Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles DOI Creative Commons
Joanna E. Moodie, Colin R. Buchanan, Anna E. Fürtjes

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms morphometry, are most strongly related individual differences domain-general cognitive functioning (g)? and 2) what underlying neurobiological properties those regions? We meta-analyse vertex-wise g-cortical morphometry (volume, surface area, thickness, curvature sulcal depth) associations using data from 3 cohorts: UK Biobank (UKB), Generation Scotland (GenScot), Lothian Birth Cohort 1936 (LBC1936), with meta-analytic N = 38,379 (age range 44 84 years old). These g-morphometry vary magnitude direction across cortex (|β| -0.12 0.17 measures) show good cross-cohort agreement (mean spatial correlation r 0.57, SD 0.18). Then, address (2), bring together existing - derive new cortical maps 33 characteristics multiple modalities (including neurotransmitter receptor densities, gene expression, functional connectivity, metabolism, cytoarchitectural similarity). discover that these profiles spatially covary along four major dimensions organisation (accounting for 65.9% variance) denote aspects scaffolding underpin patterning MRI-cognitive observe (significant |r| 0.21 0.56). Alongside analyses, make openly accessible, provide a compendium cortex-wide within-region correlations among general specific facets brain higher order functioning, hope will serve as framework analysing other behaviour-brain MRI associations.

Язык: Английский

Connectome reorganization associated with temporal lobe pathology and its surgical resection DOI Creative Commons
Sara Larivière, Bo‐yong Park, Jessica Royer

и другие.

Brain, Год журнала: 2024, Номер 147(7), С. 2483 - 2495

Опубликована: Май 3, 2024

Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical resection brain's structural connectome, explored reorganization relates clinical variables at individual patient level. We included adults with TLE (n = 37) who underwent anterior lobectomy between two imaging time points, as well age- sex-matched healthy controls comparable 31). Core analysis was projection high-dimensional connectome data-derived from diffusion MRI tractography each subject-into lower-dimensional gradients. then compared gradients patients relative before surgery, tracked surgically-induced reconfiguration pre- postoperative examined associations patient-specific phenotypes. Before individuals presented marked changes bilateral temporo-parietal regions, reflecting an increased segregation ipsilateral rest Surgery-induced localized subnetwork, but primarily involved integration contralateral regions Using partial least-squares analysis, uncovered latent signature underlying reorganization, showing that displayed fronto-occipital cortices also had greater preoperative hippocampal atrophy, lower seizure frequency secondarily generalized seizures. Our results bridge their resections large-scale interindividual variability, thus offering new avenues examine fundamental malleability

Язык: Английский

Процитировано

5
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

Опубликована: Фев. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

Процитировано

0
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Open Access
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

Опубликована: Фев. 3, 2025

The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

Процитировано

0
Multimodal gradients of basal forebrain connectivity across the neocortex DOI Creative Commons
Sudesna Chakraborty, Roy A.M. Haast, Kate M. Onuska

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Май 26, 2023

The cholinergic innervation of the cortex originates almost entirely from populations neurons in basal forebrain (BF). Structurally, ascending BF projections are highly branched, with individual cells targeting multiple different cortical regions. However, it is not known whether structural organization reflects their functional integration cortex. We therefore used high-resolution 7T diffusion and resting state MRI humans to examine multimodal gradients connectivity Moving anteromedial posterolateral BF, we observed reduced tethering between gradients, most pronounced dissimilarity localized nucleus basalis Meynert (NbM). expression this structure-function gradient revealed progressively weaker moving unimodal transmodal cortex, lowest midcingulo-insular human [ 18 F] fluoroethoxy-benzovesamicol (FEOBV) PET demonstrate that areas higher concentrations tend exhibit lower connectivity, suggesting a pattern increasingly diffuse axonal arborization. Anterograde viral tracing FEOBV mice confirmed arborization across neurons. Like humans, highest project cingulo-insular mouse isocortex. Altogether, our findings reveal vary branch complexity, certain subpopulations exhibiting greater modularity others diffusivity targets.

Язык: Английский

Процитировано

4
Multimodal Precision Neuroimaging of the Individual Human Brain at Ultra-high fields DOI Creative Commons
Donna Gift Cabalo, Ilana R. Leppert,

Risa Thevakumaran

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Multimodal neuroimaging allows for non-invasive examination of human brain structure and function across multiple scales. Precision builds upon this foundation, enabling the mapping structure, function, connectivity patterns with high fidelity in single individuals. Ultra-high field (UHF) neuroimaging, operating at magnetic strengths 7 Tesla or higher, increases signal-to-noise ratio offers even higher spatial resolution. Here, we provide a multimodal Neuroimaging Connectomics (PNI) dataset, utilizing UHF 7T resonance imaging (MRI). Ten healthy individuals underwent comprehensive MRI protocol, including T1 relaxometry, magnetization transfer imaging, T2*-weighted diffusion MRI, multi-state functional paradigms, aggregated three sessions. Alongside anonymized raw data, release cortex-wide connectomes from different modalities parcellation scales, supply gradients that compactly characterize patterning cortical organization. Our precision dataset will advance our understanding structure-function relationships individual is publicly available via Open Science Framework (https://osf.io/mhq3f/) Canadian Neuroscience Platform data portal (https://portal.conp.ca).

