The ZuoJinWan formula inhibits glycolysis of cisplatin resistant gastric cancer cells via p53 acetylation DOI Creative Commons
Zan Li,

Qiuxue Wu,

Zhenzhen Wei

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100347 - 100347

Опубликована: Янв. 2, 2024

Gastric cancer is one of the common malignancies worldwide, and drug resistance a major factor contributing to difficulty treatment in gastric cancer. Zuojinwan (ZJW) has been found exhibit certain inhibitory effect on tumor cells. However, molecular mechanisms ZJW reversing are still unclear. Human cisplatin-resistant cells SGC-7901/DDP BGC-823/DDP were divided into control groups, DDP groups (10 μg/mL), 2-DG (5 mM) (50 μg/mL) combined with groups. After 48 hours culture, cell proliferation inhibition rate, glucose uptake ATP, lactate production detected. Following lentiviral transfection overexpress GLUT1 HDAC1, western blot analysis was employed examine expression P53, Ace-p53, metabolism-related proteins such as GLUT1, LDHA, HK II The combination significantly inhibits glycolysis cisplatin resistant Compared group, exhibited higher rate (P< 0.01), accompanied by reduction HDAC1 P53 proteins. can enhance cells, attenuate glycolysis, reduce chemotherapy resistance. Its mechanism may be associated HDAC1/P53 axis activity.

Язык: Английский

Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors DOI
Ezgi Man, Serap Evran

Current Genomics, Год журнала: 2023, Номер 24(3), С. 136 - 145

Опубликована: Май 1, 2023

Epigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes epigenetic alterations: post-translational modifications histone proteins, control by non-coding RNA DNA methylation. Since can directly affect chromatin structure accessibility, they regulate gene expression levels. Abnormal activity deacetylases (HDACs) have been reported immune mediated diseases. Increased acetylated levels lysine residues suggested to be related overexpression inflammatory genes. This review focuses on effect HDAC non-histone proteins Furthermore, we discuss potential therapeutic inhibitors (HDACi) used these

Язык: Английский

Процитировано

3
From HDAC to Voltage-Gated Ion Channels: What’s Next? The Long Road of Antiepileptic Drugs Repositioning in Cancer DOI Open Access
Michele Pellegrino, Elena Ricci,

Rosangela Ceraldi

и другие.

Cancers, Год журнала: 2022, Номер 14(18), С. 4401 - 4401

Опубликована: Сен. 10, 2022

Cancer is a major health burden worldwide. Although the plethora of molecular targets identified in last decades and deriving developed treatments, which significantly improved patients' outcome, occurrence resistance to therapies remains cause relapse mortality. Thus, efforts identifying new markers be exploited as cancer therapy are needed. This review will first give glance on diagnostic therapeutic significance histone deacetylase (HDAC) voltage gated ion channels (VGICs) cancer. Nevertheless, HDAC VGICs have also been reported through antiepileptic drugs (AEDs) seem exert their anticancer activity. should claimed great advantage. Indeed, due slowness drug approval procedures, attempt turn off-label use already approved medicines would highly preferable. Therefore, an updated accurate overview both preclinical clinical data commonly prescribed AEDs (mainly valproic acid, lamotrigine, carbamazepine, phenytoin gabapentin) breast, prostate, brain other cancers follow. Finally, at emerging administer by means opportunely designed delivery systems (DDSs), so limit toxicity improve bioavailability, given.

Язык: Английский

Процитировано

4
β-hydroxybutyrate impairs nasopharyngeal carcinoma cell aggressiveness via histone deacetylase 4 inhibition DOI
Jinqiao Huang, Xian Chen, Lin Hong

и другие.

Molecular & Cellular Toxicology, Год журнала: 2023, Номер 20(3), С. 629 - 640

Опубликована: Июль 24, 2023

Язык: Английский

Процитировано

1
HDAC1 suppresses radiotherapy sensitivity in cervical cancer via regulating HIF-1α/VEGF signaling pathway DOI Creative Commons
Liu L, Ke Gu, Dong Hua

и другие.

Cellular and Molecular Biology, Год журнала: 2023, Номер 69(11), С. 132 - 140

Опубликована: Ноя. 15, 2023

Язык: Английский

Процитировано

1
The ZuoJinWan formula inhibits glycolysis of cisplatin resistant gastric cancer cells via p53 acetylation DOI Creative Commons
Zan Li,

Qiuxue Wu,

Zhenzhen Wei

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100347 - 100347

Опубликована: Янв. 2, 2024

Gastric cancer is one of the common malignancies worldwide, and drug resistance a major factor contributing to difficulty treatment in gastric cancer. Zuojinwan (ZJW) has been found exhibit certain inhibitory effect on tumor cells. However, molecular mechanisms ZJW reversing are still unclear. Human cisplatin-resistant cells SGC-7901/DDP BGC-823/DDP were divided into control groups, DDP groups (10 μg/mL), 2-DG (5 mM) (50 μg/mL) combined with groups. After 48 hours culture, cell proliferation inhibition rate, glucose uptake ATP, lactate production detected. Following lentiviral transfection overexpress GLUT1 HDAC1, western blot analysis was employed examine expression P53, Ace-p53, metabolism-related proteins such as GLUT1, LDHA, HK II The combination significantly inhibits glycolysis cisplatin resistant Compared group, exhibited higher rate (P< 0.01), accompanied by reduction HDAC1 P53 proteins. can enhance cells, attenuate glycolysis, reduce chemotherapy resistance. Its mechanism may be associated HDAC1/P53 axis activity.

Язык: Английский

Процитировано

0