Cancers, Год журнала: 2025, Номер 17(5), С. 794 - 794
Опубликована: Фев. 26, 2025
In thyroid cancer, the tumor immune microenvironment (TIME) plays a crucial role in cancer development, progression and response to treatment. Like many other cancers, creates complex network of interactions with cells directly (cell-to-cell) via humoral mediators (i.e., cytokines). This dynamic undergoes constant modification, which can lead changes immunophenotype that might explain progression, dedifferentiation resistance According immunoediting hypothesis, cancerous tumors shape their create an immunosuppressive milieu allows them evade classic surveillance. One mechanism by this occurs is through reprogramming cells, often shifting phenotypes from cytotoxic regulatory. Recent research has shed light on cellular components molecular within TIME. Immune such as Tumor-Associated Lymphocytes (TALs), myeloid-derived suppressor (MDSCs), Macrophages (TAMs) Double-Negative (DN) T seem play key roles shaping cancer. Additionally, cytokines, chemokines signaling molecules contribute communication regulation microenvironment. By studying these interactions, researchers aim uncover not just potential therapeutic targets but also biomarkers could provide clues severity progression. Based knowledge, strategies use checkpoint inhibitors, antigen-specific targeted immunotherapies, immunomodulatory agents are being explored enhance anti-tumor overcome mechanisms. review, we analyze available literature our own experience unravel complexity Continued area holds promise for improving outcomes identification markers severity/progression development innovative immunotherapeutic approaches.
Язык: Английский