Clinical Value of 18F-(2S,4R)-4-Fluoroglutamine PET/CT in Glioma DOI

Xiaoxia Xu,

Heqian Zhao, Futao Liu

и другие.

Clinical Nuclear Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Propose The aim of this study was to evaluate the clinical application value 18 F-FGln PET/CT in glioma. Patients and Methods with suspected gliomas by MRI were included study. Static and/or dynamic brain performed. PET parameters SUV max , mean MTV, TLG evaluated. Results Twenty-three patients analysis. Nineteen 23 positive for PET. high- low-grade 4.75 ± 2.21 1.00 0.66 ( P < 0.001), respectively. FGln-PET all showed statistically significant correlations glioma grade, correlation coefficients r ) 0.667 0.693 0.487 = 0.021), Additionally, exhibited higher distinguishing performance grade receiver operating characteristic curve areas under 0.976 (95% confidence interval [CI], 0.918–1) 0.002), CI, 0.835 0.628–1.000) 0.026), For isocitrate dehydrogenase (IDH) mutation status, IDH wildtype mutant 2.95 1.99 6.13 2.16 0.005), had good-to-satisfactory status area 0.885 0.734–1.000) 0.009) 0.942 0.828–1) 0.002). Conclusions Although we do not assert that imaging is satisfactory differential diagnosis glioma, revealed its potential identifying stage propose glutamine-based enables assessment metabolic nutrient uptake assist treatment patients.

Язык: Английский

Clinical Value of 18F-(2S,4R)-4-Fluoroglutamine PET/CT in Glioma DOI

Xiaoxia Xu,

Heqian Zhao, Futao Liu

и другие.

Clinical Nuclear Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Propose The aim of this study was to evaluate the clinical application value 18 F-FGln PET/CT in glioma. Patients and Methods with suspected gliomas by MRI were included study. Static and/or dynamic brain performed. PET parameters SUV max , mean MTV, TLG evaluated. Results Twenty-three patients analysis. Nineteen 23 positive for PET. high- low-grade 4.75 ± 2.21 1.00 0.66 ( P < 0.001), respectively. FGln-PET all showed statistically significant correlations glioma grade, correlation coefficients r ) 0.667 0.693 0.487 = 0.021), Additionally, exhibited higher distinguishing performance grade receiver operating characteristic curve areas under 0.976 (95% confidence interval [CI], 0.918–1) 0.002), CI, 0.835 0.628–1.000) 0.026), For isocitrate dehydrogenase (IDH) mutation status, IDH wildtype mutant 2.95 1.99 6.13 2.16 0.005), had good-to-satisfactory status area 0.885 0.734–1.000) 0.009) 0.942 0.828–1) 0.002). Conclusions Although we do not assert that imaging is satisfactory differential diagnosis glioma, revealed its potential identifying stage propose glutamine-based enables assessment metabolic nutrient uptake assist treatment patients.

Язык: Английский

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