 2025
Язык: Английский
The association between non-HDL cholesterol and high-grade pancreatic neuroendocrine neoplasms
Endocrine,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 6, 2024
Язык: Английский
Investigating the causal relationship between gut microbiota and gastroenteropancreatic neuroendocrine neoplasms: a bidirectional Mendelian randomization study
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 13, 2024
Background
The
interaction
between
the
intestinal
flora
and
gastroenteropancreatic
neuroendocrine
neoplasms
(GEP-NENs)
remains
poorly
understood,
despite
known
effect
of
gut
microbiota
on
gastrointestinal
adenocarcinomas.
Hence,
present
research
aimed
to
determine
potential
causal
correlation
GEP-NENs
by
conducting
a
bidirectional
Mendelian
randomization
(MR)
analysis.
Methods
Two-sample
MR
analysis
was
conducted
using
summary
statistics
from
MiBioGen
consortium
those
FinnGen
project.
inverse-variance
weighted
approach
utilized
as
primary
analytical
method.
To
enhance
robustness
our
findings,
multiple
sensitivity
tests
were
performed,
including
Cochran’s
Q
test
for
evaluating
heterogeneity,
MR-Egger
intercept
detect
horizontal
pleiotropy,
MR-PRESSO
identify
outliers
assess
pleiotropy
bias.
Additionally,
leave-one-out
performed
validate
consistency
findings.
MR-Steiger
also
direction
in
GEP-NENs.
Finally,
reverse
causality
Results
We
identified
42
taxa
that
potentially
causally
associated
with
GEP-NENs;
these
taxa,
7,
8,
11,
16
pancreatic
NENs,
colorectal
small
gastric
respectively.
After
adjusting
false
discovery
rate
(FDR)
correction,
we
found
significant
links
Euryarchaeota
NENs
Family
XIII
UCG-001
NENs.
analyses
confirmed
stability
correlations.
In
analysis,
be
variations
8
6
different
microbiota,
FDR
no
detected
flora.
Conclusion
study
reveals
association
certain
GEP-NENs,
thus
providing
new
perspectives
regarding
role
development
tumors.
These
insights
could
provide
innovative
approaches
screen
prevent
diseases.
Язык: Английский
Neuroendocrine tumors and survival rates in MEN-1 patients: impact of gender difference
Neuroendocrinology,
Год журнала:
2024,
Номер
unknown, С. 1 - 7
Опубликована: Окт. 28, 2024
Introduction:
Multiple
endocrine
neoplasia
type
1
(MEN-1)
is
the
most
common
inherited
syndrome
associated
with
NET
development
and
gender-specific
differences
are
emerging
in
neuroendocrine
tumors
(NETs).
This
study
aimed
to
analyze
gender
difference
a
single
cohort
of
MEN-1
patients
focusing
on
duodeno-pancreatic
(DP)-NET
survival
rates.
Methods:
referred
Endocrinology
Unit
“Federico
II”
University
Naples,
ENETS
CoE,
were
retrospectively
evaluated.
Results:
Among
100
enrolled,
59
(59%)
female
41
(41%)
male,
mean
age
at
diagnosis
was
39.4
years
(range
5–86).
No
statistically
significant
association
identified
between
clinical
manifestations
(primary
hyperparathyroidism
[PHPT]
p:
1.0,
DP-NET
0.83,
pituitary
adenoma
[PA]
0.84,
lung
0.64,
thymic
0.10),
similarly,
its
individual
similar
genders.
Survival
analysis
revealed
no
genders
regarding
progression
disease
1.0
death
1.0.
Mean
progression-free
(PFS)
98.6
months
3–288),
overall
(OS)
130.1
3–444
months),
without
(PFS
0.67
OS
0.60).
The
Kaplan-Meier
curves
for
PFS
showed
0.92;
0.87).
Conclusion:
In
this
cohort,
occurrence
PHPT,
PA,
DP-NET,
NET,
nor
outcomes
including
within
subcohort,
emerged.
Therefore,
supports
screening
follow-up
both
male
patients.
Язык: Английский
Impact of dyslipidemia and lipid‐lowering therapy with statins in patients with neuroendocrine tumors
Journal of Neuroendocrinology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Abstract
Dyslipidemia
is
a
potential
unfavorable
prognostic
factor
in
neuroendocrine
tumors
(NETs);
conversely,
statins
proved
to
have
antiproliferative
effects
NET
cell
lines
and
could
be
helpful
therapeutic
strategy
for
these
patients.
The
main
objective
of
this
observational
cohort
retrospective
study
explore
the
associations
between
dyslipidemia
progression
evaluate
influence
context.
393
patients
with
histologically
confirmed
gastroenteropancreatic
or
bronchopulmonary
NETs
from
six
Italian
centres
didicated
diagnosis
therapy
were
included.
included
123
dyslipidemia,
81
which
taking
statins.
Clinicopathological
data,
including
patient
demographics,
tumor
characteristics,
treatment
details
as
well
prevalence,
timing
hypolipemic
collected.
outcome
measure
used
progression‐free
survival
(PFS).
Among
patients,
(31.3%)
had
dyslipidemia.
Statins
by
(65.8%)
dyslipidemic
mostly
atorvastatin.
Median
PFS
was
87
months
overall,
124
non‐dyslipidemic
72
(
p
=
.268).
Dyslipidemic
on
significantly
better
median
(108
months)
than
those
not
(26
months;
.024).
Recurrence‐free
(RFS)
also
evaluated,
but
no
significant
differences
found.
In
conclusion,
while
lower
compared
difference
statistically
significant.
Statin
associated
improved
among
suggesting
effect
NETs.
These
findings
warrant
further
investigation
substantiate
role
management
Язык: Английский