Язык: Английский

Процитировано

1
Exploring sex-specific neuroendocrine influences on the sensorimotor-association axis in single individuals DOI Creative Commons

Bianca Serio,

Deniz Yılmaz, Laura Pritschet

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 5, 2024

Human neuroimaging studies consistently show multimodal patterns of variability along a key principle macroscale cortical organization - the sensorimotor-association (S-A) axis. However, little is known about day-to-day fluctuations in functional activity this axis within an individual, including sex-specific neuroendocrine factors contributing to such transient changes. We leveraged data from two densely sampled healthy young adults, one female and male, investigate intra-individual daily S-A axis, which we computed as our measure by reducing dimensionality connectivity matrices. Daily was greatest temporal limbic ventral prefrontal regions both participants, more strongly pronounced male subject. Next, probed local- system-level effects steroid hormones self-reported perceived stress on organization. Our findings revealed modest that differed between hinting at subtle -potentially sex-specific- associations In sum, study points possible modulators brain organization, highlighting need for further research larger samples.

Язык: Английский

Процитировано

0
Mapping the topographic organization of the human zona incerta using diffusion MRI DOI Creative Commons
Roy A.M. Haast, Jason Kai, Alaa Taha

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Abstract The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports role ZI and surrounding regions across diverse range functions candidate target for neuromodulatory therapies. Using in vivo diffusion MRI data-driven connectivity, we identify topographic organization between neocortex. Specifically, our methods rostral-caudal gradient predominantly connecting frontopolar ventral prefrontal cortices with rostral ZI, primary sensorimotor caudal ZI. Moreover, demonstrate how clustering approaches build complementary including facilitating mapping central connected dorsal cortex. These results were shown to replicable multiple datasets at individual subject level, building important mediating frontal lobe-associated tasks, ranging from motor cognitive emotional control. Finally, consider impact on refinement targets. pave way increasingly detailed understanding substructures, considerations targeting neuromodulation.

Язык: Английский

Процитировано

0
Multimodal gradients of basal forebrain connectivity across the neocortex DOI Creative Commons
Sudesna Chakraborty, Roy A.M. Haast, Kate M. Onuska

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 18, 2024

Cortical cholinergic projections originate from subregions of the basal forebrain (BF). To examine its organization in humans, we computed multimodal gradients BF connectivity by combining 7 T diffusion and resting state functional MRI. Moving anteromedial to posterolateral BF, observe reduced tethering between structural gradients, with lowest nucleus basalis Meynert. In neocortex, this gradient is expressed progressively unimodal sensory transmodal cortex, midcingulo-insular network, also spatially correlated molecular concentration VAChT, measured [

Язык: Английский

Процитировано

0
covSTATIS: A multi-table technique for network neuroscience DOI Creative Commons
Giulia Baracchini, Ju‐Chi Yu, Jenny Rieck

и другие.

Aperture Neuro, Год журнала: 2024, Номер 4

Опубликована: Ноя. 5, 2024

Similarity analyses between multiple correlation or covariance tables constitute the cornerstone of network neuroscience. Here, we introduce covSTATIS, a versatile, linear, unsupervised multi-table method designed to identify structured patterns in data, and allow for simultaneous extraction interpretation both individual group-level features. With similarity can now be easily integrated, without requiring priori data simplification, complex black-box implementations, user-dependent specifications, supervised frameworks. Applications tutorial with Open Data source code are provided. CovSTATIS offers promising avenue advancing theoretical analytic landscape

Язык: Английский

Процитировано

0
Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles DOI Creative Commons
Joanna E. Moodie, Colin R. Buchanan, Anna E. Fürtjes

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms morphometry, are most strongly related individual differences domain-general cognitive functioning (g)? and 2) what underlying neurobiological properties those regions? We meta-analyse vertex-wise g-cortical morphometry (volume, surface area, thickness, curvature sulcal depth) associations using data from 3 cohorts: UK Biobank (UKB), Generation Scotland (GenScot), Lothian Birth Cohort 1936 (LBC1936), with meta-analytic N = 38,379 (age range 44 84 years old). These g-morphometry vary magnitude direction across cortex (|β| -0.12 0.17 measures) show good cross-cohort agreement (mean spatial correlation r 0.57, SD 0.18). Then, address (2), bring together existing - derive new cortical maps 33 characteristics multiple modalities (including neurotransmitter receptor densities, gene expression, functional connectivity, metabolism, cytoarchitectural similarity). discover that these profiles spatially covary along four major dimensions organisation (accounting for 65.9% variance) denote aspects scaffolding underpin patterning MRI-cognitive observe (significant |r| 0.21 0.56). Alongside analyses, make openly accessible, provide a compendium cortex-wide within-region correlations among general specific facets brain higher order functioning, hope will serve as framework analysing other behaviour-brain MRI associations.

Язык: Английский

Процитировано

0